From First Principles

Hosted by Lester Nare and Krishna Choudhary, this episode spans astrophysics, forensic chemistry, and neuroimmunology. We begin with a deep dive into 3I/ATLAS, only the third confirmed interstellar ob...

27 Nov 20251h 27min

Hosted by Lester Nare and Krishna Choudhary, this episode dives into three breakthroughs stretching across aerospace engineering, astrobiology, and quantum computing. We start with a Nature Communicat...

22 Nov 20251h 32min

Hosted by Lester Nare and Krishna Choudhary, this super-episode spans four wildly different frontiers: bioengineers hijacking bacterial evolution to mass-produce octopus camouflage pigment; orcas deve...

13 Nov 20251h 17min

AI, Eyes, and the Sky — From Synthetic Genomes to Restored Vision and Cosmic MysteriesHosted by Lester Nare and Krishna Choudhary, this episode of From First Principles explores three cutting-edge bre...

6 Nov 20252h 3min

Hosted by Lester Nare and Krishna Choudhary, this episode tells the story of Nobel laureate Chen Ning Yang and how his ideas on symmetry and gauge theory transformed modern physics.Summary• Early Year...

31 Okt 20251h 43min

Aloha internet — Lester Nare and Krishna Choudhary return with three extraordinary research stories: portable muon beams, sodium-ion batteries, and the secret to long life.Summary• Lawrence Berkeley’s...

23 Okt 20251h 36min

After a packed week of Nobel Prize coverage, Lester and Krishna look back on how From First Principles began and why they built it as an “ESPN for Science.” They revisit 2025’s Medicine, Physics and C...

15 Okt 20251h 12min

Hosted by Lester Nare and Krishna Choudhary, this one-episode special brings all three 2025 Nobel Prizes in the sciences into a single listen: Medicine (immune tolerance and FOXP3), Physics (macroscop...

9 Okt 20251h 54min