33. Over-Methylation Explained: COMT, Estrogen, Mood & Inflammation

33. Over-Methylation Explained: COMT, Estrogen, Mood & Inflammation

In this episode of the Histamine Well Podcast, Joanne Kennedy explains why over-methylation is becoming increasingly common, especially among women, and how it’s closely linked to COMT enzyme activity, estrogen dominance, mood disorders, and inflammation. This episode breaks down the biochemistry of methylation in a clear, practical way—exploring how estrogen affects COMT, why some people react badly to methylated B vitamins, and how over-methylation can drive symptoms such as anxiety, irrita...

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Avsnitt(83)

Practical Tips to Lower Histamine Levels Fast [Replay]

Practical Tips to Lower Histamine Levels Fast [Replay]

Does your histamine bucket feel like it’s overflowing? In this replay of one of the Histamine Well Podcast’s fourth most popular episodes, Joanne explores her approach to managing histamine symptoms w...

2 Nov 20min

Q&A. When Should I Take L-Theanine?

Q&A. When Should I Take L-Theanine?

When is the best time to take L-theanine—for daytime anxiety, before bed, or when you wake during the night? In this short Q&A episode of The Histamine Well Podcast, Joanne discusses how she uses L-th...

14 Okt 2min

61. SIBO Case Study: Bloating, Constipation, IBS & Histamine

61. SIBO Case Study: Bloating, Constipation, IBS & Histamine

Bloating, constipation, and food reactions after food poisoning—could SIBO be part of the picture? In this episode of The Histamine Well Podcast, Joanne walks through a real patient case of small inte...

12 Okt 11min

Q&A. Why Do I Feel Depressed On Calcium-D-Glucarate?

Q&A. Why Do I Feel Depressed On Calcium-D-Glucarate?

Have you noticed low mood or sadness after taking calcium D-glucarate? If you’re using it to support oestrogen detoxification or address high beta-glucuronidase on a gut test, your stage of life and h...

7 Okt 3min

60. The Gut and Immune System: The Histamine Connection

60. The Gut and Immune System: The Histamine Connection

Could your gut help explain why you’re reacting to foods you once tolerated? In this episode of The Histamine Well, Joanne explores the connection between gut health and histamine intolerance, explain...

5 Okt 25min

Q&A. Why Do I Feel More Bloated on a Low FODMAP Diet?

Q&A. Why Do I Feel More Bloated on a Low FODMAP Diet?

A low FODMAP diet is often used to reduce bloating, so why might your symptoms get worse after starting one? In this short Q&A episode, Joanne explores three possibilities: eating more sulfur-rich foo...

30 Sep 3min

59. Circadian Rhythm: How Your Body Clock Affects Sleep, Hormones, Gut Health & Histamine

59. Circadian Rhythm: How Your Body Clock Affects Sleep, Hormones, Gut Health & Histamine

In this episode of The Histamine Well, Joanne is joined by clinical nutritionist Melanie Peers to explore circadian rhythm: the daily cycle that helps coordinate sleep, energy, hormones, digestion and...

28 Sep 36min

Q&A. Why Do I Feel Sick from Taking  N-Acetylcysteine?

Q&A. Why Do I Feel Sick from Taking N-Acetylcysteine?

NAC can support glutathione production, respiratory health and biofilm disruption—but some people experience nausea, headaches, brain fog, fatigue or bloating after taking it. In this Q&A episode, Jo...

23 Sep 5min

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