Season 3 Episode 1: Advances in Endometrial Cancer Research

Cigall Kadoch had a hunch that the research in her lab might be relevant to endometrial cancer research. She had spent more than a decade studying the molecular machinery that unwinds DNA in the nucleus of a cell to make the right DNA instructions readable by the cell at the right time. This machinery – the SWI/SNF or BAF complex – is altered by gene mutations in about 20 percent of cancers, including an aggressive form of endometrial cancer. The discovery of that connection, and the collaborative translational research done with gynecologic oncologist Jessica St. Laurent, MD, at Dana-Farber to determine if an inhibitor targeting these complexes could benefit patients with endometrial cancer — it’s the story we’re sharing in this episode of Unraveled Presents: Conversations About Cancer. Episode Notes: The Nature Genetics paper detailing Kadoch's and St. Laurent's findings: https://www.nature.com/articles/s41588-025-02333-9 The Dana-Farber story: https://blog.dana-farber.org/insight/2025/10/dana-farber-research-uncovers-potential-targeted-therapy-for-endometrial-cancer/ Clarification of facts and sources: Colorectal and uterine cancer are, respectively, the third and fourth most common cancers in women as of 2026, each affecting 7% of women: https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2026/2026-cancer-facts-and-figures.pdf

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Avsnitt(15)

Season 2 Episode 6: Big Data, AI, and Cancer Research

As our universe of knowledge expands, sometimes incrementally and more often, exponentially, its new dimensions create new challenges. The more we know, the better our tools are, the more choices we h...

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26 Apr 202332min

Season 2 Episode 4: Making it Personal: Targeted Cancer Therapies

By the early 2000s, researchers at Dana-Farber and elsewhere knew that a certain protein appeared in many tumors taken from lung cancer patients. Based on that data, doctors started treating those pat...

5 Apr 202330min

Season 2 Episode 3: Stop the Division: CDK-4/6 Inhibitors and the Cell Cycle

Cancer is often a problem of cell division; cancer cells keep doubling and doubling, faster and faster. Eventually, they crowd out the healthy cells we need to survive. So researchers proposed a quest...

15 Mars 202326min

Season 2 Episode 2: Thalidomide and its Second Act in Multiple Myeloma

Momentum isn't always one way. And it's not always constant. Sometimes it shoves you sideways, sometimes it stops you in your tracks. And sometimes only sometimes, it drives you to write one of the mo...

22 Feb 202328min

Season 2 Episode 1 BCL-2 Inhibitors: Driving Cells to Destruction

The story begins decades ago with a man named Stanley Korsmeyer, who led the molecular oncology program at Dana-Farber from 1998 until his death in 2005. He discovered that B-cell cancers like CLL ove...

1 Feb 202330min

Season 2 Trailer

In season 2 of Unraveled, we explore the theme of momentum. The momentum that takes therapies from test bench to bedside, and then back to test bench for fine tuning. The momentum provided by research...

27 Jan 20232min