Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Avsnitt(1361)

Does Cardarine Cause Cancer? | The Human Equivalent Dose

Does Cardarine Cause Cancer? | The Human Equivalent Dose

This is something I skimmed over in my initial article on Cardarine. I wanted write a dedicated article on this topic as I believe the human equivalent Cardarine dose that caused cancer growth is often calculated incorrectly. Many people think the dosage is some exorbitant amount and they use that to justify their use thinking the human equivalent dosage that caused cancer in rats was thousands of milligrams, when in reality, it really wasn't.… Learn more about your ad choices. Visit megaphone.fm/adchoices

13 Aug 20196min

Reacting To And Analyzing Aaron Baker’s Steroid Cycle In The 90’s

Reacting To And Analyzing Aaron Baker’s Steroid Cycle In The 90’s

This interview discussing Aaron Baker's steroid cycle was recorded by Tom Platz in the 90's. Granted, this is supposed to be an anonymous interview. This is just an educated guess based on mannerisms and what they sound like and look like, so by no means take it as a definitive statement.… Learn more about your ad choices. Visit megaphone.fm/adchoices

12 Aug 20191h 24min

Reacting To And Analyzing Paul Dillet’s Steroid Cycle In The 90’s

Reacting To And Analyzing Paul Dillet’s Steroid Cycle In The 90’s

This interview discussing Paul Dillet's steroid cycle was recorded by Tom Platz in the 90's. This interview conducted with Tom Platz was intended to remain anonymous. But, the internet is the internet, and people can figure out pretty easily with deciphering the 90's technology of looking at these blurred faces and listening to the noise distortion to make an educated guess about who it is.… Learn more about your ad choices. Visit megaphone.fm/adchoices

11 Aug 20191h 22min

Reacting To And Analyzing Lee Priest’s Steroid Cycle In The 90’s

Reacting To And Analyzing Lee Priest’s Steroid Cycle In The 90’s

This interview discussing Lee Priest's steroid cycle was recorded by Tom Platz in the 90's. This will give an inside look into what top pros with top 0.0001% genetics were doing in the 90's to achieve their physiques. Obviously he could be lying, but I don't see any reason for him to lie, other than to downplay how much of an abuser he could come across as.… Learn more about your ad choices. Visit megaphone.fm/adchoices

11 Aug 201952min

Reacting To And Analyzing Ronnie Coleman’s Steroid Cycle In The 90’s

Reacting To And Analyzing Ronnie Coleman’s Steroid Cycle In The 90’s

This interview discussing Ronnie Coleman's steroid cycle was recorded by Tom Platz in the 90's. I don't think a lot of people know it exists to be honest. Tom Platz basically “anonymously” interviewed 6 top tier IFBB pro bodybuilders who compete at the Olympia level.… Learn more about your ad choices. Visit megaphone.fm/adchoices

24 Juli 201959min

How To Test If Your Deca Is Real | Nandrolone Registers As Testosterone On Blood Tests

How To Test If Your Deca Is Real | Nandrolone Registers As Testosterone On Blood Tests

Nandrolone Registers As Testosterone On Blood Tests Something that isn't common knowledge is that Nandrolone is recognized as Testosterone in standard assays used in the vast majority of blood tests. Typically, this goes completely unnoticed because steroid users only check their Testosterone and Estrogen levels in their blood work, and 99% of those who actually use Nandrolone, use it concurrently with Testosterone as a base.… Learn more about your ad choices. Visit megaphone.fm/adchoices

19 Juli 201912min

The Highest Steroid Dosage Ever “Well Tolerated” In A Clinical Setting

The Highest Steroid Dosage Ever “Well Tolerated” In A Clinical Setting

When it comes to PEDs, the data we derive our conclusions from would ideally come from testing at the clinical level, as opposed to just anecdotes pulled off forums and bro-logs. I found the following study really interesting because to date, no other study has reported findings using a higher steroid dosage.… Learn more about your ad choices. Visit megaphone.fm/adchoices

19 Juli 20196min

My Number 1 Piece Of Advice If You Are Going To Use Steroids

My Number 1 Piece Of Advice If You Are Going To Use Steroids

My number one piece of advice is something I highly doubt you've ever heard, but it's something I wish somebody told me when I was younger. I advise you heed what I write in this article before you haphazardly throw yourself into the domain of performance enhancement.… Learn more about your ad choices. Visit megaphone.fm/adchoices

12 Juli 201912min

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