HOT TOPICS: Milrinone and Cerebral Perfusion After Aneurysmal Subarachnoid Hemorrhage

In this episode of the NCS Podcast Hot Topics series, host Rich Choi, MD, is joined by Chiara Robba, MD, PhD, to discuss the article "The Effects of Milrinone Systemic Administration on Cerebral Perfusion as Measured with Computed Tomography in Aneurysmal Subarachnoid Hemorrhage Patients," published in Neurocritical Care.

Their conversation explores the complex, multifactorial pathophysiology of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage and the potential role of intravenous milrinone as a rescue therapy. They discuss how milrinone may influence both systemic and cerebral hemodynamics, as well as the role of CT perfusion imaging in evaluating cerebral blood flow and perfusion heterogeneity.

They also review findings from the retrospective study, including milrinone's association with increased cardiac index but not a consistent increase in cerebral blood flow. Among patients who did not develop delayed cerebral ischemia, cerebral perfusion became more spatially homogeneous as the milrinone dose increased. Dr. Robba explains why the distribution of cerebral blood flow may be more informative than its average value, the potential of perfusion heterogeneity as a marker of treatment response and why larger prospective studies are needed before these findings can inform changes in clinical practice.

The views expressed on the NCS Podcast are solely those of the hosts and guests and do not necessarily reflect the opinions or official positions of the Neurocritical Care Society.

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CURRENTS: Breaking Barriers: How Brazil's RESILIENT Trials Redefined Stroke Research in Latin America

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29 Juli 26min

CURRENTS: Neurocritical Care Disorders of Consciousness: Do We Have the Education We Need to Provide Care?

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22 Juli 37min

$HOT TOPICS: Surgical Interventions for Super-Refractory Status Epilepticus$

HOT TOPICS: Surgical Interventions for Super-Refractory Status Epilepticus

In this episode of the NCS Podcast Hot Topics series, host Rich Choi, MD, is joined by Eric Rosenthal, MD, to discuss the article "Surgical Intervention for Super-Refractory Status Epilepticus," a sys...

15 Juli 38min

HOT TOPICS: Neuroprognostication in Acute Ischemic Stroke

In this episode of the NCS Podcast Hot Topics series, host Rich Choi, MD, is joined by Alejandro Rabinstein, MD, Shraddha Mainali, MD, and Krishna Rajajee, MD, to discuss the article "Guidelines for N...

8 Juli 41min

PERSPECTIVES: Moving Evidence Into Practice With Molly McNett

In this episode of the NCS Podcast Perspectives series, host Nicholas Morris, MD, and co-host Tom Lawson, PhD, ACNP-BC, FNCS, speak with Molly McNett, PhD, RN, CNRN, FNCS, FAAN, about her career in ne...

1 Juli 45min

CURRENTS: Story of Hope — Vanessa Abraham's Journey of Recovery

In this episode of the NCS Podcast Currents series, host Lauren Koffman, DO, MS, speaks with Vanessa Abraham, MS, CCC-SLP, and Jared Rosen, MD, about Vanessa's Story of Hope and the lasting connectio...

24 Juni 29min

MASTERCLASS: Managing Respiratory Infections in the ICU

In this episode of the Neurocritical Care Society Podcast Masterclass series, hosts Stephan Mayer, MD, FCCM, FNCS, and Jon Rosenberg, MD, are joined by Richard Wunderink, MD, professor of medicine at ...

17 Juni 33min