The Underpinnings of Aging and What to Do About It

The Underpinnings of Aging and What to Do About It

The secret to living better for longer starts with removing the cells that make you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver pulls back the curtain on senolytics, showing how to clear senescent cells and build you back up with mitochondria, hormones, and targeted peptides.


Want to age in reverse? Start by clearing out the cells making you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver reframes longevity around one simple idea, which is that you remove what ages you and then rebuild what keeps you young. He explains how senescent cells accumulate, why they become inflammatory factories, and how fasting and senolytics can clear the backlog. He then shows how to protect and upgrade mitochondria, why telomeres work as a useful marker rather than a destiny, and where peptides belong. The result is a stepwise, precision plan that starts with clearance, moves into cellular energy, and finishes with targeted repair for brain, skin, hair, and whole-body performance. Watch the full episode now and learn how to start clearing the cells that make you old.


Dr. Joseph Cleaver is a board-certified internist and fellow in anti-aging and metabolic medicine who blends preventive lifestyle medicine, regenerative therapeutics, and peptide science. He teaches clinicians nationwide and sees patients through the Paradigm Wellness Medical Group. He also hosts small-group masterminds on longevity and regenerative medicine at his winery in Sonoma.


Dr. Joseph Cleaver

Website: www.pwmgmed.com

Integrative Peptides

Website: ⁠⁠⁠⁠⁠⁠https://integrativepeptides.com/⁠⁠⁠⁠⁠⁠

Facebook: ⁠⁠⁠⁠⁠⁠https://www.facebook.com/integrativepeptidesofficial/⁠⁠⁠⁠⁠⁠

Instagram: ⁠⁠⁠⁠⁠⁠https://www.instagram.com/integrativepeptides/⁠⁠⁠⁠⁠⁠

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Holtorf Medical Group

Website: ⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠

Facebook: ⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠

Instagram: ⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠

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Kent Holtorf, MD

YouTube: ⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠

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Produced by DrTalks

⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

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Episoder(68)

Unlock the Secrets to Longevity and Chronic Illness With 3rd Generation Oral Peptides

Unlock the Secrets to Longevity and Chronic Illness With 3rd Generation Oral Peptides

I keep coming back to one idea in this talk: the immune system is not a side character in aging and chronic illness—it is closer to the director. I lay out the teeter-totter first: the TH1 and regulat...

9 Sep 56min

Breakthroughs in Longevity Science and Aesthetics from the Inside Out with Oral Peptide Bioregulators

Breakthroughs in Longevity Science and Aesthetics from the Inside Out with Oral Peptide Bioregulators

I did not plan to give this talk. I arrived at the AIMS Symposium, realized how much of the room was aesthetics, and did not have a single slide on the oral skin bioregulators we have been working on ...

26 Aug 40min

A Multi System Treatment Approach to Traumatic Brain Injury, PTSD & Neurodegenerative Disease Using Peptides

A Multi System Treatment Approach to Traumatic Brain Injury, PTSD & Neurodegenerative Disease Using Peptides

A head injury does not stay in the head. In this episode of Peptides and Longevity, I share the talk I gave for Boston BioLife on treating traumatic brain injury, post-traumatic stress, and neurodegen...

13 Aug 43min

The Hidden Reason Your Immune System Ages Faster 

The Hidden Reason Your Immune System Ages Faster 

Aging may begin in the immune system long before symptoms appear. In this Peptides and Longevity episode, Dr. Kent Holtorf breaks down the science behind peptides, immune balance, inflammation, mitoch...

13 Mai 46min

The 5-Day Reset That Calms Cravings

The 5-Day Reset That Calms Cravings

Fasting isn’t just willpower, it’s a cellular switch. In this Peptides and Longevity episode, nutrition professional Renee Fitton breaks down how fasting mimicking supports deep cellular cleanup, meta...

29 Apr 39min

Peptides, Faith, and the Truth About Weight Loss

Peptides, Faith, and the Truth About Weight Loss

What if weight loss isn’t about willpower, but restoring what your body lost along the way? In this episode of Peptides and Longevity, Dave Knapp shares his journey through obesity, type 2 diabetes, G...

15 Apr 47min

Why Great Pharmacists Still Struggle to Stay Open

Why Great Pharmacists Still Struggle to Stay Open

Independent pharmacies are filling prescriptions at a loss, and most people have no idea. In this episode of the Peptides and Longevity Podcast, Dr. Lisa Faast breaks down why margins are getting crus...

1 Apr 31min

Practicing Medicine Freely Through the PMA Model

Practicing Medicine Freely Through the PMA Model

What if healthcare practitioners could serve people more freely while preserving patient choice? In this episode of Peptides and Longevity, Michael Blake, founder of Forgotten Formula, explains Privat...

18 Mar 25min

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