Biohacking Beauty: The Anti-Aging Skincare Podcast22 Apr

Why Niacinamide Is Not the NAD+ Hero You Think It Is

Most of the NAD+ skincare on shelves right now is built on a misunderstanding. And if you've been trusting niacinamide to do the heavy lifting, this episode is going to change how you read a label.

This episode is Part 2 of our NAD+ deep dive. Here, we get into what actually works to raise NAD+ in the skin, the real precursors, the delivery technology that gets them where they need to go, and the mitochondrial support system most brands leave out. We also walk through the lifestyle levers that move the needle, and why one of them becomes non-negotiable for women after a certain age.

If Part 1 explains what steals your NAD+, this episode is where the science gets practical and eye-opening.

What's Discussed:

(5:07) What the clinical data actually says about topical niacinamide
(7:21) Why most niacinamide products on your shelf are underdosed
(8:16) The roundabout pathway that makes niacinamide a poor NAD+ precursor
(9:03) Niacinamide is a brightening agent, not an NAD+ booster
(10:15) Why NMN can't cross the skin barrier alone
(11:19) CD38 and blocking the enzyme that destroys NAD+
(13:03) NAD+ alone is potential energy, not usable energy
(13:45) Liposomal encapsulation and how real precursors get into the skin
(17:02) The five mitochondrial pathways your skin actually needs
(18:53) Senescent cells and the next telomeres conversation
(25:17) Why NAD Apex targets NAD+ in three dimensions
(26:39) Lifestyle strategies: fasting and the AMPK pathway
(28:47) How to get 30 to 50% more NAD+ from caloric restriction through fasting
(30:37) The fun fact behind why 16:8 fasting became the standard
(33:02) HIIT and its compounding effect on baseline NAD+
(34:51) Sleep is an NAD+ dependent repair session, not just rest
(39:15) Your skin does 8x more renewal at night
(41:38) Sun protection as an NAD+ strategy
(44:49) Why you should expose your back more than your face
(45:29) Contrast therapy, heat shock proteins, and cold-driven biogenesis
(50:32) Why stacking NAD+ boosting activities at 50% beats maxing out one modality
(52:49) The perimenopause problem no one is talking about
(56:29) Why niacinamide creates homework for the body
(1:01:46) You recycle more NAD+ daily than you can ever supplement
(1:02:19) 5-Amino-1MQ, the peptide that recycles NAD+
(1:05:35) Mitophagy, autophagy, and the role of spermidine
(1:06:44) Ergothioneine, the only antioxidant with a direct mitochondrial transporter
(1:07:46) Fermented resveratrol and activating SIRT1

Check out resources mentioned:

Part 1 of our NAD+ deep dive: The NAD+ Thief Your Skin Can't Escape: CD38, Zombie Cells, and the Decline

Check out our NAD+ Guide: NAD+ & SKIN AGING - The Cellular Energy Connection

Sleep is Skincare episode: How Timing Unlocks Your Body’s Best Skincare Repair

Find more from Young Goose:

Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at https://younggoose.com
Instagram: @young_goose_skincare
Vampire Exosomes: Professional Exosome Serum for Regeneration and Post-Treatment Recovery https://younggoose.com/products/vampire-exosomes

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