241: Wagyu T2T reveals a cattle X neocentromere
Pineda PS et al., Nature Communications - A telomere-to-telomere Wagyu assembly uncovers a natural neocentromere on the cattle X formed by inverted repeats and transposable element expansion, adds hun...
27 Des 202518min
240: CYFIP1 controls cortical axon development by modulating calcium
Ricci C et al., Nature Communications - Reduction of CYFIP1 delays callosal axon growth and arborization by lowering intracellular calcium and impairing mitochondrial function. Key terms: cyfip1, axon...
26 Des 202518min
239: Genomic Adaptations of the Svalbard Reindeer
Genome Biology and Evolution - The Genomic Basis of the Svalbard Reindeer’s Adaptation to an Extreme Arctic Environment Music:Enjoy the music based on this article at the end of the episode. Article...
25 Des 202519min
238: Germline polymorphisms shape antibody light chain repertoires
Engelbrecht E et al., Nat Commun - Long-read sequencing of IGK and IGL paired with AIRR-seq shows that common germline SNVs, SVs, and alleles drive inter-individual differences in light chain gene usa...
24 Des 202518min
237: Tracing enteric pathogens in Africa with metagenomics and WGS
Thystrup C et al., Nat Commun (2025) - This study combines whole-genome sequencing and metagenomics to map the diversity, abundance, and genomic relationships of enteric foodborne pathogens across hum...
23 Des 202520min
236: XPD translocation and genetic disease etiology
Paul T et al., Nat Commun - Computational modeling reveals how ATP-driven conformational cycles of the XPD helicase drive directional 5′→3′ translocation on single-stranded DNA and how mutations disru...
22 Des 202519min
235: Maternal H3K9 methyltransferases control aRMAE in C. elegans
Sands et al., Nature Communications - Using dual-color reporters in C. elegans, the study shows maternal H3K9 methyltransferases MET-2 and SET-25 antagonistically regulate autosomal random monoallelic...
21 Des 202517min
234: MTHFR genotype and methionine metabolism predict COVID-19 severity
Petrova B et al., Proc Natl Acad Sci U S A - IMPACC longitudinal metabolomics and genomics analyses show that disruptions in one‑carbon/methionine metabolism together with MTHFR C677T genotype at hosp...
20 Des 202520min
