19. Biological Aging Clocks, mTOR & Rapamycin: A Reality Check with Dr. Matt Kaeberlein

19. Biological Aging Clocks, mTOR & Rapamycin: A Reality Check with Dr. Matt Kaeberlein

In this episode of MD Longevity Lab: Playing the Long Game, Drs. Nisha and Vikas Patel sit down with world-leading aging researcher Dr. Matt Kaeberlein to cut through the noise in longevity medicine.We discuss why most biological aging clocks fall short, what mTOR actually does, how rapamycin works (and why it’s widely misunderstood), what truly moves the needle for healthspan, and where AI and preventive medicine are headed.This is an evidence-based conversation focused on clarity, nuance, and long-term thinking—without the hype.Topics Covered • Why biological aging clocks are unreliable at the individual level • mTOR explained and its role in aging biology • Rapamycin: risks, benefits, and unknowns • Fasting and caloric restriction myths • What actually improves healthspan (exercise, sleep, connection, hormones) • AI, wearables, and the future of longevity care • The Dog Aging Project and slowing aging in companion animals About Our GuestDr. Matt Kaeberlein, PhD is a world-renowned scientist in the biology of aging, founder of Optispan, and co-founder of the Dog Aging Project. He is known for prioritizing evidence over hype and for advancing translational longevity science.Links & Resources • Follow Dr. Matt Kaeberlein: @mkaeberlein • Optispan & the Optispan Podcast: https://www.optispan.com https://www.dogaginginstitute.org • MD Longevity Lab: https://www.mdlongevitylab.com • Watch on YouTube (MD Longevity Lab Podcast): https://www.youtube.com/@MDLongevityLab Dr. Kaeberlein also hosts the Optispan Podcast, available on YouTube and all major podcast platforms. If you’d like to support his valuable work advancing longevity science in companion animals, donations to the Dog Aging Institute (a 501(c)(3) nonprofit) are tax-deductible and help make this research possible.

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Avsnitt(37)

37. Environmental Curveballs: Sorting Real Toxin Exposure Risk From the Noise

37. Environmental Curveballs: Sorting Real Toxin Exposure Risk From the Noise

Wildfire smoke. Cyclospora. Microplastics. Seed oils. Gas stoves. Every environmental scare that'll trend on your feed six weeks from now. Dr. Vikas Patel and Dr. Nisha Patel give you a four-question ...

27 Aug 51min

36. Why Dementia Prevention Beats Treatment: APOE Testing, Women's Brain Health, and the Levers You Control

36. Why Dementia Prevention Beats Treatment: APOE Testing, Women's Brain Health, and the Levers You Control

If you live into your mid-eighties, your odds of dementia are roughly one in three. Most people spend zero minutes of midlife thinking about it — and Dr. Vikas Patel and Dr. Nisha Patel make the case ...

13 Aug 1h 5min

35. The Over-40 Injury Playbook: How to Prevent and Rehab Injuries When Life Hands You Lemons

35. The Over-40 Injury Playbook: How to Prevent and Rehab Injuries When Life Hands You Lemons

Anyone over 40 who's felt a tendon go knows the sound — and the sinking feeling right after. Why midlife makes us injury-prone: sedentary weekdays, weekend-warrior spikes, unstructured training, and m...

30 Juli 1h 22min

34. How the Blue Zones Have Mastered Longevity: No Peptides, Just the Basics

34. How the Blue Zones Have Mastered Longevity: No Peptides, Just the Basics

The Blue Zones are the five places on Earth where people routinely live to 100 in good health, without trying — Okinawa, Sardinia, Loma Linda, Nicoya, and Ikaria. They share almost nothing in common e...

16 Juli 51min

33. Your Health Is Their Inheritance: What Happens to Your Kids When You Don't Take Care of Yourself

33. Your Health Is Their Inheritance: What Happens to Your Kids When You Don't Take Care of Yourself

The longevity space has earned a reputation for being self-absorbed — biohacker bros optimizing their bloodwork while the rest of us live actual lives. In a word: selfish. This episode is the rebuttal...

2 Juli 55min

32. The Muscle Playbook: Preservation, Building, and Progressive Overload

32. The Muscle Playbook: Preservation, Building, and Progressive Overload

There is more conflicting advice about muscle out there than almost any other topic in fitness — what to eat, how much to lift, how often, how heavy, whether older adults should even be lifting at all...

18 Juni 1h 10min

31. The Evidence-Based Supplement Guide: Cutting Through the $60 Billion Noise

31. The Evidence-Based Supplement Guide: Cutting Through the $60 Billion Noise

The supplement industry is a $60 billion business with almost no regulatory oversight. Three out of four American adults take at least one. Almost none of them know what's actually in the bottle.In th...

4 Juni 56min

30. The Delay Game: How Health Insurance Abandoned Your Healthcare & Why The Long Game of Prevention Belongs to You

30. The Delay Game: How Health Insurance Abandoned Your Healthcare & Why The Long Game of Prevention Belongs to You

The American health insurance industry is no longer in the business of paying for your healthcare. It is in the business of delaying it — long enough that someone else has to pay. Usually Medicare. Wh...

21 Maj 49min

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