144 The Case of Premature Aging: How Lifestyle Changes and DNA Methylation Lead to Big Breakthrough with Dr. Kara Fitzgerald

144 The Case of Premature Aging: How Lifestyle Changes and DNA Methylation Lead to Big Breakthrough with Dr. Kara Fitzgerald

The Case:

  • Laura has thyroid issues causing her to feel overweight and her constantly dry skin made her feel like she was aging too fast.
  • She suspected that her issues might be genetic so she did a DNA test which revealed that she had the MTHFR gene.
  • She tried biohacking; taking high doses of B vitamins and a cocktail of other supplements but nothing got her the results she was looking for.

Investigation
My suspicions were that her various supplements might not be right for her. I also wanted to take a closer look at her diet and lifestyle.
Because I suspected that the answers were going to be found at the intersection of genetics, diet, and lifestyle I knew that Dr. Kara Fitzgerald would be the perfect person to consult with since she is an expert in epigenetics, nutrition, and aging. She is the author of two incredible books, Younger You: Reduce Your Bio Age and Live Longer, Better and Better Broths & Healing Tonics: 75 Bone Broth and Vegetarian Broth-Based Recipes for Everyone.
Unveiling the Power of Epigenetics
We often associate our health, thyroid function, and immune system with genetics and autoimmunity. However, as Dr. Kara explains, it is not our genes alone that determine our level of health, immune system function, or even our age. Instead, it is our epigenetics that play a significant role. I know there's a lot of confusion surrounding this topic, and in this episode, Dr. Kara shed some light on it.
She explains that in the early 2000s, scientists successfully deciphered the human genome. They discovered that we possess a little over 23,000 genes, and many believed that this knowledge would provide a clear roadmap to understanding and treating diseases. However, the reality turned out to be quite different. In over 90% of cases, genes alone do not determine our health outcomes. For most of us, the key lies in how our genes are being turned on and off—a fascinating field known as epigenetics that we’ve covered before in episode 143.
Unleashing the Potential of Epigenetic Expression
Epigenetics emerged as a prominent field of study after the completion of the Human Genome Project. It explores the factors that influence gene expression, such as our diet, exposure to toxins, stress levels, social connections, and exercise habits. Simply put, we have the power to determine which genes are activated and which ones remain dormant. Ideally, we want to activate the genes associated with health, longevity, and overall well-being while silencing those that contribute to disease progression.
This realization is particularly empowering for individuals like Laura, who believed that her family history of Hashimoto's meant she was destined to follow the same path. However, epigenetics shows us that we are not bound by our genetic heritage alone.
Lifestyle and Nutrition: The Epigenetic Keys
Dr. Kara dives into the exciting realm of lifestyle and nutrition, revealing some of the most significant factors that influence gene expression. Understanding these keys can help us unlock the potential for anti-aging, detoxification, and disease prevention.
1. Diet Program: Dr. Kara shares insights from a groundbreaking study on biological aging, which focused on DNA methylation—a marker of aging and gene expression changes. The study participants followed a specific diet program designed to optimize gene expression. The key elements of this diet program include:

  • Veggies and Greens: Emphasizing a plant-rich diet with an abundance of greens and cruciferous vegetables, cooked to support thyroid health.
  • Low-Glycemic and Fruit-Dense: Opting for low-glycemic vegetables and incorporating dark berries rich in polyphenols.
  • Smart Protein Choices: Eggs and liver (if open to consuming them) are excellent gene whispering foods, while seeds, nuts, and fatty fish provide essential nutrients.
  • Healthy Oils: Including extra virgin olive oil and coconut oil in cooking.
  • Vitamin D and Mushrooms: Ensuring sufficient vitamin D intake and recognizing the gene-regulating properties of mushrooms, such as shiitake and maitake.

2. Herbs and Spices: Dr. Kara highlights the impact of polyphenols found in various herbs and spices. Rosemary, thyme, oregano, curcumin, turmeric, quercetin, and resveratrol are just a few examples of potent gene regulators.

It's important to note that while we may inherit some gene expression patterns from our parents and ancestors, we still hold the reins and have the power to influence our health destiny. Understanding this gives us the opportunity to make informed choices and take control of our well-being.

