298. The Neuroscience of Antidepressants Part 2: The Glutamate Hypothesis

298. The Neuroscience of Antidepressants Part 2: The Glutamate Hypothesis

In part 2 of my Neuroscience episodes about antidepressants I’m diving into the Glutamate Hypothesis. I chat about the role of the glutamatergic system within the brain in helping us to better understand why some people don’t respond well to the first line of treatments, such as SSRIs. I’m also diving into treatment resistant depression, electro convulsive therapy (ECT) neuroplasticity and transcranial magnetic stimulation. LINKS: Listen to Part 1 of this series The Neuroscience of Anti-Depressants: The Monoamine Hypothesis at https://pod.fo/e/21783a . Read the paper ‘Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization’ accessible via PUBMED https://tr.ee/glutamatergic-paper . Listen to episode 50. Stress on the brain and how to reverse its effects at https://pod.fo/e/1f8306 . Listen to episode 257 my episode on Ketamine as a treatment for depression here https://bit.ly/Dyfm-ketamine. Join the DYFM Facebook Group https://bit.ly/dyfm-group . Follow @dyfmpodcast on IG Follow @alexispredez on IG Follow @listnrentertainment on IG CREDITS Host: Alexis Fernandez Executive Producer & Editor: Elise CooperDigital Producer: Zoe Panaretos DYFM Social Producer: Shania MaguaManaging Producer: Sam Cavanagh Find more great podcasts like this at www.listnr.com/ See omnystudio.com/listener for privacy information. Learn more about your ad choices. Visit megaphone.fm/adchoices

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The Reset You Actually Need - Day 7. More self trust - stop negotiating with your own excuses

The Reset You Actually Need - Day 7. More self trust - stop negotiating with your own excuses

Self-trust doesn’t disappear because you fail. It erodes because you keep negotiating with yourself and breaking the deal. In Day 7 of The Reset You Actually Need, we talk about why so many people s...

19 Jan 23min

The Reset You Actually Need - Day 6. How to stop feeling disappointed and regain control over your life

The Reset You Actually Need - Day 6. How to stop feeling disappointed and regain control over your life

The Reset You Actually Need Feeling constantly disappointed in people, in situations, or in yourself is exhausting. In this episode of The Reset You Actually Need, we unpack why disappointment is ra...

18 Jan 24min

The Reset You Actually Need - Day 5. Stop waiting to feel ready: Why action changes identity

The Reset You Actually Need - Day 5. Stop waiting to feel ready: Why action changes identity

Episode 5 – Stop Waiting to Feel Ready: Why Action Changes Identity The Reset You Actually Need – Day 5 So many people believe confidence, clarity, or motivation comes before they act. In Day 5 of ...

15 Jan 23min

The Reset You Actually Need - Day 4. Discipline the body and the mind will follow

The Reset You Actually Need - Day 4. Discipline the body and the mind will follow

The Reset You Actually Need – Day 4 We’re often told to fix our mindset first, to think more positively, feel more motivated, or “get our head right.” In Day 4 of The Reset You Actually Need, we fli...

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The Reset You Actually Need - Day 3. The personality traits you are romanticising that are ruining your progress

The Reset You Actually Need - Day 3. The personality traits you are romanticising that are ruining your progress

The Reset You Actually Need – Day 3 So many people believe their struggles are just “part of who they are.” In Day 3 of The Reset You Actually Need, we unpack the personality traits people often rom...

13 Jan 24min

The Reset You Actually Need - Day 2. You Don't Need a New Life, You Need New Standards

The Reset You Actually Need - Day 2. You Don't Need a New Life, You Need New Standards

The Reset You Actually Need – Day 2 Feeling like you need to change everything to finally feel better? In Day 2 of The Reset You Actually Need, we explore why most people don’t actually need a drama...

12 Jan 25min

The Reset You Actually Need - Day 1. How to stop feeling stuck by changing your state

The Reset You Actually Need - Day 1. How to stop feeling stuck by changing your state

Bonjour 2026! Its that time again where we hit the ground running with a January mini series. For the next 10 days (week days that is) I will be releasing a slightly shorter episode daily to get y...

11 Jan 27min

466. Incredible sulk, Do I leap into a new life or am i just escaping? Toxic comments and unwavering opinions  (Headnoise)

466. Incredible sulk, Do I leap into a new life or am i just escaping? Toxic comments and unwavering opinions (Headnoise)

In this episode, I answer your voicemail questions! If you would like to send in a question email please email: ⁠⁠⁠⁠⁠⁠⁠⁠⁠info@dyfmpod.com⁠⁠⁠⁠⁠⁠⁠⁠⁠ or if you would like to send in a Voice Message go to...

6 Jan 33min

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