398: Modeling JAK2V617F Clonal Expansion in the General Population
Snyder J et al., Proceedings of the National Academy of Sciences (PNAS) - Longitudinal VAF measurements from 67 JAK2V617F-positive participants in the Danish GESUS study were analyzed with a Moran-pro...
21 Jun 24min
397: SciPhy: Bayesian phylogenetics for sequential genetic lineage tracing
Seidel et al., Nature Communications - SciPhy is a BEAST2-integrated Bayesian framework that models sequential CRISPR‑based insertion edits to jointly infer time-scaled single-cell lineage trees, edit...
20 Jun 23min
396: Physical homology recognition between DNA duplexes
Stannard A et al., Proceedings of the National Academy of Sciences (PNAS) - This episode summarizes a PNAS study that uses a FRET-responsive DNA tweezers nanosensor to detect and quantify sequence-dep...
18 Jun 23min
395: Extended sequence context shapes mutational bias in Escherichia coli
Green R et al., PNAS - Collating >100,000 base-pair substitutions from 32 mutation-accumulation experiments, this study shows that sequence context well beyond adjacent bases — up to ±6 bp and even hu...
18 Jun 22min
394: Benchmarking LLMs for cfRNA biomarker discovery
Gaudio HA et al., Nature Communications - This episode examines a systematic benchmark of six commercial large language models applied to plasma cell-free RNA across three clinical cohorts, assessing ...
17 Jun 22min
393: Hidden Resistance: tNGS Reveals Rifampicin and Bedaquiline Resistance in Eswatini
Vambe D et al., Nature Communications - This study reports the programmatic introduction of targeted next-generation sequencing (tNGS) in Eswatini and shows that tNGS detected large amounts of rifampi...
17 Jun 21min
392: GWAS of Cocaine Self-Administration in Heterogeneous Stock Rats
Lara MK et al et al., Nature Communications - Large GWAS in 836 outbred HS rats identifies six loci linked to cocaine self-administration traits, highlighting Ces1 carboxylesterase genes and other loc...
12 Jun 23min
391: The Kaufmann Protocol — Why We Age and How to Stop It
Dr. Sandra Kaufmann, The Kaufmann Anti-Aging Institute - Dr. Sandra Kaufmann — physician, scientist and athlete — set out to understand aging and fight it with science. This episode is a guided overvi...
12 Jun 1h 6min
