The Aliquot Preview25 Feb 2021

PREVIEW Aliquot #18: The dual nature of IGF-1: Striking a balance for optimal health

Insulin-like growth factor-1, or IGF-1 for short, is a protein that plays critical roles in major growth pathways in the human body. It influences nearly every tissue in the body, especially developmental growth, skeletal muscle and neurons. Emerging evidence suggests that IGF-1 also regulates the aging process. Overactivity of IGF-1 has been implicated in aging and age-related diseases, such as cancer. Balancing the beneficial and (sometimes) harmful effects of IGF-1 via exercise and fasting is critical to maintaining health.

In this episode, we discuss:

(00:00) Introduction
(03:23) The role of both mTOR and the IGF-1 pathway in cellular growth and their regulation by amino acids (Peter Attia discussion)
(11:50) Living longer as a function of preventing insidious damage to our cells and tissues
(14:53) Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans (Valter Longo discussion)
(17:10) Effects of IGF-1 on human lifespan
(23:01) Refeeding that follows fasting mimicking creates an environment that may be just right for the regeneration of healthy cells
(25:55) The growth-longevity trade-off (Rhonda Patrick & Mike Maser discussion)

You can see the original full interview with Dr. Attia You can see the original full interview with Dr. Longo You can hear the original full interview with Dr. Rhonda Patrick and Mike Maser Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more. Learn more and sign up at: www.foundmyfitness.com/crowdsponsor

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Avsnitt(25)

PREVIEW Aliquot #106: The Science of Longevity Vitamins: Taurine, Ergothioneine, and PQQ

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30 Apr 202435min

PREVIEW Aliquot #92: The Underestimated Role of Resistance in Body Recomposition

Having a healthy body composition, with plenty of lean mass – in the form of muscle and bones – is essential for health throughout the lifespan. Achieving a healthy body composition requires a balance...

11 Aug 202336min

PREVIEW Aliquot #85: The Science of Wrinkle Prevention ⎯ Building Resilient Skin

Your skin is a crucial barrier to the outside world – the first line of defense against environmental exposures, and the primary means by which the body retains fluids necessary for survival. Conseque...

18 Apr 202325min

PREVIEW Aliquot #78: The minimum effective dose for hypertrophy

Incorporating resistance training into your exercise regimen presents a scheduling dilemma – there's simply not enough time. Performing time-efficient workouts that involve supersets, paired sets, dro...

14 Jan 202320min

PREVIEW Aliquot #70: Preventing age-related muscle loss

The progressive loss of skeletal muscle mass and strength that occurs with aging, referred to as sarcopenia, begins as early as our 30s or 40s. Many factors contribute to sarcopenia, including diet an...

22 Okt 202232min

PREVIEW Aliquot #65: Concerns with chronic NSAID use

Non-steroidal anti-inflammatory drugs, or NSAIDs, are among the most widely used drugs worldwide, available in both prescription and over-the-counter forms, such as aspirin, ibuprofen, naproxen, and o...

31 Aug 202226min

PREVIEW Aliquot #61: How dietary fiber influences metabolic health

Dietary fiber is a broad term that refers to the non-digestible components of fruits and vegetables. Gut microbes break down certain types of fiber, releasing micronutrients trapped in the fiber matri...

19 Juli 202232min

PREVIEW Aliquot #59: How alcohol affects sleep, behavior, and cancer risk

Alcohol, one of the most used drugs worldwide, is a controversial subject. Whereas some research suggests drinking alcohol improves health, an abundance of evidence indicates that drinking alcohol als...

20 Juni 202232min