Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Avsnitt(1361)

Deviated Septum Or Inflamed Turbinates The Cause Of Mouth Breathing? | ENT Doctor’s Opinion On Mewing

Deviated Septum Or Inflamed Turbinates The Cause Of Mouth Breathing? | ENT Doctor’s Opinion On Mewing

Following up on my previous post where I talked about my deviated septum, this topic extends by finding an answer to the cause of my mouth breathing. During my last meeting with my ear nose and throat doctor I asked if the main cause of my mouth breathing was my deviated septum, or the inflammation of my turbinates.… Learn more about your ad choices. Visit megaphone.fm/adchoices

22 Sep 20192min

Can a Chiropractor Fix a Deviated Septum? | ENT Doctor’s Opinion

Can a Chiropractor Fix a Deviated Septum? | ENT Doctor’s Opinion

Can a Chiropractor fix a deviated septum? Some of my followers told me not to get deviated septum surgery and to seek out a Chiropractor instead. Supposedly, they can just snap your nose back into place, and you can avert having to go through surgery entirely.… Learn more about your ad choices. Visit megaphone.fm/adchoices

22 Sep 201942s

Half The Female Population Uses A Nandrolone Analog For Birth Control | Deca Only Cycle

Half The Female Population Uses A Nandrolone Analog For Birth Control | Deca Only Cycle

A rabbit hole I've been going down over the past few months is the Deca only cycle, synthetic progestins, and Nandrolone analogs. Something right in front of our faces is the fact that women are being prescribed a Nandrolone analog for contraception.… Learn more about your ad choices. Visit megaphone.fm/adchoices

20 Sep 201914min

How Many Days Per Week I Workout To Maintain My Physique

How Many Days Per Week I Workout To Maintain My Physique

I used to be religious about hitting 5-6 workouts per week to maintain my physique. This was at a time when I was hardcore into bodybuilding and assumed that any less than that would cause my physique to whither away. This was also the same time that I assumed that I needed 200 mg per week of Testosterone for my TRT or else I would lose everything I had gained over the years.… Learn more about your ad choices. Visit megaphone.fm/adchoices

19 Sep 20194min

Oral Castor Oil for Hair Loss Prevention?

Oral Castor Oil for Hair Loss Prevention?

Oral castor oil is something not thoroughly explored in the hair loss community, despite a significant amount of promising data backing its potential efficacy. Typically, castor oil is topically applied. In practical application, its effect on hair loss prevention topically seems to be minimal when it comes to dealing with androgenic alopecia as opposed to a skin condition.… Learn more about your ad choices. Visit megaphone.fm/adchoices

19 Sep 201915min

My IGF-1 Level On 3 IU Of Pharma Grade GH

My IGF-1 Level On 3 IU Of Pharma Grade GH

Many bodybuilders seeking hyperplasia and enhanced lipolysis use GH (HGH/human growth hormone). Even individuals just seeking anti-aging benefits have started to incorporate GH into their hormone replacement therapy protocols. Most of these individuals have no idea what their IGF-1 levels actually are as a result of the amount of GH they are using.… Learn more about your ad choices. Visit megaphone.fm/adchoices

17 Sep 20192min

Are SARMs Actually Side Effect Free? Or Are They Just As Bad As Steroids?

Are SARMs Actually Side Effect Free? Or Are They Just As Bad As Steroids?

Are SARMs side effect free? Also known as the Selective Androgen Receptor Modulators, SARMs are tissue selective anabolic agents designed with the intention of replicating the anabolic effects of steroids in muscle tissue and bone without the androgenicity in other affected tissues.… Learn more about your ad choices. Visit megaphone.fm/adchoices

16 Sep 20198min

The Highest Steroid Dosages Used By 7 Top IFBB Pros In The 90s

The Highest Steroid Dosages Used By 7 Top IFBB Pros In The 90s

Something every aspiring bodybuilder wants to know is what drugs and dosages the top IFBB pros at the Olympia are using. This article is going to quickly break down the biggest steroid cycles used by 7 top tier IFBB pros in the 90s.… Learn more about your ad choices. Visit megaphone.fm/adchoices

6 Sep 201910min

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