Addiction as a brain disease revised: why it still matters, and the need for consilience
Nearly 25 years ago, a paper was published about addiction that transformed the field. The director of the US National Institute on Drug Abuse at the time called addiction a “brain disease,” and he wr...
21 Mai 20219min
Big data in psychiatry: multiomics, neuroimaging, computational modeling, and digital phenotyping
The world of medicine has been changing rapidly due to the increasing use of ‘big data.’ And there’s been a major revolution in this approach in neuroscience and psychiatry as well: computing power, s...
19 Mar 20219min
Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects
Interest is growing in the use of the psychedelic drug LSD for psychiatric research and even potentially for treatment. But placebo-controlled studies conducted to date have used just one dose of the ...
19 Jan 20219min
Big behavior: challenges and opportunities in a new era of deep behavior profiling
Scientists who study neuropsychiatric conditions and treatments often use rodent models to do so. From depression to anxiety to memory impairment and impulsivity, there are certain rodent behaviors th...
4 Nov 20209min
Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders
The application of the study of genetics and the use of big data to identify patterns of inheritance as well as de novo mutations has had a dramatic impact on the field of Autism Spectrum Disorder res...
23 Sep 20209min
Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain
It’s understood in epidemiological research that women who experience trauma during puberty are at significantly higher risk for affective disorders such as depression and anxiety when they become pre...
10 Jul 20209min
Social networking and mental health: looking beyond frequency of use and towards mechanisms of action
Over the past decades, there’s clearly been a dramatic increase in the amount of time people spend online using social networking sites. For instance, Facebook and Instagram have literally billions of...
15 Mai 20209min
Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects
A number of drugs that are used recreationally are now being studied for their use in psychopharmacology. But while the ways in which these drugs are similar or different has been described anecdotall...
6 Mar 20209min
