#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Zach Bitter is an ultramarathon runner and coach. Please support this podcast by checking out our sponsors: - Ladder: https://ladderlife.com/lex - Belcampo: https://belcampo.com/lex and use code LEX to get 20% off first order - Noom: https://trynoom.com/lex - BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Zach's Twitter: https://twitter.com/zbitter Zach's Instagram: https://www.instagram.com/zachbitter Zach's Website: https://zachbitter.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:34) - The marathon mentality (14:43) - The psychology of quitting (25:49) - Variety in ultramarathons (33:04) - What does it take to run 100 miles? (38:27) - Leading ultramarathon events (42:09) - Training and race strategy (44:39) - 100 Mile world record (48:41) - Foot strike variability and cadence (51:29) - The 11 hour barrier (54:57) - The most beautiful thing about running (1:01:19) - Zach's training regime (1:06:06) - MAF 180 Formula (1:16:31) - Training plans (1:31:30) - Marathons vs. 100 miles (1:40:31) - Zach's diet philosophy (1:55:19) - Fueling for race day (2:02:34) - Training while fasted (2:06:11) - Embracing the chaos (2:07:41) - 100-Mile treadmill WR (2:11:51) - The legend of Bert Kreischer (2:16:16) - The Transcontinental Run across America (2:33:51) - Who is the greatest endurance athlete of all time? (2:41:04) - Shoe technology in running (2:54:14) - Human limits (2:56:49) - Zach's biggest obstacles (3:00:34) - Advice for young people

29 Juli 20213h 6min

Cumrun Vafa is a theoretical physicist at Harvard. Please support this podcast by checking out our sponsors: - Headspace: https://headspace.com/lex to get free 1 month trial - The Jordan Harbinger Show: https://www.youtube.com/thejordanharbingershow - Squarespace: https://lexfridman.com/squarespace and use code LEX to get 10% off - Allform: https://allform.com/lex to get 20% off EPISODE LINKS: Cumrun's Twitter: https://twitter.com/cumrunv Cumrun's Website: https://www.cumrunvafa.org Puzzles to Unravel the Universe (book): https://amzn.to/3BFk5ms PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:08) - Difference between math and physics (09:51) - Evolution of quantum mechanics (13:09) - Can mathematics lead humanity off track (14:07) - Beauty in mathematics (19:27) - Philosophers using symmetry (25:20) - How can ancient geometry be used to understand reality (28:32) - Key ideas in the history of physics (31:26) - Einstein's special relativity (35:03) - Physicists building intuition (43:01) - Best work by Einstein (44:45) - Quantum mechanics (54:47) - Quantum gravity (57:02) - String theory (1:13:11) - 10th Dimension (1:19:48) - Skepticism regarding string theory (1:30:53) - Key figures in string theory (1:35:13) - String Theory's Nobel Prize (1:38:18) - Edward Witten (1:46:56) - String Theory Landscape & Swamplands (1:55:46) - Theories of everything (2:10:12) - Advice for young people (2:13:14) - Death

26 Juli 20212h 18min

Anya Fernald is the co-founder of Belcampo farms, chef, and regenerative agriculture expert. Please support this podcast by checking out our sponsors: - Gala Games: https://gala.games/lex - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off - Fundrise: https://fundrise.com/lex EPISODE LINKS: Anya's Instagram: https://www.instagram.com/anyafernald Belcampo's Instagram: https://www.instagram.com/belcampomeatco Belcampo's Website: https://belcampo.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:04) - Cooking is an art and a service (10:43) - Food is health (12:45) - Anticipation makes food taste better (14:36) - Lex on breaking the 72 hour fast (18:47) - Falling in love with cooking (20:28) - Alienation during the diet (23:09) - Cooking advice for minimalists (29:14) - Complexity of coconut oil (32:35) - Anya's favorite meal (39:17) - Sources of heat (41:46) - Why do people freak out about barbecue (44:58) - Does the origin of the meat itself make a difference? (47:06) - What is regenerative farming? (51:16) - AI will be a better farmer than humans (55:17) - Carbon negative farming is possible right now (57:04) - Certified Humane (1:00:34) - Evolutionary diet of animals (1:03:17) - Neuralink can help us understand animals (1:07:13) - All grass-fed meat made the same? (1:11:57) - Health benefits of grass-fed beef (1:16:29) - What does it take to be a woman CEO of a meat company? (1:23:57) - Making cheese for Italian mafia (1:27:56) - How to judge a good meal? (1:29:58) - The best meal in the world (1:37:48) - Anya played oboe in the Sicily municipal band (1:39:23) - Hunting has inspired regenerative farming (1:44:07) - Meaning of life (1:45:27) - Advice for young people: grow through discomfort

