Episode 318: 317. METHODS MONDAY- What is a Confounder?
Be careful, most observational data have a large amount of confounders not accounted for and even when accounted for you can never account for all the confounders
15 Jul 202410min
Episode 317: 316. Guideline for the Management of Lower Extremity Peripheral Artery Disease
https://www.ahajournals.org/doi/10.1161/CIR.0000000000001251. Diagnosis:To establish a PAD diagnosis, the resting ankle–brachial index (ABI) remains the initial test of choice in patients with suggest...
10 Jul 20245min
Episode 316: 315. Prognostic Value of Cardiovascular Biomarkers in the Population
https://jamanetwork.com/journals/jama/article-abstract/2818624Conclusion--“Cardiovascular biomarkers were strongly associated with fatal and nonfatal cardiovascular events and mortality. The addition ...
9 Jul 20246min
Episode 315: 314. METHODS MONDAY! What Is A C-Score?
What are c statisticsC-statistic gives the probability a randomly selected patient who experienced an event (e.g. a disease or condition) had a higher risk score than a patient who had not experienced...
8 Jul 20247min
Episode 314: 313. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19
https://pubmed.ncbi.nlm.nih.gov/38598573/In fully vaccinated adults with a risk factor or unvaccinated patients without a risk factor who have symptomatic COVID-19, does paxlovid--nirmatrelvir-ritonav...
5 Jul 20245min
Episode 313: 312. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size
https://www.nejm.org/doi/10.1056/NEJMoa2314063Randomized trials have shown the benefit of endovascular thrombectomy in patients with acute stroke due to large-artery occlusion in the anterior circulat...
3 Jul 20247min
Episode 312: 311. Risk of Stroke in Women Using Levonorgestrel-Releasing Intrauterine Device for Contraception
https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.124.047438We studied the risk of IS and ICH in women using LG-IUDs—aka mirana-- compared to women not using hormonal contraceptives. The commonl...
2 Jul 20245min
Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial
A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are desig...
1 Jul 202414min
