Episode 314: 313. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19
https://pubmed.ncbi.nlm.nih.gov/38598573/In fully vaccinated adults with a risk factor or unvaccinated patients without a risk factor who have symptomatic COVID-19, does paxlovid--nirmatrelvir-ritonav...
5 Jul 20245min
Episode 313: 312. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size
https://www.nejm.org/doi/10.1056/NEJMoa2314063Randomized trials have shown the benefit of endovascular thrombectomy in patients with acute stroke due to large-artery occlusion in the anterior circulat...
3 Jul 20247min
Episode 312: 311. Risk of Stroke in Women Using Levonorgestrel-Releasing Intrauterine Device for Contraception
https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.124.047438We studied the risk of IS and ICH in women using LG-IUDs—aka mirana-- compared to women not using hormonal contraceptives. The commonl...
2 Jul 20245min
Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial
A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are desig...
1 Jul 202414min
Episode 310: 309. Hospital-Associated Venous Thromboembolism Prophylaxis Use by Risk Assessment
https://shmpublications.onlinelibrary.wiley.com/doi/abs/10.1002/jhm.13350Xu J et al. Hospital-associated venous thromboembolism prophylaxis use by risk assessment at a large integrated health care net...
28 Jun 20248min
Episode 309: 308. Mailed feedback to Primary Care Physicians on Antibiotic Prescribing
https://www.bmj.com/content/385/bmj-2024-079329Overprescription of antibiotics by primary care clinicians is a major modifiable driver of antibiotic resistance. Evidence suggests that peer-comparison ...
27 Jun 20247min
Episode 308: 307. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES)
Kityo C et al. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES): Week 48 results from a randomised, multicentre, open-label, non-inferio...
25 Jun 20245min
Episode 307: 306. METHODS MONDAY! What is the 95% Confidence Interval?
95% CI does NOT mean there is a 95% chance the true value is in the interval. It means that if you continually resample, 95% of your confidence intervals (which will vary every time you resample), wil...
24 Jun 20248min
