QSP Modeling with Ahmed Elmokadem (Ep. 51)
In this episode I chat with Ahmed Elmokadem about QSP modeling. Ahmed, from Metrum Research Group, is an expert consultant in QSP modeling and how it can be used to provide a framework to connect mech...
24 Nov 202544min
CDISC datasets and ACoP 2025 (Ep. 50)
In this episode I discuss dataset-JSON, a new proposed data standard for CDISC files and explain some of the CDISC files I use in my clinical pharmacology work. I end with some brief thoughts about th...
27 Okt 202518min
Statistics in Pharmacokinetics (Ep. 49)
In this episode I discuss review statistics that are commonly used in pharmacokinetics and pharmacometrics work. I reviewed the basic theory of the normal distribution and then discussed various indiv...
22 Sep 202525min
Clinical Trial Simulations (Ep. 48)
In this episode I discuss clinical trial simulations. I review concepts of trial simulation including different variability terms and when to use them. I also share my thoughts on 3 different applicat...
25 Aug 202521min
Using R Shiny for Clinical Pharmacology (Ep. 47)
In this episode I discuss R Shiny and how it can be used for building clinical pharmacology tools. I provide an overview of the technology, suggest a few example use cases, and then walk through a spe...
28 Jul 202519min
What is useful about noncompartmental analysis? (Ep. 46)
In this episode I discuss noncompartmental analysis. I categorize PK parameters calculated by NCA methods as either Important, Useful, or Questionable. I also share my thoughts on how to report PK par...
23 Jun 202527min
How to select a base PK model (Ep. 45)
In this episode I review the process I follow for fitting a base pharmacokinetic (PK) model. I talk from the perspective of an individual PK model, but include some differences associated with populat...
27 Mai 202527min
Different estimation methods used in modeling (Ep. 44)
In this episode I discuss different algorithms used for pharmacometrics modeling. I describe difference between maximum likelihood and expectation maximization methods. I review the FO and FOCEI maxim...
21 Apr 202525min
