177: Biallelic MCM8/MCM9 Variants: From Hypogonadism to Cancer Predisposition
️ Episode 177: Biallelic MCM8/MCM9 Variants: From Hypogonadism to Cancer Predisposition In this episode of PaperCast Base by Base, we explore a multi‑cohort clinical–genomic study that delineates the...
24 Okt 202517min
176: FAHD1 and the Pyruvate-Driven Evolution of Hepatocellular Carcinoma
️ Episode 176: FAHD1 and the Pyruvate-Driven Evolution of Hepatocellular Carcinoma In this episode of PaperCast Base by Base, we explore how multi-omics integration—spanning single-cell transcriptomi...
23 Okt 202519min
175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk
️ Episode 175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk In this episode of PaperCast Base by Base, we explore how enhancer–promoter 3D chromatin maps from five primary ...
22 Okt 202519min
174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility
️ Episode 174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility In this episode of PaperCast Base by Base, we explore a PNAS study revealing how TMEM217 forms a complex wi...
21 Okt 202516min
173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset
️ Episode 173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset In this episode of PaperCast Base by Base, we explore a PNAS study showing how a synthetic bottlebrush block copolyme...
20 Okt 202520min
172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense
️ Episode 172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense In this episode of PaperCast Base by Base, we explore a PNAS study showing that short, previously nongenic DNA sequ...
19 Okt 202519min
171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?
Danchuk S et al., Proceedings of the National Academy of Sciences - Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier? Music:Enjoy the music based on this article at...
18 Okt 202516min
170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans
Picchetta L et al., The American Journal of Human Genetics - Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans Music:Enjoy the music based on this article at the end of the episode...
17 Okt 202517min
