Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Avsnitt(1361)

Quad Injection | Why You Should NEVER Inject Your Quads

Quad Injection | Why You Should NEVER Inject Your Quads

Never do a quad injection. There are other shot locations that are far better and I'm going to elaborate on why in this article. When you first get into this stuff and you're trying to learn about proper administration technique the main shot locations you'll see recommended are glutes, quads, and maybe delts.… Learn more about your ad choices. Visit megaphone.fm/adchoices

10 Nov 20195min

Can MK-677 Cause Brain Damage? | The Effects Of Chronic Ghrelin Exposure

Can MK-677 Cause Brain Damage? | The Effects Of Chronic Ghrelin Exposure

It is theorized in the community that MK-677 can cause brain damage via chronically elevating ghrelin levels in the body. Does this crossover to human use, and has it been observed to date? Well, there have in fact been links established between chronic ghrelin exposure and negative mental outcomes.… Learn more about your ad choices. Visit megaphone.fm/adchoices

9 Nov 201910min

Does Lactobacillus Reuteri ATCC PTA 6475 Probiotic Help Prevent Hair Loss? | My Review

Does Lactobacillus Reuteri ATCC PTA 6475 Probiotic Help Prevent Hair Loss? | My Review

Lactobacillus Reuteri ATCC PTA 6475 is a strain that was hyped up in the community after an article was published called “Probiotic ‘glow of health': it's more than skin deep” [R]. In the article, you can see that the mice that were fed with this probiotic strain experienced significantly better hair growth, and also exhibited a much more favorable ratio of anagen to telogen hair cycle stages.… Learn more about your ad choices. Visit megaphone.fm/adchoices

8 Nov 20193min

Oral Castor Oil For Hair Loss Review – My Experience And Others

Oral Castor Oil For Hair Loss Review – My Experience And Others

After I made my first oral castor oil for hair loss post a couple of months ago, I received hundreds of DM's, private messages, YouTube comments, emails and tweets asking me to post an update. Well, here it is. After trying oral castor oil for hair loss for 2 months, I have concluded that it is an effective growth promoter, and is far more potent than topical castor oil.… Learn more about your ad choices. Visit megaphone.fm/adchoices

8 Nov 201915min

Example Of A Perfect Nose To Tail Carnivore Diet

Example Of A Perfect Nose To Tail Carnivore Diet

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31 Okt 201910min

Gorilla Mode Pre-Workout Review | Comprehensive Supplement Breakdown

Gorilla Mode Pre-Workout Review | Comprehensive Supplement Breakdown

Gorilla Mode Pre-Workout is the most potent and comprehensive pre-workout on the market in ALL aspects. Pump, strength, endurance, cognitive enhancement, and overall performance. Gorilla Mode Supplement Facts Per Full Daily Dose: L-Citrulline – 9000 mg Creatine Monohydrate – 5000 mg GlycerPump (65% Glycerol Powder) – 3000 mg Betaine Anhydrous – 2500 mg L-Tyrosine – 1500 mg Agmatine Sulfate – 1000 mg Kanna (Sceletium tortuosum) – 500 mg Caffeine Anhydrous – 350 mg N-Phenethyl Dimethylamine Citrate – 350 mg BioPerine® (Black Pepper Fruit Extract) (standardized to 95% Piperine) – 10 mg Huperzine A – 400 mcg Gorilla Mode Vs. … Learn more about your ad choices. Visit megaphone.fm/adchoices

30 Okt 20191h 2min

How To Build Capped 3D Delts | Practical Tips To Develop Death Star Delts

How To Build Capped 3D Delts | Practical Tips To Develop Death Star Delts

Despite the fact that muscle bellies will mostly determine what shape your shoulders (or any muscle group) take on as they get bigger, there are some things you can do to maximize your genetics and encourage the development of capped 3D delts.… Learn more about your ad choices. Visit megaphone.fm/adchoices

24 Okt 20197min

Why Your Hair Loss Prevention Topicals Might Not Be Working | Scalp Caked With Sebum

Why Your Hair Loss Prevention Topicals Might Not Be Working | Scalp Caked With Sebum

122 Learn more about your ad choices. Visit megaphone.fm/adchoices

21 Okt 20193min

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