TWiV #85 - Hepatitis C virus with Professor Michael Gale

TWiV #85 - Hepatitis C virus with Professor Michael Gale

On episode #85 of the podcast This Week in Virology, Vincent and Michael Gale discuss the origin, pathogenesis, prevention, of hepatitis C virus, and how it evades innate immune responses.

Host links Vincent Racaniello and Michael Gale

Links for this episode:
  • The Gale Laboratory at the University of Washington
  • Incredible view from the Gale laboratory (jpg)
  • Evasion and disruption of innate immune signalling by hepatitis C and West Nile viruses (review)
  • New potent HCV inhibitor
  • HCV virion and genome structures at ViralZone

Episoder(1346)

TWiV 878: Shape matters sometimes

TWiV 878: Shape matters sometimes

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TWiV 877: COVID-19 clinical update #106 with Dr. Daniel Griffin

TWiV 877: COVID-19 clinical update #106 with Dr. Daniel Griffin

In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, ...

19 Mar 202228min

TWiV 876: Spillover market with Michael Worobey

TWiV 876: Spillover market with Michael Worobey

Michael Worobey joins TWiV to explain evidence that SARS-CoV-2 emerged via the wildlife trade and that the Huanan market was the unambiguous epicenter of the COVID-19 pandemic. Hosts: Vincent Racaniel...

17 Mar 20221h 36min

TWiV 875: Animal house

TWiV 875: Animal house

TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait. Hosts: Vincent Racaniello, Dickson Despommier, and Amy R...

13 Mar 20221h 32min

TWiV 874: COVID-19 clinical update #105 with Dr. Daniel Griffin

TWiV 874: COVID-19 clinical update #105 with Dr. Daniel Griffin

In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, host fa...

12 Mar 202240min

TWiV 873: Pig viruses and big viruses

TWiV 873: Pig viruses and big viruses

TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid. Hosts: Vincent Racani...

6 Mar 20221h 56min

TWiV 872: COVID-19 clinical update #104 with Dr. Daniel Griffin

TWiV 872: COVID-19 clinical update #104 with Dr. Daniel Griffin

In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for preven...

5 Mar 202256min

TWiV 871: If the ACE2 fits, ferret

TWiV 871: If the ACE2 fits, ferret

TWiV discusses whether or not Omicron should be designated a new serotype of SARS-CoV-2, and the finding that amino acid changes that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the ...

27 Feb 20221h 42min

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