Dr. Kara emphasizes the vital connection between epigenetics, aging, and thyroid disease. Aging acts as a primary driver for various chronic conditions, including hypothyroidism, Graves' disease, and subclinical hypothyroidism. Exploring the changes in epigenetic expression and DNA methylation provides valuable insights into the underlying mechanisms of these conditions. Epigenetic Lifestyle: A Holistic Approach to Optimal Health

Dr. Kara uses her study and others as examples to showcase that it's not just about individual foods but a synergistic combination that maximizes the effects on gene expression. She explains that her program incorporates low glycemic choices, intermittent fasting, exercise, and other crucial lifestyle factors. The Power of Simple Lifestyle Changes

Dr. Kara says the key to success is by making simple, doable lifestyle changes to improve our health and slow down the aging process. She emphasizes that the goal is not to engage in extreme measures but rather to focus on sustainable habits that can positively impact our overall well-being. That was the motivation behind her research team’s design of a program called "Younger You" that aimed to create meaningful changes in participants' health. The program included a simple exercise prescription, prioritized quality sleep, incorporated basic meditation practices, and recommended the use of a greens powder and probiotic supplement.

The results she shared were truly astonishing to me. Understanding the Role of DNA Methylation

DNA methylation plays a crucial role in gene expression and epigenetics. We’ve talked about this before (on this episode about the MTHFR gene) but it’s important to go beyond that. Methylation is involved in numerous essential processes in the body, from metabolizing hormones and neurotransmitters to maintaining optimal cell function. Methylation is influenced by various factors, including nutrients, gut health, and the microbiome.

Comprehensive testing is needed to assess methylation status and overall metabolic function. This involves looking at biomarkers such as homocysteine and methylation cycle intermediates. A functional medicine approach goes beyond the methylation cycle and explores other metabolic aspects, including gut health and individual nutrient needs. By understanding each person's unique metabolic profile, personalized interventions can be implemented to o...

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197 What No One Told You About The Connection of Progesterone, Estrogen, and Hashimoto’s with Dr. Felice Gersh (Part 1)

197 What No One Told You About The Connection of Progesterone, Estrogen, and Hashimoto’s with Dr. Felice Gersh (Part 1)

In this episode of Thyroid Mystery Solved, Inna welcomes back the brilliant Dr. Felice Gersh for a conversation that takes Hashimoto’s and hormones to a whole new level. Together, they dive deep into the role of estrogen and progesterone in regulating the immune system, inflammation, and thyroid health. Most people have only heard the basics about these hormones, but as Dr. Gersh explains, the story goes far beyond reproduction. From Hashimoto’s flares that appear around menstrual cycles to the critical impact of hormones during perimenopause and menopause, this discussion unpacks what most doctors never tell their patients and you are going to be amazed!Dr. Gersh also shines a light on how misconceptions about hormones, especially progesterone, have shaped conventional medicine and why so many women are left without the support they truly need. This episode is part one of a two-part series, and it is filled with insights that will completely change the way you think about hormones and Hashimoto’s.----------For full show notes, please see https://innatopiler.com/podcasts/connection-progesterone-estrogen-and-hashimotos-dr-felice-gersh/Get ThyroLove - the first all in one bottle multi-nutrient comprehensive formula designed specifically for those with Hashimoto’s at ThyroLove.com - use code “Podcast” to get 10% off and free shipping For more information about everything Hashimoto’s please visit InnaTopiler.comIf you are struggling to lose weight with Hashimoto’s, Inna has a 10 day plan just for you at InnaTopiler.com/jumpstartIf you need help with fatigue or brain fog with Hashimoto’s, please check out Inna’s 9 Day Exhaustion Solution at innatopiler.com/energyIf you don’t yet know your thyroid type, please be sure you sign up for Inna’s next free training at InnaTopiler.com/zoomcall

