Season 2 Episode 1 BCL-2 Inhibitors: Driving Cells to Destruction
Unraveled1 Feb 2023

Season 2 Episode 1 BCL-2 Inhibitors: Driving Cells to Destruction

The story begins decades ago with a man named Stanley Korsmeyer, who led the molecular oncology program at Dana-Farber from 1998 until his death in 2005. He discovered that B-cell cancers like CLL over-produced a protein called BCL-2, and interfered with apoptosis, or programmed cell death. But how that went from an interesting discovery to a game-changing cancer drug is a story of persistence and momentum, and it’s the first episode of season two of Unraveled

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Avsnitt(14)

Season 2 Episode 6: Big Data, AI, and Cancer Research

Season 2 Episode 6: Big Data, AI, and Cancer Research

As our universe of knowledge expands, sometimes incrementally and more often, exponentially, its new dimensions create new challenges. The more we know, the better our tools are, the more choices we h...

17 Maj 202328min

Season 2 Episode 5: With a Little Help From My Friends: Combination Immunotherapy

Season 2 Episode 5: With a Little Help From My Friends: Combination Immunotherapy

If there is such a thing as a holy grail in cancer research, a secret spell or golden ring that can ward off any and all forms of the disease, it probably lives somewhere in the realm of immunotherapy...

26 Apr 202332min

Season 2 Episode 4: Making it Personal: Targeted Cancer Therapies

Season 2 Episode 4: Making it Personal: Targeted Cancer Therapies

By the early 2000s, researchers at Dana-Farber and elsewhere knew that a certain protein appeared in many tumors taken from lung cancer patients. Based on that data, doctors started treating those pat...

5 Apr 202330min

Season 2 Episode 3: Stop the Division: CDK-4/6 Inhibitors and the Cell Cycle

Season 2 Episode 3: Stop the Division: CDK-4/6 Inhibitors and the Cell Cycle

Cancer is often a problem of cell division; cancer cells keep doubling and doubling, faster and faster. Eventually, they crowd out the healthy cells we need to survive. So researchers proposed a quest...

15 Mars 202326min

Season 2 Episode 2: Thalidomide and its Second Act in Multiple Myeloma

Season 2 Episode 2: Thalidomide and its Second Act in Multiple Myeloma

Momentum isn't always one way. And it's not always constant. Sometimes it shoves you sideways, sometimes it stops you in your tracks. And sometimes only sometimes, it drives you to write one of the mo...

22 Feb 202328min

Season 2 Trailer

Season 2 Trailer

In season 2 of Unraveled, we explore the theme of momentum. The momentum that takes therapies from test bench to bedside, and then back to test bench for fine tuning. The momentum provided by research...

27 Jan 20232min

Episode 6: Dana-Farber in the Time of COVID

Episode 6: Dana-Farber in the Time of COVID

A beauty… that in some cases becomes tragic. It’s not the way most people would describe a virus. In the simplest of terms, a virus is a snippet of genetic code. It can’t reproduce on its own. So, in ...

4 Okt 202131min

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