23 Juli 20211h 50min

Rick Doblin is a psychedelics researcher and the founder and executive director of the Multidisciplinary Association for Psychedelic Studies (MAPS). Please support this podcast by checking out our sponsors: - Theragun: https://therabody.com/lex to get 30 day trial - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Rick's Twitter: https://twitter.com/RickDoblin MAPS: https://maps.org PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:54) - Introduction to psychedelics (11:09) - Psychedelics reveals the inner depths of humans (23:43) - Differences between psychedelics (31:08) - The future of psychedelics (39:52) - Epigenetics (45:49) - DMT (53:16) - Ego dissolution (56:33) - One Flew Over The Cuckoo's Nest (59:32) - Psychedelics and Creativity (1:03:25) - MKUltra and the Grateful Dead (1:08:04) - Ted Kaczynski (1:13:46) - Timothy Leary (1:21:10) - Good Friday Experiment (1:25:46) - Forming of MAPS (1:37:01) - Gaining access to psychedelics (1:45:30) - MDMA Medical Trials (2:17:00) - Clinical Trials for other substances (2:21:43) - Future of society with psychedelics (2:26:13) - Big Pharma (2:32:32) - Advice for the younger generations (2:38:17) - Meaning of life

21 Juli 20212h 42min

Konstantin Batygin is a planetary astrophysicist at Caltech. Please support this podcast by checking out our sponsors: - Squarespace: https://lexfridman.com/squarespace and use code LEX to get 10% off - Literati: https://literati.com/lex - Onnit: https://lexfridman.com/onnit to get up to 10% off - National Instruments (NI): https://www.ni.com/perspectives EPISODE LINKS: Konstantin's Twitter https://twitter.com/kbatygin Konstantin's Website https://www.konstantinbatygin.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:17) - Overview of our Solar System (22:14) - What is the Oort Cloud? (27:10) - Life in the interstellar medium (28:42) - Are there aliens out there? (31:22) - How unique is Earth? (34:02) - Did Jupiter destroy early planets? (40:16) - How hard is it to simulate the Universe? (44:49) - Quantum mechanics in evolution of objects in the Solar system (49:15) - Simulating the first formations around the Sun (55:02) - Will it be possible to simulate the full history of the Solar System? (57:23) - How far should we go with the simulation? (59:43) - Increasing immersion in video games (1:06:09) - What is Planet Nine? (1:12:37) - The origin of life (1:15:02) - Evidence of Planet Nine (1:17:32) - Discovery of Neptune (1:18:42) - When will we find Planet Nine? (1:21:21) - Planet Nine throws rocks into the Kuiper Belt (1:25:15) - Could Planet Nine be a primordial black hole? (1:35:20) - Commercial space revolution boosts science and the human condition (1:42:46) - Solving sex in space (1:43:24) - Would humans evolve if we couldn't see the stars? (1:49:08) - Military funding and science (1:53:11) - Is Oumuamua space junk from a distant alien civilization? (2:06:33) - Wild ideas create the future (2:14:22) - The perfect place to die (2:16:03) - Greatest song of all time (2:22:34) - Music enables science for Konstantin (2:24:51) - Music practice tips for busy people (2:28:41) - Memories of 1990s Russia (2:35:14) - Advice for young people (2:41:10) - Meaning of life

