#140: How Real-World Evidence Is Shaping the Future of Multiple Sclerosis Treatment – Highlights from ECTRIMS 2025

#140: How Real-World Evidence Is Shaping the Future of Multiple Sclerosis Treatment – Highlights from ECTRIMS 2025

In this episode, I take you behind the scenes of ECTRIMS 2025 and explore seven fascinating studies that show how multiple sclerosis (MS) care is evolving — from safety monitoring and infection risks to data-driven, personalized treatment decisions.

You'll learn about:

  • How often late-onset neutropenia occurs in people on Rituximab and who's most at risk.

  • What factors increase the chance of serious infections with Ocrelizumab.

  • Why early high-efficacy treatment leads to better long-term outcomes across four countries.

  • What happens to memory B cells during long-term Ocrelizumab therapy and what that means for extended dosing intervals.

  • What the FAERS database tells us about tumor signals and why HPV vaccination remains essential for women with MS.

  • How real-world data from the TEMPOS study (France) reveal a massive shift toward anti-CD20 therapies — especially Ofatumumab.

  • And finally, how a new AI-based prediction tool helps estimate individual risk when stopping a DMT.

🎯 Main takeaway: MS treatment is moving toward earlier, stronger, and more personalized approaches — guided by real-world evidence and smart technology.

👉 You can read the full article with all study details, numbers, and takeaways here: https://ms-perspektive.de/en/140-ectrims-rwe

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See you soon and try to make the best out of your life,
Nele

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Episoder(174)

#172: AI for MS. How the CLAIMS Project Could Transform MS Care – with Prof. Friedemann Paul

#172: AI for MS. How the CLAIMS Project Could Transform MS Care – with Prof. Friedemann Paul

In this episode, Prof. Friedemann Paul from Charité – Universitätsmedizin Berlin, Germany, explains how the European CLAIMS project aims to improve multiple sclerosis care through AI-assisted decision...

24 Jun 35min

#171: The Gut-Brain Axis in Multiple Sclerosis. Interview with Prof. Dr. Anne-Katrin Pröbstel

#171: The Gut-Brain Axis in Multiple Sclerosis. Interview with Prof. Dr. Anne-Katrin Pröbstel

The gut–brain axis in multiple sclerosis is an exciting field of research that connects the gut microbiome, immune system and central nervous system. In this interview, Prof. Dr. Anne-Katrin Pröbstel ...

17 Jun 19min

#170: Vaccinations and MS – What You Need to Know with Dr. Thomas Grüter

#170: Vaccinations and MS – What You Need to Know with Dr. Thomas Grüter

In this episode, Nele talks with neurologist Dr. Thomas Grüter about vaccinations and multiple sclerosis. The original interview was published in German in December 2024. This English version has been...

10 Jun 15min

#169: Multiple Sclerosis in Nepal. Diagnosis, Treatment and Access to Care

#169: Multiple Sclerosis in Nepal. Diagnosis, Treatment and Access to Care

In this episode, Nele speaks with Dr. Ayush Chandra and Dr. Avinash Chandra about multiple sclerosis in Nepal. They explain why MS is still often diagnosed late, how limited access to MRI, neurologist...

3 Jun 58min

#168: From Fragmented Care to Connected Care: The MS360° Approach with Dr. Isabel Voigt

#168: From Fragmented Care to Connected Care: The MS360° Approach with Dr. Isabel Voigt

In this episode, Dr. Isabel Voigt from the MS Center Dresden introduces the MS360° approach, a digital-first hybrid care model designed to make multiple sclerosis care more continuous, proactive, and ...

27 Mai 33min

#167: Living with MS: Fatigue, Walking & Energy — Insights from Sanam

#167: Living with MS: Fatigue, Walking & Energy — Insights from Sanam

In episode #167, Sanam Saeedi shares her perspective on living with MS, fatigue, walking and energy. Diagnosed in 2019, she explains how symptoms such as foot drop, balance issues and fatigue changed ...

20 Mai 28min

#166: Unseen MS Symptoms: A Patient Expert's Perspective from Iceland with Hjördís Ýrr Skúladóttir

#166: Unseen MS Symptoms: A Patient Expert's Perspective from Iceland with Hjördís Ýrr Skúladóttir

What are unseen MS symptoms really like? In this inspiring episode, Hjördís Ýrr Skúladóttir from Iceland shares her personal journey with multiple sclerosis, from diagnosis and burnout to becoming a p...

13 Mai 48min

#165: MS Doesn't Define Me – How Patti Bevilacqua Turned Multiple Sclerosis into a Life of Purpose

#165: MS Doesn't Define Me – How Patti Bevilacqua Turned Multiple Sclerosis into a Life of Purpose

What does it really mean to live a meaningful life with multiple sclerosis? In this episode, Patti Bevilacqua shares her deeply personal journey after being diagnosed with MS at just 22 years old. Ins...

6 Mai 49min

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