How Different Anabolic Steroids Can Affect Your Immune System And Vulnerability To Viral Infections
More Plates More Dates17 Mars 2020

How Different Anabolic Steroids Can Affect Your Immune System And Vulnerability To Viral Infections

Both Testosterone and anabolic androgenic steroids (AAS) adversely influence the immune system, affecting leucocyte growth or activity, and antibody and cytokine production, particularly when used at supraphysiological doses, mimicking a condition of secondary immunodeficiency [R, R]. Secondary immunodeficiency, much more common than primary immunodeficiency (that is to say those caused by genetic defects affecting the cells of the immune system), is characterized by various factors that affect a normal immune system, including infectious, iatrogenic, metabolic and environmental factors. These immune deficiencies are manifested clinically with an increased frequency or unusual complications of common infections and occasionally with the onset of opportunistic pathogen infections. https://youtu.be/ceqSC6GYks4 Nandrolone And Anadrol Effects On The Immune System Nandrolone Decanoate and Anadrol directly induce the production of inflammatory cytokines Interleukin 1 Beta (IL-1β) and Tumor Necrosis Factor Alpha (TNF-α) in human peripheral blood leukocyte cultures [R]. Testosterone and DHEA had no direct cytokine inducing effect in the same model. Nandrolone Decanoate also inhibits interferon production in NDV-infected mouse L-929 and human WISH cells. Winstrol And Trenbolone Effects On The Immune System Winstrol and Trenbolone were found to be genotoxic and cytotoxic to human lymphocytes in a dose dependent manner [R]. Testosterone, Teslac, Anavar And Winstrol Effects On The Immune System To evaluate how anabolic steroids affect the immune system, five commercially available steroids with various types of structural differences were studied in a rodent model [R]. Animals were divided into five groups and treated with Testosterone (group 1), Testosterone Propionate (Group 2), the steroidal aromatase inhibitor Testolactone (Teslac) (Group 3), Anavar (Group 4), and Winstrol (Group 5). Significant immunosuppression was observed with all groups. However, by day 10, the Teslac, Anavar and Winstrol treated group showed immunostimulation and actually exceeded baseline immunity while the Testosterone treated groups maintained immunosuppressed. To truly test the effects of endogenous androgens on the immune system a second experiment was then performed. Ten animals maintained in a similar manner to the initial experiment were either treated intact or were castrated and then treated for 8 days, with Anavar (1.1 mg/kg/day), Testosterone (1.1 mg/kg/day) or Anavar combined with physiologic amounts of Testosterone (15 μg/day). Anavar was selected because it has the greatest anabolic activity of all Testosterone analogues as compared to Testosterone (androgenic/anabolic activity = 1:13). In the intact animals after 8 days of treatment with Anavar, serum Testosterone levels were measured by radioimmunoassay on tail vein blood. Levels were either undetectable or very low, reflecting what would be significant HPTA suppression. Immune function (DCH responses) measured at the same time revealed a 41% increase over baseline. The Testosterone treated group experienced a 36% suppression of immune function. Further treatment for 8 days with Anavar combined with physiologic amounts of Testosterone eliminated the immune system enhancement provided by Anavar monotherapy and returned the DCH responses to levels that were not significantly different from baseline. The results were different in the castrated animals. Castration, resulted in an increase in immune (DCH) responses. The mean observed change was 90% greater than intact (pre-castration) baseline. That means that castrated rats had a 90% improvement above and beyond rats that weren’t castrated. Eight day administration of Anavar to these animals had an immunodepressive effect returning the DCH response to baseline. Eight day treatment with Anavar combined with physiologic doses of Testosterone produced an even greater suppression, 45% change from baseline. These observations indicate that immune alterations do occur with anabolic steroids which are immunosuppressive when the steroid nucleus is intact and immunostimulatory with nuclear alterations. How Steroids Influence Immune Function The hypothesis to explain the immune system responses to steroids is as follows. Exogenous androgenic anabolic steroids produce two effects on the immune system: (A) a direct early effect on immune function which is suppressive and, (B) an indirect delayed stimulatory effect mediated through the negative feedback on the pituitary. (B) results in inhibition of gonadal Testosterone through diminished LH release. A decrease in the synthesis of Testosterone results in low serum Testosterone level and immune stimulation. Castration, by abolishing the modulation of Testosterone secretion eliminates the effect of (B) but leaves (A) intact. In summation, the more suppressive a steroid is the more it can indirectly enhance immune function, simply by suppressing the endogenous production of Testosterone and its metabolites. However, anabolic steroids will also be genotoxic and cytotoxic to human lymphocytes in a dose dependent manner. So, the only reason anabolic steroids can enhance immunity is by being more tissue selective than Testosterone and by shutting down the HPTA, not by inherently being protective. They too will be inherently immunosuppressive, just to a lesser degree based on their tissue selectivity and magnitude of impact on endogenous androgen production suppression. At the end of the day, the data all suggests that the lower your levels of steroids are in the body, the higher level your immune system will function at in parallel. Are You Increasing Your Risk Of Viral Infection When You Are On Cycle? In summary, the vast majority of studies suggest that steroid use decreases antibody formation, Natural Killer (NK) lymphocyte activity, T and B lymphocyte maturation and stimulation resulting in immunosuppression [R]. Supraphysiological doses of common anabolic steroids have been shown to directly influence the production of certain cytokines, altering immune function. The results from both animal and human studies suggest that supraphysiological doses of AAS can negatively impact the immune system. The takeaway from all of this is that with an easily spread virus infecting thousands of people throughout the world right now, it would be prudent to reduce your exogenous AAS use at least down to therapeutic levels to support immune function during this time where having increased vulnerability to viral infection is the most risky. Regardless if you are young and believe you are invincible based on the mortality rate statistics showing that the elderly are the most at risk of being symptomatic or ending up in critical condition, you may still be increasing your chances of becoming an infected carrier who then transmits the virus to the elderly (including your parents or grandparents) as a result of self-induced immunosuppression. Learn more about your ad choices. Visit megaphone.fm/adchoices

