Episode 257: 256. EMPEROR-Reduced- Cardiovascular Outcomes with Empagliflozin in Heart Failure
NNT of 20 to prevent 1 hospitalization at 16 months of follow upThey composite outcome was driven by decrease hospitalizations NOT deathhttps://www.nejm.org/doi/full/10.1056/NEJMoa2022190
14 Mar 20249min
Episode 256: 256. DAPA-HF- Dapagliflozin and Heart Failure with Reduced Ejection Fraction - DAPA-HF
NNT of 21 over 18 months to prevent a composite of worsening heart failure or cardiovascular deathNNT for hospitalization = 27NNT for Cardiovascular Death = 53N Engl J Med 2019; 381:1995-2008
13 Mar 20248min
Episode 255: 255. Dapagliflozin and Heart Failure with Preserved Ejection Fraction
Dapagliflozin and HFpEF did happen to improve the composite outcome but this was based mainly on hospitalizations not on death and comes at a big price tag with the NNT around 36 at 2.3yrs. N Engl J M...
12 Mar 202410min
Episode 254: 254. Empagliflozin For Heart Failure with Preserved Ejection Fraction- EMPEROR-Preserved
Hospitalization for heart failure occurred in 8.6% of patients in the empagliflozin group and 11.8% patients in the placebo group (hazard ratio, 0.71; 95% CI, 0.60 to 0.83)number needed to treat [NNT]...
8 Mar 20248min
Episode 253: 253. EMPA-REG OUTCOME - Type 2 Diabetes and Empagliflozin- How Much Money To Save How Many People?
EMPA-REG OUTCOME back in 2015 this was the first SGLT2 trial to set the world on fire with Primary Outcome: death from cardiovascular causes: NNT 46 per 3.1 yrs (at $600 a month, 1 million dollars per...
7 Mar 202410min
Episode 252: 252. After Admission to the ICU How Many Patients Remain on a PPI?
Forty-two percent of patients had a PPI on their medication list without indication 8 weeks after discharge, and more than half of these patients still were using PPIs 1 year later. Compared with pro...
6 Mar 20247min
Episode 251: 251. Does Weight/BMI Change DOAC Efficacy?
These results are reassuring for management of both underweight and overweight patients with AF. That said, I would still have reservations about prescribing DOACs in the small minority of patients wi...
5 Mar 20245min
Episode 250: 250. Do Nurse Practitioners Prescribe More or Less Medications From the Beers List?
Nurse Practitioners prescribe medications off the beers list at the same rate at primary care physicians, hard to tell what this means for patient care and patient outcomes. https://www.acpjournals.or...
1 Mar 20245min
