Statistics in Pharmacokinetics (Ep. 49)
In this episode I discuss review statistics that are commonly used in pharmacokinetics and pharmacometrics work. I reviewed the basic theory of the normal distribution and then discussed various indiv...
22 Sep 202525min
Clinical Trial Simulations (Ep. 48)
In this episode I discuss clinical trial simulations. I review concepts of trial simulation including different variability terms and when to use them. I also share my thoughts on 3 different applicat...
25 Aug 202521min
Using R Shiny for Clinical Pharmacology (Ep. 47)
In this episode I discuss R Shiny and how it can be used for building clinical pharmacology tools. I provide an overview of the technology, suggest a few example use cases, and then walk through a spe...
28 Jul 202519min
What is useful about noncompartmental analysis? (Ep. 46)
In this episode I discuss noncompartmental analysis. I categorize PK parameters calculated by NCA methods as either Important, Useful, or Questionable. I also share my thoughts on how to report PK par...
23 Jun 202527min
How to select a base PK model (Ep. 45)
In this episode I review the process I follow for fitting a base pharmacokinetic (PK) model. I talk from the perspective of an individual PK model, but include some differences associated with populat...
27 Mai 202527min
Different estimation methods used in modeling (Ep. 44)
In this episode I discuss different algorithms used for pharmacometrics modeling. I describe difference between maximum likelihood and expectation maximization methods. I review the FO and FOCEI maxim...
21 Apr 202525min
What is consulting life like? (Ep. 43)
In this episode I discuss my experience as an independent consultant in the clinical pharmacology and pharmacometrics space. I talk about how I got from high school to become a consultant. I touched o...
24 Mar 202530min
Population PK modeling with nlmixr (Ep. 42)
In this episode I discuss using nlmixr for population PK modeling in R. I give an overview of the software package, describe the installation process, and walk through a simple example. Overall, nlmix...
24 Feb 202525min
