#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Barry Barish is a theoretical physicist at Caltech and the winner of the Nobel Prize in Physics. Please support this podcast by checking out our sponsors: - MUD\WTR: https://mudwtr.com/lex and use code LEX to get 5% off - GiveDirectly: https://givedirectly.org/lex to get gift matched up to $300 - BiOptimizers: http://www.magbreakthrough.com/lex to get 10% off - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off EPISODE LINKS: Barry's Nobel Prize entry: https://www.nobelprize.org/prizes/physics/2017/barish/facts/ Barry's Caltech profile: https://pma.caltech.edu/people/barry-c-barish LIGO's Website: https://www.ligo.caltech.edu/ LIGO's Twitter: https://twitter.com/LIGO PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:27) - Early Math and Physics questions (18:02) - Enrico Fermi (24:34) - Birth of the Nuclear Age (29:42) - The Fermi Paradox (34:45) - Gravity (51:28) - Philosophical Implications of General Relativity (58:34) - Detecting Gravitational Waves (1:01:47) - LIGO (1:34:45) - Nobel Prize (1:49:34) - Black Holes (2:01:53) - Space Exploration (2:09:48) - Books (2:18:37) - Advice for young people (2:24:33) - Meaning of life

23 Aug 20212h 30min

Joscha Bach is a cognitive scientist, AI researcher, and philosopher. Please support this podcast by checking out our sponsors: - Coinbase: https://coinbase.com/lex to get $5 in free Bitcoin - Codecademy: https://codecademy.com and use code LEX to get 15% off - Linode: https://linode.com/lex to get $100 free credit - NetSuite: http://netsuite.com/lex to get free product tour - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free EPISODE LINKS: Joscha's Twitter: https://twitter.com/Plinz Joscha's Website: http://bach.ai PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:15) - Life is hard (09:38) - Consciousness (16:24) - What is life? (26:33) - Free will (40:38) - Simulation (42:49) - Base layer of reality (58:24) - Boston Dynamics (1:06:43) - Engineering consciousness (1:17:12) - Suffering (1:26:06) - Postmodernism (1:30:25) - Psychedelics (1:43:40) - GPT-3 (1:52:22) - GPT-4 (1:58:47) - OpenAI Codex (2:01:02) - Humans vs AI: Who is more dangerous? (2:17:47) - Hitler (2:22:44) - Autonomous weapon systems (2:30:11) - Mark Zuckerberg (2:35:47) - Love (2:50:00) - Michael Malice and anarchism (3:06:57) - Love (3:11:05) - Advice for young people (3:15:42) - Meaning of life

21 Aug 20213h 18min

Brian Muraresku is the author of The Immortality Key. Please support this podcast by checking out our sponsors: - InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off - GiveWell: https://www.givewell.org/ and use code LEX to get donation matched up to $1k - NI: https://www.ni.com/perspectives - Indeed: https://indeed.com/lex to get $75 credit - MasterClass: https://masterclass.com/lex to get 15% off EPISODE LINKS: Brian's Twitter: https://twitter.com/brianmuraresku Brian's website: https://www.brianmuraresku.com Immortality Key (book): https://amzn.to/3iNYBfB PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:46) - Who or what is God? (25:15) - Terence McKenna's DMT Trips (29:58) - Psychedelics were the source of collective intelligence (40:30) - Psychedelics in ancient alcohol (43:30) - The Immortality Key (46:16) - Jesus and psychedelic wine (58:56) - Role of rituals in human society (1:02:37) - Human confrontation with death (1:05:15) - The future of the human experience (1:17:07) - The role of religion in society (1:22:54) - The future of psychedelics research (1:26:05) - Fasting and meditation as religious experiences (1:29:44) - Neuralink and BCIs (1:36:42) - Is LSD a crutch or an aid in creative work (1:39:21) - Nietzsche said God is dead (1:41:48) - Creatures people meet while on psychedelics (1:47:18) - Consciousness (1:53:41) - Books or movies that made an impact (1:57:39) - Meaning of life

15 Aug 20210s

Matt Walker is a sleep scientist at Berkeley, author of Why We Sleep, and the host of a new podcast called The Matt Walker Podcast. Please support this podcast by checking out our sponsors: - Stamps.com: https://stamps.com and use code LEX to get free postage & scale - Squarespace: https://lexfridman.com/squarespace and use code LEX to get 10% off - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - BetterHelp: https://betterhelp.com/lex to get 10% off - Onnit: https://lexfridman.com/onnit to get up to 10% off EPISODE LINKS: Matt's Podcast: https://themattwalkerpodcast.buzzsprout.com/ Matt's Twitter: https://twitter.com/sleepdiplomat Matt's Instagram: https://www.instagram.com/drmattwalker Matt's Website: https://www.sleepdiplomat.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:56) - Putin moment: Lex takes Matt's sunglasses (10:17) - Fascination with sleep (14:26) - Why do we sleep? (22:58) - Computer vision for driver assistance (32:19) - Consciousness is fundamental (40:25) - Lex on human to robot connection (42:52) - Scent of a Woman is better than "John Wick" (54:33) - Distinction between coffee and caffeine (1:20:17) - The science of 'sleeping on it' (1:34:10) - Lex on his sleeping schedule (1:59:14) - Chronotypes (2:06:44) - How to overcome insomnia (2:24:07) - Diet and sleep (2:33:03) - Where do dreams come from? (2:46:41) - How sleep affects emotions (2:53:35) - Meaning of life