19 Juli 20212h 45min

Michael Malice is a political thinker, podcaster, and author. Please support this podcast by checking out our sponsors: - Gala Games: https://gala.games/lex - Indeed: https://indeed.com/lex to get $75 credit - BetterHelp: https://betterhelp.com/lex to get 10% off - MasterClass: https://masterclass.com/lex to get 15% off EPISODE LINKS: Michael's Twitter: https://twitter.com/michaelmalice Michael's Community: https://malice.locals.com/ Michael's YouTube: https://www.youtube.com/channel/UC5tj5QCpJKIl-KIa4Gib5Xw Michael's Website: http://michaelmalice.com/about/ Your Welcome podcast: https://bit.ly/30q8oz1 The Anarchist Handbook (book): https://amzn.to/3yUb2f0 The New Right (book): https://amzn.to/34gxLo3 Dear Reader (book): https://amzn.to/2HPPlHS Podcast (Round 1): https://www.youtube.com/watch?v=BIk1zUy8ehU PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:00) - Animal Farm (11:02) - Emma Goldman (14:07) - Albert Camus (15:37) - How to be a hero in Nazi Germany (22:43) - Camus on Existentialism vs Nihilism (28:44) - Cynicism is a lie (33:52) - Nazi invasion of the Soviet Union (54:10) - Lex and Michael argue: can most people think on their own? (1:05:48) - How Lex and Michael use Twitter (1:15:11) - Life is beautiful (1:18:13) - Returning to Ukraine (1:20:07) - Michael is now an underwear model (1:24:13) - The Anarchist Handbook (1:25:59) - Tolstoy was an anarchist (1:38:41) - Anarchy debate between Lex and Michael (2:07:49) - Why Michael doesn't vote (2:25:04) - Austin and New York (2:33:40) - Alex Jones

15 Juli 20212h 44min

Roger Reaves is one of the most prolific drug smugglers in history. Please support this podcast by checking out our sponsors: - Noom: https://trynoom.com/lex - Allform: https://allform.com/lex to get 20% off - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Smuggler (book): https://amzn.to/3xydszD PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:56) - Money (12:17) - Pablo Escobar (19:30) - Jorge Ochoa (27:05) - First time (31:51) - Landing an airplane on the highway (34:41) - Barry Seal (45:05) - Mena, Arkansas (49:58) - Assassination of Barry Seal (1:03:10) - American Made (1:07:22) - Blow (1:09:28) - Story of torture in a Mexican prison (1:14:08) - Getting shot down (1:27:51) - Prison (1:41:34) - Reflections on a life of crime (1:46:51) - Advice for young people (1:49:49) - Love (2:03:09) - Death (2:05:55) - Meaning of life (2:09:58) - Poem

11 Juli 20212h 15min

Sara Walker is an astrobiologist and theoretical physicist interested in the origin of life. Please support this podcast by checking out our sponsors: - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - NetSuite: http://netsuite.com/lex to get free product tour - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off EPISODE LINKS: Sara's Twitter: https://twitter.com/Sara_Imari Sara's Website: http://emergence.asu.edu/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:44) - Origin of life (15:38) - Did aliens seed life on Earth? (20:48) - What is life? (32:27) - Cellular automata (36:56) - The laws of physics may change with time (46:41) - Nobel Prize for the origin of life (52:01) - Is consciousness fundamental to the universe? (1:03:19) - Life is the most deterministic part of physics (1:05:54) - Free will (1:14:11) - How to detect alien life (1:28:48) - How many alien civilization are out there? (1:35:32) - Shadow biosphere (1:41:59) - UFO sightings (1:45:35) - Exponential population growth of AI lifeforms (1:52:42) - The role of death in life (1:56:45) - Advice for young people (2:02:31) - Meaning of life

9 Juli 20212h 5min