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How Gordon Ryan Saved Nicky Rod's Life

How Gordon Ryan Saved Nicky Rod's Life

⚕️ Use code "MPMD" for 10% off our in-depth blood test panels at Marek Health: https://marekhealth.com/mpmd 📌 Check out the full podcast here: https://youtu.be/bLyFvocD-eU?si=mqvX0-GOnUsAsVKR ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ TWITTER: https://twitter.com/Derek_Fitness SNAPCHAT: https://www.snapchat.com/add/derek-fit TIKTOK: https://www.tiktok.com/@moreplates FACEBOOK: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #craigjones #gordonryan #nickyrod ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

19 Aug 20245min

How Hard Is It To Get A Black Belt? 🥋

How Hard Is It To Get A Black Belt? 🥋

📌 Check out the full podcast here: https://youtu.be/6uy75kr_O5k ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ TWITTER: https://twitter.com/Derek_Fitness SNAPCHAT: https://www.snapchat.com/add/derek-fit TIKTOK: https://www.tiktok.com/@moreplates FACEBOOK: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #craigjones #cji #jiujitsu ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

19 Aug 20247min

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🐟 Omega-3 Elixir™ Is Now Live! The Most Robust & Rigorously Vetted Omega-3 Support: https://gorillamind.com/products/omega-3-elixir | code "MPMD" for 10% off (and another 20% off on subscriptions) 📌 The Omega-3 Index Blood Test: https://marekdiagnostics.com/products/omega-check | code "MPMD" for 10% off ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ TWITTER: https://twitter.com/Derek_Fitness SNAPCHAT: https://www.snapchat.com/add/derek-fit TIKTOK: https://www.tiktok.com/@moreplates FACEBOOK: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #fishoil #omega3 #supplements ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

16 Aug 202416min

Becoming Elite, PEDs, BJJ, MMA, & The HIGH STAKES $3 Million CJI Tournament - Craig Jones

Becoming Elite, PEDs, BJJ, MMA, & The HIGH STAKES $3 Million CJI Tournament - Craig Jones

