From First Principles

From First Principles

From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.

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Episoder(63)

Optovolution: Teaching Proteins to Think Like Computers (EP. 31)

Optovolution: Teaching Proteins to Think Like Computers (EP. 31)

Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into a new synthetic-biology breakthrough out of EPFL: OptoEvolution. The big idea is simple but powerful — traditional directe...

18 Mar 55min

Can We Stop an Asteroid? The Physics Behind NASA’s DART Mission (EP. 30)

Can We Stop an Asteroid? The Physics Behind NASA’s DART Mission (EP. 30)

Hosted by Lester Nare and Krishna Choudhary, this episode is a full deep dive on planetary defense. We break down NASA’s DART mission, why the goal was never to “blow up” an asteroid but to gently nud...

16 Mar 54min

Astrobiology’s Biggest Survival Test + A Vaccine Against Everything? (EP. 29)

Astrobiology’s Biggest Survival Test + A Vaccine Against Everything? (EP. 29)

Hosted by Lester Nare and Krishna Choudhary, this episode starts in astrobiology with a fresh experimental challenge to one of the biggest objections to lithopanspermia: can life actually survive the ...

12 Mar 2h 4min

Dark Galaxies, Fuzzy Dark Matter, and an Alzheimer’s Breakthrough (EP. 28)

Dark Galaxies, Fuzzy Dark Matter, and an Alzheimer’s Breakthrough (EP. 28)

Hosted by Lester Nare and Krishna Choudhary, this episode has two main stories: an astrophysics update on a candidate “dark galaxy” in the Perseus Cluster (a halo that’s ~99.9% dark matter), and a maj...

4 Mar 1h 51min

Dream Engineering, the Proton Radius Puzzle, and an ALS Breakthrough (EP. 27)

Dream Engineering, the Proton Radius Puzzle, and an ALS Breakthrough (EP. 27)

Hosted by Lester Nare and Krishna Choudhary, this episode has three main stories: interactive dream engineering (yes, two-way “communication” during lucid dreaming), the proton radius puzzle finally g...

26 Feb 2h 12min

Winter Olympics Deep Dive: Ice Physics, Performance Pressure, and Climate Change (EP. 26)

Winter Olympics Deep Dive: Ice Physics, Performance Pressure, and Climate Change (EP. 26)

Hosted by Lester Nare and Krishna Choudhary, this episode is a Winter Olympics deep dive from first principles—physics, neuroscience, and climate science in one ride.• Why ice is slippery: the “water ...

18 Feb 1h 50min

Plants, Quantum Sensors, and Predicting Cancer Evolution (EP. 25)

Plants, Quantum Sensors, and Predicting Cancer Evolution (EP. 25)

Hosted by Lester Nare and Krishna Choudhary, this episode jumps from plant biochemistry to quantum metrology to cancer evolution. We start with a University of York breakthrough that solves a ~50-year...

10 Feb 1h 49min

Artemis II, Apollo, and the Physics of Going Back to the Moon (EP. 24)

Artemis II, Apollo, and the Physics of Going Back to the Moon (EP. 24)

Hosted by Lester Nare and Krishna Choudhary, this episode is a full-spectrum moonshot: why Artemis II matters, how the mission actually works (SLS, Orion, translunar injection, free-return trajectorie...

4 Feb 1h 9min

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