4 Sep 45min

196 Why Positive Thinking Can Backfire with Hashimoto’s with Anat Peri

196 Why Positive Thinking Can Backfire with Hashimoto’s with Anat Peri

In this powerful episode, Inna is joined by transformational leader and inner child expert Anat Peri to explore an unexpected twist in the Hashimoto’s healing journey. Together, they dive into the case of Jessica, who was doing all the “right” things, following the AIP diet, taking supplements, working on her mindset, but still felt exhausted and stuck. Her symptoms weren’t improving, and her doctor’s solution was to increase her medication yet again.The turning point came when she uncovered something deeper. Jessica was trying so hard to stay positive, think positive, do her affirmations because that is what she was told she should be doing. However by doing that, she was unintentionally overriding her true emotions and it made her feel way worse.Anat explains how this kind of forced positivity can be a detriment because it can actually create stress in the nervous system, keeping the body in a chronic state of fight, flight, or freeze. This episode unpacks how overriding your feelings can actually worsen autoimmune symptoms and why true healing starts with emotional safety.Anat also shares the science behind how the nervous system reacts faster than the conscious mind, how inner child work helps create safety, and why nervous system regulation must come before mindset work can truly be effective. From breathwork to sensation naming to reparenting tools, you’ll learn how to create space for your emotions and support your healing from the inside out.This episode is an essential listen for anyone who has tried it all and still feels like something is missing. It might not be about doing more. It might be about feeling more.For full show notes, please see:https://innatopiler.com/podcasts/positive-thinking-hashimotos-anat-peri/Get ThyroLove - the first all in one bottle multi-nutrient comprehensive formula designed specifically for those with Hashimoto’s at ThyroLove.com - use code “Podcast” to get 10% off and free shipping For more information about everything Hashimoto’s please visit InnaTopiler.comIf you are struggling to lose weight with Hashimoto’s, Inna has a 10 day plan just for you at InnaTopiler.com/jumpstartIf you need help with fatigue or brain fog with Hashimoto’s, please check out Inna’s 9 Day Exhaustion Solution at innatopiler.com/energyIf you don’t yet know your thyroid type, please be sure you sign up for Inna’s next free training at InnaTopiler.com/zoomcall

24 Juli 54min

195 The Surprising Empath–Thyroid Connection with Kristen Schwartz

195 The Surprising Empath–Thyroid Connection with Kristen Schwartz

If you have Hashimoto’s, there’s a very real chance you’re also an empath and you may not even realize it.This matters more than you think. Because when you’re highly sensitive and constantly absorbing everything around you (other people’s energy, emotions, even stress), your nervous system takes the hit. And when the nervous system is in overdrive, it becomes very hard to heal, no matter how clean your diet is or how many supplements you take.In this episode, Inna is joined by trauma-informed coach and empath expert Kristen Schwartz to talk about something that’s rarely discussed in the Hashimoto’s world: how being an unrecognized empath can be one of the biggest hidden blocks to healing. Kristen breaks down how fatigue, overstimulation, anxiety, heart palpitations, and even sleep issues can all trace back to nervous system dysregulation and how this shows up differently in sensitive people.You’ll learn how to tell if this is what’s really happening in your body, how to start regulating (without adding more to your to-do list), and how to gently reconnect to yourself without pressure or performance. Kristen shares simple but powerful shifts that help you reclaim your energy, feel safe in your body again, and finally get unstuck.If you've ever felt like you're doing all the right things but still feel wired, tired, or anxious, this conversation could be the missing link. You’ll walk away with a deeper understanding of what’s really going on under the surface and what to do about it.----------For full show notes, please see:https://innatopiler.com/podcasts/empath-thyroid-connection-kristen-schwartz/Get ThyroLove - the first all in one bottle multi-nutrient comprehensive formula designed specifically for those with Hashimoto’s at ThyroLove.com - use code “Podcast” to get 10% off and free shipping For more information about everything Hashimoto’s please visit InnaTopiler.comIf you are struggling to lose weight with Hashimoto’s, Inna has a 10 day plan just for you at InnaTopiler.com/jumpstartIf you need help with fatigue or brain fog with Hashimoto’s, please check out Inna’s 9 Day Exhaustion Solution at innatopiler.com/energyIf you don’t yet know your thyroid type, please be sure you sign up for Inna’s next free training at InnaTopiler.com/zoomcall