⚕️ Use code "MPMD" for 10% off our in-depth blood test panels at Marek Health: https://marekhealth.com/mpmd ———————————— 🕑 Time Stamps: 0:00:00 - Craigs Jones’ first time in Canada and the guy who threatened to kill him 0:02:00 - Who is Craig Jones? 0:02:57 - The $3 million CJI tournament anonymous donor, and bringing $1 million cash on Joe Rogan’s podcast 0:05:43 - Why Craig started Jiu-Jitsu. MMA was illegal in Australia 0:06:47 - Why Joe Rogan refuses to come to Canada. Would Derek ever leave Canada? 0:12:45 - Jiu-Jitsu vs MMA and the ROI for the risk of brain damage 0:13:23 - Beating drug testing in tested sports 0:14:29 - Who are the most elite Jiu-Jitsu athletes who could also do well in MMA? 0:16:56 - There was no money in Jiu-Jitsu when Craig started 0:18:01 - The misconception that Jiu-Jitsu isn’t gay and weird 0:19:38 - The top 3 martial arts you should learn to defend yourself 0:21:12 - The most important form of combat to learn first before anything else 0:21:59 - The most ineffective combat skill that is often mistakenly believed to be useful 0:24:29 - Bragging rights of winning tournaments 0:25:59 - How B-Team is playing 4D chess by claiming to be the second best 0:27:40 - Craig’s Instagram beefs, and who the weirdest athletes are 0:28:50 - Brazilian Jiu-Jitsu (BJJ) vs. Jiu-Jitsu 0:30:21 - The kids who came up to Derek on the beach asking about building muscle for Jiu-Jitsu 0:31:33 - How train to progress as quickly as possible in Jiu-Jitsu 0:32:41 - The curse of Larry Wheels, and athletes ruining their careers by training stupidly 0:35:52 - The performance downsides of getting juiced out of your mind massive for Jiu-Jitsu 0:37:24 - The Danaher Death Squad and why Craig, Nicky Ryan, Nicky Rod, and Ethan Crelinsten left 0:39:34 - How hard is it to get a black belt and how long does it take? Is it a covert multi-level marketing scheme? 0:47:28 - How to optimize week of training to max out progress in Jiu-Jitsu 0:49:28 - How to learn submissions as quickly as possible 0:51:39 - Craig's tier list for the best and worst submissions 0:55:45 - The craziest submission Craig has ever hit 0:56:44 - Jiu-Jitsu paywalled instructional videos from elite athletes 1:00:00 - Why most of the best Jiu-Jitsu athletes in the world make less than $100K per year 1:02:27 - The top prizes for winning the most elite submission grappling competition in the world (ADCC), and now the $2.6 million at stake for the first Craig Jones Invitational (CJI) 1:03:30 - The identity of the anonymous donor who put up $3 million for CJI 1:05:15 - Why Craig is so motivated to take down ADCC 1:07:18 - Sponsor: Marek Health 1:08:37 - The super fights, custom fight pit to push action, and why CJI will be the most elite, high stakes, grappling tournament on earth 1:18:28 - The origins of the Abu Dhabi Combat Club (ADCC) 1:19:27 - Craig’s blood work and his review of Marek Health so far 1:21:27 - The importance of expert oversight in Jiu-Jitsu to optimize health, performance, and longevity in the sport 1:25:48 - Do you need to be on PEDs to excel in Jiu-Jitsu? 1:29:15 - The world championship combination of autism and steroids in Jiu-Jitsu 1:30:51 - Life changing money at CJI. Winning $1 million at CJI vs. ADCC prestige ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ TWITTER: https://twitter.com/Derek_Fitness SNAPCHAT: https://www.snapchat.com/add/derek-fit TIKTOK: https://www.tiktok.com/@moreplates FACEBOOK: https://www.facebook.com/moreplates/ ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

14 Aug 20241h 36min

Are Men Beating Women At The Olympics? - The Truth (comprehensive dissection)

Are Men Beating Women At The Olympics? - The Truth (comprehensive dissection)

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12 Aug 202459min

This Is The Power Of Steroids...

This Is The Power Of Steroids...

📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks) 💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order ⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J | discount code "MPMD" for 10% off your entire order 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order 🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order 🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv 🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ THREADS: https://www.threads.net/@moreplatesmoredates FACEBOOK: https://www.facebook.com/moreplates/ SNAPCHAT: https://www.snapchat.com/add/derek-fit TWITTER: https://twitter.com/Derek_Fitness TIKTOK: https://www.tiktok.com/@moreplates ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #bodybuilding #steroids #bodytransformation  ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

3 Juli 202416min

TRT Dosing And Frequency Breakdown With Dr. Peter Attia

TRT Dosing And Frequency Breakdown With Dr. Peter Attia

📌 Check out the full podcast here: https://youtu.be/JNpgqpyzW98 ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: http://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks) 💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order ⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791 🧪 Blood Work: http://bit.ly/2wI3k9J | discount code "MPMD" for 10% off your entire order 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order 🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order 🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): http://bit.ly/2JmpTGv 🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ THREADS: https://www.threads.net/@moreplatesmoredates FACEBOOK: https://www.facebook.com/moreplates/ SNAPCHAT: https://www.snapchat.com/add/derek-fit TWITTER: https://twitter.com/Derek_Fitness TIKTOK: https://www.tiktok.com/@moreplates ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #moreplatesmoredates #peterattia #testosterone   ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

25 Juni 202413min

How To Determine If You Have IFBB Pro Bodybuilder Genetics

How To Determine If You Have IFBB Pro Bodybuilder Genetics

📌 Check out the full podcast here: https://youtu.be/IfRbc1E9boM ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: http://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks) 💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order ⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791 🧪 Blood Work: http://bit.ly/2wI3k9J | discount code "MPMD" for 10% off your entire order 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order 🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order 🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): http://bit.ly/2JmpTGv 🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ THREADS: https://www.threads.net/@moreplatesmoredates FACEBOOK: https://www.facebook.com/moreplates/ SNAPCHAT: https://www.snapchat.com/add/derek-fit TWITTER: https://twitter.com/Derek_Fitness TIKTOK: https://www.tiktok.com/@moreplates ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #stanefferding #bodybuilding #ifbb  ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

9 Juni 20243min

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