11 Aug 20210s

Luis and Joao Batalha are co-founders of Fermat's Library. Please support this podcast by checking out our sponsors: - Skiff: https://skiff.org/lex to get early access - SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera - Indeed: https://indeed.com/lex to get $75 credit - NetSuite: http://netsuite.com/lex to get free product tour - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off EPISODE LINKS: Fermat's Library Twitter: https://twitter.com/fermatslibrary Luis's Twitter: https://twitter.com/luismbat Joao's Twitter: https://twitter.com/joao_batalha Fermat's Library Website: https://fermatslibrary.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (10:18) - Backstories to research papers (25:09) - Fermat's Library (45:10) - Scientific publishing (1:08:50) - How to read a paper (1:14:44) - Taking good notes (1:23:23) - Favorite papers on Fermat's Library (2:04:14) - Fermat's Library on Twitter (2:13:46) - What it takes to build a successful startup (2:22:43) - Game of Thrones (2:25:30) - Realism in science fiction movies (2:31:29) - Greatest soccer player of all time (2:54:18) - Advice for young people

9 Aug 20213h 2min

Jeff Hawkins is a neuroscientist and cofounder of Numenta, a neuroscience research company. Please support this podcast by checking out our sponsors: - Codecademy: https://codecademy.com and use code LEX to get 15% off - BiOptimizers: http://www.magbreakthrough.com/lex to get 10% off - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium EPISODE LINKS: A Thousand Brain (book): https://amzn.to/3AmxJt7 Numenta's Twitter: https://twitter.com/Numenta Numenta's Website: https://numenta.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (10:35) - Collective intelligence (17:17) - The origin of intelligence in the human brain (30:31) - How intelligent life evolved on Earth (41:30) - Why humans are special in the universe (44:48) - Neurons (49:02) - A Thousand Brains theory of intelligence (57:42) - How to build superintelligent AI (1:15:41) - Sam Harris and existential risk of AI (1:27:43) - Neuralink (1:34:34) - Will AI prevent the self-destruction of human civilization? (1:40:05) - Communicating human knowledge to alien civilizations (1:50:22) - Devil's advocate (1:55:16) - Human nature (2:03:39) - Hardware for AI (2:10:18) - Advice for young people

8 Aug 20212h 25min

Chris Duffin is a strength athlete, coach, and engineer, setting multiple strength world records including squatting and deadlifting 1000 lbs for multiple reps. Please support this podcast by checking out our sponsors: - Headspace: https://headspace.com/lex to get free 1 month trial - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off - Sun Basket: https://sunbasket.com/lex and use code LEX to get $35 off - Ladder: https://ladderlife.com/lex EPISODE LINKS: Chris's Instagram: https://www.instagram.com/mad_scientist_duffin The Eagle and the Dragon (book): https://amzn.to/3Ckpfoj Chris's Website: https://christopherduffin.com Kabuki Strength: https://kabukistrength.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:10) - Performing feats of strength (13:52) - What does it take to lift 1000 lbs for reps? (16:43) - From 500 to 1000lb (17:15) - The mechanics of heavy lifting (28:32) - What did it feel like to do 1000lbs for reps? (30:26) - Achieving peak performance (35:16) - Importance of singular focus (37:48) - Chris's childhood (50:37) - The Eagle and the Dragon: A Story of Strength and Reinvention (58:21) - Lex on business (1:04:52) - The Disciplines of Strength (1:09:33) - Powerlifting (1:22:37) - Role of strength in MMA, BJJ... and baseball (1:32:38) - What is Kabuki Strength? (1:38:55) - Equipment (1:50:09) - The importance of strong feet (1:59:15) - Chris's diet (2:05:37) - Lex on moderation in food (2:06:11) - Steroids and PED's (2:24:14) - Whiskey and deadlifts (2:33:03) - Is it better to work hard or smart? (2:41:52) - Advice for young people (2:45:02) - Fear of death

3 Aug 20212h 48min

Ishan Misra is a research scientist at FAIR working on self-supervised visual learning. Please support this podcast by checking out our sponsors: - Onnit: https://lexfridman.com/onnit to get up to 10% off - The Information: https://theinformation.com/lex to get 75% off first month - Grammarly: https://grammarly.com/lex to get 20% off premium - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil EPISODE LINKS: Ishan's twitter: https://twitter.com/imisra_ Ishan's website: https://imisra.github.io Ishan's FAIR page: https://ai.facebook.com/people/ishan-misra/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:49) - Self-supervised learning (16:24) - Self-supervised learning is the dark matter of intelligence (20:17) - Categorization (28:50) - Is computer vision still really hard? (32:35) - Understanding Language (42:14) - Harder to solve: vision or language (48:59) - Contrastive learning & energy-based models (52:59) - Data augmentation (57:19) - Fixed audio spike by lowering sound with pen tool (1:05:33) - Real data vs. augmented data (1:09:16) - Non-contrastive learning energy based self supervised learning methods (1:12:54) - Unsupervised learning (SwAV) (1:15:37) - Self-supervised Pretraining (SEER) (1:20:44) - Self-supervised learning (SSL) architectures (1:26:43) - VISSL pytorch-based SSL library (1:29:38) - Multi-modal (1:37:06) - Active learning (1:42:45) - Autonomous driving (1:54:12) - Limits of deep learning (1:58:19) - Difference between learning and reasoning (2:03:26) - Building super-human AI (2:11:14) - Most beautiful idea in self-supervised learning (2:15:02) - Simulation for training AI (2:18:27) - Video games replacing reality (2:19:40) - How to write a good research paper (2:24:08) - Best programming language for beginners (2:25:01) - PyTorch vs TensorFlow (2:28:26) - Advice for getting into machine learning (2:30:31) - Advice for young people (2:32:58) - Meaning of life

31 Juli 20210s