10 Juli 50min

194 Conflicting Hashimoto’s Advice: How To Find Your Path to Healing

194 Conflicting Hashimoto’s Advice: How To Find Your Path to Healing

When you’re living with Hashimoto’s,  it’s easy to end up overwhelmed, especially when you’re getting conflicting advice from different practitioners. In this episode, Inna shares a real-life case where a client was stuck in that very situation, caught between protocols and unsure how to move forward. What helped wasn’t more advice, instead it was learning to trust her own intuition.To explore this idea further, Inna is joined by Karly Ashworth, a transformational coach and intuitive guide who helps people reconnect to their inner voice and find clarity. Together, they talk about how tuning into your intuition can help you navigate confusing symptoms, make better health decisions, and even uncover emotional patterns that might be affecting your thyroid.They dive into what intuition really is (and why we all have it), how it relates to the throat chakra and the thyroid, and why emotional triggers such as indecision or self-doubt can sometimes do just as much damage as physical ones. Karly also shares practical ways to quiet the noise, get grounded, and start recognizing the signals your body is already sending you.Whether you’ve been second-guessing your health decisions or you’ve just felt out of touch with your body, this episode is a powerful reminder that sometimes, the answers you’re looking for aren’t out there but they’re already within.For full show notes, please see (TIM PLEASE ADD LINK)Get ThyroLove - the first all in one bottle multi-nutrient comprehensive formula designed specifically for those with Hashimoto’s at ThyroLove.com - use code “Podcast” to get 10% off and free shipping For more information about everything Hashimoto’s please visit InnaTopiler.comIf you are struggling to lose weight with Hashimoto’s, Inna has a 10 day plan just for you at InnaTopiler.com/jumpstartIf you need help with fatigue or brain fog with Hashimoto’s, please check out Inna’s 9 Day Exhaustion Solution at innatopiler.com/energyIf you don’t yet know your thyroid type, please be sure you sign up for Inna’s next free training at InnaTopiler.com/zoomcall

26 Juni 50min

193 Root Canals, Cavities, and Hashimoto’s: What Your Dentist Isn’t Telling You with Dr. Michelle Jorgensen

193 Root Canals, Cavities, and Hashimoto’s: What Your Dentist Isn’t Telling You with Dr. Michelle Jorgensen

When a patient has tried every clean-eating plan, every supplement protocol, and every practitioner,  but is still exhausted, anxious, and foggy  it’s time to look where no one else has. In this episode, Inna teams up with functional dentist Dr. Michelle Jorgensen to explore a very overlooked trigger and aggravator for Hashimoto’s symptoms: your mouth.Through the case of “Cindy,” a Hashimoto’s patient who did everything right but still wasn’t getting better, Inna and Dr. Michelle reveal how hidden dental infections, past root canals, and even the materials used in old dental work can silently drive inflammation and autoimmune flares. What looks like “perfect” dental health on X-rays might actually be masking deep, ongoing issues that most conventional dentists never catch.Dr. Michelle brings her unique insight as a dentist-turned-health detective, showing how problems like cavitations, mixed metals, and even mouth breathing can create a ripple effect on the immune system, the microbiome, and the thyroid. She also explains how to safely investigate and address these issues  and why healing often requires asking the questions no one else is asking.This episode opens a powerful new conversation for anyone with Hashimoto’s who still doesn’t feel well despite doing “everything right” and exactly what you can do to explore what your mouth is trying to tell you.----------For full show notes, please see:https://innatopiler.com/podcasts/root-canals-cavities-hashimotos-dentist-dr-michelle-jorgensen/Get ThyroLove - the first all in one bottle multi-nutrient comprehensive formula designed specifically for those with Hashimoto’s at ThyroLove.com - use code “Podcast” to get 10% off and free shipping For more information about everything Hashimoto’s please visit InnaTopiler.comIf you are struggling to lose weight with Hashimoto’s, Inna has a 10 day plan just for you at InnaTopiler.com/jumpstartIf you need help with fatigue or brain fog with Hashimoto’s, please check out Inna’s 9 Day Exhaustion Solution at innatopiler.com/energyIf you don’t yet know your thyroid type, please be sure you sign up for Inna’s next free training at InnaTopiler.com/zoomcall

12 Juni 52min

192 The Emotional Root of Chronic Symptoms in Hashimoto’s with Lizzy Swick

192 The Emotional Root of Chronic Symptoms in Hashimoto’s with Lizzy Swick

If you’ve ever felt like you’ve tried everything…very diet, every supplement, every protocol, but your Hashimoto’s symptoms still aren’t budging, this episode might be the missing link. In this tender and deeply personal conversation, Inna sits down with her dear friend and colleague Lizzy Swick, RDN, to explore a part of healing that’s so often overlooked: the emotional and nervous system layer. Lizzy shares her own journey of chronic migraines, pain, and doing all the right things until she discovered that true progress began when she stopped doing more and started feeling more.Together, they unpack what it really means to feel safe in your body and how emotions, past experiences, and the way we push ourselves can quietly drive inflammation, fatigue, and even autoimmunity. You’ll hear practical tools like "rage on the page" journaling, embodiment meditation, and the internal shifts that helped Lizzy finally get relief after years of searching. It’s gentle, honest, and eye-opening in the most beautiful way.This conversation is one that Inna truly hopes you’ll take to heart. It’s not just about healing your thyroid, it’s about healing you. If you’ve been stuck, if nothing is working, or if you’ve ever wondered whether your emotions and nervous system might be part of the puzzle, this episode will feel like a breath of fresh air. Please listen, it might be the turning point you didn’t know you needed.----------For full show notes, please see https://innatopiler.com/podcasts/root-chronic-symptoms-hashimotos-lizzy-swick/Get ThyroLove - the first all in one bottle multi-nutrient comprehensive formula designed specifically for those with Hashimoto’s at ThyroLove.com - use code “Podcast” to get 10% off and free shipping For more information about everything Hashimoto’s please visit InnaTopiler.comIf you are struggling to lose weight with Hashimoto’s, Inna has a 10 day plan just for you at InnaTopiler.com/jumpstartIf you need help with fatigue or brain fog with Hashimoto’s, please check out Inna’s 9 Day Exhaustion Solution at innatopiler.com/energyIf you don’t yet know your thyroid type, please be sure you sign up for Inna’s next free training at InnaTopiler.com/zoomcall

