Nov 07, 2025 This Week in Cardiology

Nov 07, 2025 This Week in Cardiology

Listener feedback on non-culprit PCI in STEMI, a major cardiac result in patients on hemodialysis, news on GLP-1 agonists, a dubious stroke trial, and an AHA preview are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Listener Feedback

  • Meta-analysis of MI as a surrogate https://pubmed.ncbi.nlm.nih.gov/34694318/
  • Compare Acute Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1701067
  • DANAMI-3–PRIMULTI 10.1016/S0140-6736(15)60648-1 External Link
  • CULPRIT-SHOCK https://www.nejm.org/doi/full/10.1056/NEJMoa1710261

II Huge Cardiac News for Patients with ESRD PISCES article EMBARGOED Till 1130 AM EST

  • PISCES Trial www.nejm.org/doi/full/10.1056/NEJMoa2513032
  • REDUCE-IT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1812792
  • STRENGTH Trial https://jamanetwork.com/journals/jama/fullarticle/2773120
  • FISH trial https://jamanetwork.com/journals/jama/fullarticle/1150094

III Obesity Agents

  • White House announces deal with Lilly and Novo on GLP-1 drugs https://www.reuters.com/business/healthcare-pharmaceuticals/novo-lilly-shares-rise-trump-obesity-drug-deal-nears-2025-11-06/

Amylin Agonists

  • Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial

https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf

  • Eloralintide Phase 2 Study https://doi.org/10.1016/S0140-6736(25)02155-5

GLP-1 Comparisons

  • SURMOUNT-5 Trial https://www.nejm.org/doi/10.1056/NEJMoa2416394
  • Tirzepatide vs Semaglutide in 10-year CVD Risk Reduction https://doi.org/10.1093/ehjopen/oeaf117

IV A Problematic Trial in Stroke Care

  • LAMP trial https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2840370

V AHA Preview

AHA 2025: Mandrola's Four Trials to Look For https://www.medscape.com/viewarticle/aha-2025-mandrolas-four-trials-look-2025a1000u80

You may also like:

The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

Episoder(402)

Jun 8, 2018 This Week in Cardiology

Jun 8, 2018 This Week in Cardiology

Better equations for CV risk prediction, a drug for bradycardia, illicit drugs and MI in the young, EHR woes, and vitamins for CV risk reduction are discussed in this week's podcast.

8 Jun 201813min

Jun 01, 2018 This Week in Cardiology

Jun 01, 2018 This Week in Cardiology

Surgical left atrial appendage occlusion, renal denervation, a substudy of ORBITA, FFR and hypertension guidelines are discussed in this week's podcast.

1 Jun 201817min

May 18, 2018 This Week in Cardiology

May 18, 2018 This Week in Cardiology

Device-related thrombosis with Watchman left atrial appendage closure, debulking atrial fibrillation after ablation, rivaroxaban for stroke prevention, alteplase, and Lp(a) are discussed this week.

18 Mai 201816min

May 11, 2018 This Week in Cardiology

May 11, 2018 This Week in Cardiology

The CABANA trial on catheter ablation in patients with atrial fibrillation is discussed in this week's podcast recorded at the Heart Rhythm Scientific Sessions.

11 Mai 20189min

May 4, 2018 This Week in Cardiology

May 4, 2018 This Week in Cardiology

AHA rescinds sections of the stroke guidelines, thrombectomy for pulmonary embolism, Mitra-clip, nuts and AF, and blood pressure measurements are discussed in this week's podcast.

4 Mai 201813min

Apr 27, 2018 This Week in Cardiology

Apr 27, 2018 This Week in Cardiology

Lipid-lowering and baseline LDL-C, the CV safety of NSAIDs, 'metabolically healthy' obesity, PCI for chronic total occlusions, and wearable tech are discussed in this week's podcast.

27 Apr 201811min

Apr 20, 2018 This Week in Cardiology

Apr 20, 2018 This Week in Cardiology

Ambulatory BP measurements, advanced practice providers, medical marijuana for sleep apnea, Barbara Bush's comfort care, and apixaban for cardioversion are the topics discussed in this week's podcast.

20 Apr 20189min

Apr 13, 2018 This Week in Cardiology

Apr 13, 2018 This Week in Cardiology

Atrial fibrillation after cardiac surgery, long QT syndrome, exercise for CV prevention, a new risk factor for mothers, and coronary obstruction post TAVR are discussed in this week's podcast.

13 Apr 201811min

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