November 25, 2025: Clonal Hematopoiesis, Alcohol and Blood Pressure, Long-Term Risk, and Emerging Biomarkers | JACC This Week
JACC This Week17 Nov 2025

November 25, 2025: Clonal Hematopoiesis, Alcohol and Blood Pressure, Long-Term Risk, and Emerging Biomarkers | JACC This Week

JACC's November 25, 2025 issue kicks off Thanksgiving week with JACC Editor-in-Chief Harlan M. Krumholz, MD, SM, reflecting on his editor's page and the day he became a doctor (0:12). For original research articles, he discusses a study on colchicine & clonal hematopoiesis, an exploratory study of the LoDoCo2 trial (1:10), and a paired editorial comment with more perspectives and a reminder of the upcoming COLCOT trial (4:33). Next, a study on Lp(a) and IL-6 (4:54) and an editorial (6:12), 30-year CVD risk percentiles based on the PREVENT equations (6:30), and an accompanying editorial from JACC Deputy Editor Erica Spatz, MD, on next-generation strategies to encourage healthier behaviors (7:35). Other studies and editorials include a fascinating look at alcohol and blood pressure (8:04) and reinforcing the WHO public health guidance (10:05); remnant cholesterol in young adults (10:38) and implications for cholesterol guidelines (12:36). We also include four brief reports on RSV vaccine (13:11), long Covid (13:43), Lp(a) levels (14:06), the predictive power of polygenic risk scores (14:58), a viewpoint on US veterans (15:36), and our regular Amara Yad image (15:53), which we're delighted to be able to continue to promote with JACC: Clinical Electrophysiology Editor-in-Chief Kalyanam Shivkumar, MD.

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Episoder(729)

Season 2 Wrap-Up: Thank You, Reflections, and What Comes Next | JACC This Week

Season 2 Wrap-Up: Thank You, Reflections, and What Comes Next | JACC This Week

In this special Season 2 wrap-up of JACC This Week, Dr. Harlan Krumholz and Dr. Carolyn Lam reflect on the pilot season, the energy of ACC.26, and what they've learned from listeners along the way. Fr...

7 Apr 4min

March 31, 2026: Global Cardiovascular Insights & Breakthroughs from China | JACC This Week

March 31, 2026: Global Cardiovascular Insights & Breakthroughs from China | JACC This Week

This week's edition of JACC This Week brings Dr. Carolyn Lam and Dr. Harlan Krumholz into a deep exploration of a special issue devoted to innovative cardiovascular research emerging from China. As th...

31 Mar 19min

March 24, 2026: Cardiometabolic Health, COVID Impact & Prevention Science | JACC This Week

March 24, 2026: Cardiometabolic Health, COVID Impact & Prevention Science | JACC This Week

Drs. Carolyn Lam and Harlan Krumholz unpack new JACC research on cardiometabolic health, highlighting how COVID‑19 shaped cardiovascular care, mortality patterns, and disparities. They also break down...

24 Mar 13min

March 17, 2026: Heart Failure, Chagas Research & AI in Cardiology | JACC This Week

March 17, 2026: Heart Failure, Chagas Research & AI in Cardiology | JACC This Week

In this episode, Dr. Carolyn Lam and Dr. Harlan Krumholz break down key studies from this week's JACC issue, including new evidence on Chagas‑related heart failure, updated diastolic function guidelin...

17 Mar 17min

March 10, 2026: Inside JACC Stats: The State of CV Health in Focus | JACC this Week

March 10, 2026: Inside JACC Stats: The State of CV Health in Focus | JACC this Week

Dr. Carolyn Lam and Dr. Harlan Krumholz sit down with Dr. Rishi Wadhera to unpack the first-ever JACC Cardiovascular Statistics issue. They explore why this annual report matters, the key trends in U....

10 Mar 18min

March 3, 2026: Hypertrophic Cardiomyopathy  in Focus—MAPLE-HCM Trial, Myosin Inhibitors & What Improvement Really Means | JACC This Week

March 3, 2026: Hypertrophic Cardiomyopathy in Focus—MAPLE-HCM Trial, Myosin Inhibitors & What Improvement Really Means | JACC This Week

In this episode of JACC This Week, Dr. Carolyn Lam and Dr. Harlan Krumholz spotlight a mini-focus issue on hypertrophic cardiomyopathy (HCM), a field undergoing rapid transformation. The discussion ce...

3 Mar 18min

February 24, 2026: ACHD Guideline in Focus—From Survival to Stewardship | JACC This Week

February 24, 2026: ACHD Guideline in Focus—From Survival to Stewardship | JACC This Week

In this episode of JACC This Week, Dr. Carolyn Lam and Dr. Harlan Krumholz spotlight the 2025 Adult Congenital Heart Disease (ACHD) Guidelines and explore what they signal for the future of cardiovasc...

24 Feb 13min

JACC This Week Bonus Episode – Women's Cardiovascular Health: From Inclusion to Redesign

JACC This Week Bonus Episode – Women's Cardiovascular Health: From Inclusion to Redesign

This bonus episode continues the conversation from the JACC Women's Cardiovascular Health Issue, moving from science to systems. In this extended discussion, Drs. Carolyn Lam and Harlan Krumholz are j...

17 Feb 14min

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