29 Maj 50min

191 Hashimoto’s and the Hidden Growth You Might Not See Yet

191 Hashimoto’s and the Hidden Growth You Might Not See Yet

When you’re in the thick of it, whether it’s fatigue, brain fog, a flare, or something even bigger, it’s so easy to feel like you’re losing yourself. But what if something deeper is happening beneath the surface? In this heartfelt solo episode, Inna shares a powerful reframe that might just change how you see your Hashimoto’s journey… and your life.Drawing from her own healing path with Hashimoto’s and the ongoing challenges she’s facing with her son Jake’s autism and PANDAS diagnosis, Inna opens up about what it means to go through something and become someone in the process. She shares how surrender, patience, humor, and deep empathy have shaped her, not just as a mom, but as a woman and practitioner.This episode is an invitation to pause and reflect on your own journey, what it’s teaching you, how it’s changing you, and who you’re becoming through it all. If you’ve ever felt alone in your struggles or unsure of your path, this conversation will help you feel seen, grounded, and more hopeful.----------For full show notes, please see https://innatopiler.com/podcasts/hashimotos-hidden-growth/Get ThyroLove - the first all in one bottle multi-nutrient comprehensive formula designed specifically for those with Hashimoto’s at ThyroLove.com - use code “Podcast” to get 10% off and free shipping For more information about everything Hashimoto’s please visit InnaTopiler.comIf you are struggling to lose weight with Hashimoto’s, Inna has a 10 day plan just for you at InnaTopiler.com/jumpstartIf you need help with fatigue or brain fog with Hashimoto’s, please check out Inna’s 9 Day Exhaustion Solution at innatopiler.com/energyIf you don’t yet know your thyroid type, please be sure you sign up for Inna’s next free training at InnaTopiler.com/zoomcall

15 Maj 22min

190 The Hidden Factor Behind Brain Fog and Fatigue in Hashimoto’s with Inna Topiler

190 The Hidden Factor Behind Brain Fog and Fatigue in Hashimoto’s with Inna Topiler

There’s one hidden factor that could be draining your energy and clouding your brain, and most people with Hashimoto’s have no idea it’s happening.In this episode, Inna reveals the overlooked role that poor blood and lymph flow play in fatigue and brain fog, and very specific things that can make a big difference in how your brain functions and how your body feels.She walks you through the exact steps you can take right now to improve circulation, clear your head, and start feeling better with gentle, doable strategies that actually work for Hashimoto’s. Plus, she dives into the full picture of why energy gets blocked, including deeper layers like blood sugar, mitochondrial inflammation, adrenal rhythm, and nutrient deficiencies. It’s everything you need to understand why you’re still tired and what to do about it.If you’ve been doing everything “right” but still feel off, you need to hear this.----------For full show notes, please see https://innatopiler.com/podcasts/brain-fog-fatigue-hashimotos-inna-topiler/Get ThyroLove - the first all in one bottle multi-nutrient comprehensive formula designed specifically for those with Hashimoto’s at ThyroLove.com - use code “Podcast” to get 10% off and free shipping For more information about everything Hashimoto’s please visit InnaTopiler.comIf you are struggling to lose weight with Hashimoto’s, Inna has a 10 day plan just for you at InnaTopiler.com/jumpstartIf you need help with fatigue or brain fog with Hashimoto’s, please check out Inna’s 9 Day Exhaustion Solution at innatopiler.com/energyIf you don’t yet know your thyroid type, please be sure you sign up for Inna’s next free training at InnaTopiler.com/zoomcall

1 Maj 18min

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