144 The Case of Premature Aging: How Lifestyle Changes and DNA Methylation Lead to Big Breakthrough with Dr. Kara Fitzgerald

144 The Case of Premature Aging: How Lifestyle Changes and DNA Methylation Lead to Big Breakthrough with Dr. Kara Fitzgerald

The Case:

  • Laura has thyroid issues causing her to feel overweight and her constantly dry skin made her feel like she was aging too fast.
  • She suspected that her issues might be genetic so she did a DNA test which revealed that she had the MTHFR gene.
  • She tried biohacking; taking high doses of B vitamins and a cocktail of other supplements but nothing got her the results she was looking for.

Investigation
My suspicions were that her various supplements might not be right for her. I also wanted to take a closer look at her diet and lifestyle.
Because I suspected that the answers were going to be found at the intersection of genetics, diet, and lifestyle I knew that Dr. Kara Fitzgerald would be the perfect person to consult with since she is an expert in epigenetics, nutrition, and aging. She is the author of two incredible books, Younger You: Reduce Your Bio Age and Live Longer, Better and Better Broths & Healing Tonics: 75 Bone Broth and Vegetarian Broth-Based Recipes for Everyone.
Unveiling the Power of Epigenetics
We often associate our health, thyroid function, and immune system with genetics and autoimmunity. However, as Dr. Kara explains, it is not our genes alone that determine our level of health, immune system function, or even our age. Instead, it is our epigenetics that play a significant role. I know there's a lot of confusion surrounding this topic, and in this episode, Dr. Kara shed some light on it.
She explains that in the early 2000s, scientists successfully deciphered the human genome. They discovered that we possess a little over 23,000 genes, and many believed that this knowledge would provide a clear roadmap to understanding and treating diseases. However, the reality turned out to be quite different. In over 90% of cases, genes alone do not determine our health outcomes. For most of us, the key lies in how our genes are being turned on and off—a fascinating field known as epigenetics that we’ve covered before in episode 143.
Unleashing the Potential of Epigenetic Expression
Epigenetics emerged as a prominent field of study after the completion of the Human Genome Project. It explores the factors that influence gene expression, such as our diet, exposure to toxins, stress levels, social connections, and exercise habits. Simply put, we have the power to determine which genes are activated and which ones remain dormant. Ideally, we want to activate the genes associated with health, longevity, and overall well-being while silencing those that contribute to disease progression.
This realization is particularly empowering for individuals like Laura, who believed that her family history of Hashimoto's meant she was destined to follow the same path. However, epigenetics shows us that we are not bound by our genetic heritage alone.
Lifestyle and Nutrition: The Epigenetic Keys
Dr. Kara dives into the exciting realm of lifestyle and nutrition, revealing some of the most significant factors that influence gene expression. Understanding these keys can help us unlock the potential for anti-aging, detoxification, and disease prevention.
1. Diet Program: Dr. Kara shares insights from a groundbreaking study on biological aging, which focused on DNA methylation—a marker of aging and gene expression changes. The study participants followed a specific diet program designed to optimize gene expression. The key elements of this diet program include:

  • Veggies and Greens: Emphasizing a plant-rich diet with an abundance of greens and cruciferous vegetables, cooked to support thyroid health.
  • Low-Glycemic and Fruit-Dense: Opting for low-glycemic vegetables and incorporating dark berries rich in polyphenols.
  • Smart Protein Choices: Eggs and liver (if open to consuming them) are excellent gene whispering foods, while seeds, nuts, and fatty fish provide essential nutrients.
  • Healthy Oils: Including extra virgin olive oil and coconut oil in cooking.
  • Vitamin D and Mushrooms: Ensuring sufficient vitamin D intake and recognizing the gene-regulating properties of mushrooms, such as shiitake and maitake.

2. Herbs and Spices: Dr. Kara highlights the impact of polyphenols found in various herbs and spices. Rosemary, thyme, oregano, curcumin, turmeric, quercetin, and resveratrol are just a few examples of potent gene regulators.

It's important to note that while we may inherit some gene expression patterns from our parents and ancestors, we still hold the reins and have the power to influence our health destiny. Understanding this gives us the opportunity to make informed choices and take control of our well-being.

Dr. Kara emphasizes the vital connection between epigenetics, aging, and thyroid disease. Aging acts as a primary driver for various chronic conditions, including hypothyroidism, Graves' disease, and subclinical hypothyroidism. Exploring the changes in epigenetic expression and DNA methylation provides valuable insights into the underlying mechanisms of these conditions. Epigenetic Lifestyle: A Holistic Approach to Optimal Health

Dr. Kara uses her study and others as examples to showcase that it's not just about individual foods but a synergistic combination that maximizes the effects on gene expression. She explains that her program incorporates low glycemic choices, intermittent fasting, exercise, and other crucial lifestyle factors. The Power of Simple Lifestyle Changes

Dr. Kara says the key to success is by making simple, doable lifestyle changes to improve our health and slow down the aging process. She emphasizes that the goal is not to engage in extreme measures but rather to focus on sustainable habits that can positively impact our overall well-being. That was the motivation behind her research team’s design of a program called "Younger You" that aimed to create meaningful changes in participants' health. The program included a simple exercise prescription, prioritized quality sleep, incorporated basic meditation practices, and recommended the use of a greens powder and probiotic supplement.

The results she shared were truly astonishing to me. Understanding the Role of DNA Methylation

DNA methylation plays a crucial role in gene expression and epigenetics. We’ve talked about this before (on this episode about the MTHFR gene) but it’s important to go beyond that. Methylation is involved in numerous essential processes in the body, from metabolizing hormones and neurotransmitters to maintaining optimal cell function. Methylation is influenced by various factors, including nutrients, gut health, and the microbiome.

Comprehensive testing is needed to assess methylation status and overall metabolic function. This involves looking at biomarkers such as homocysteine and methylation cycle intermediates. A functional medicine approach goes beyond the methylation cycle and explores other metabolic aspects, including gut health and individual nutrient needs. By understanding each person's unique metabolic profile, personalized interventions can be implemented to o...

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189 The Surprising Principle That Simplifies Hashimoto’s Healing with Inna Topiler

189 The Surprising Principle That Simplifies Hashimoto’s Healing with Inna Topiler

Ever feel like sticking to a healthy routine is way harder than it should be? In this episode, Inna shares the one mindset shift that can completely change how you approach your habits, especially when living with Hashimoto’s.She introduces the concept of “99% is hard, 100% is easy” and explains how partial commitment, whether to diet, sleep, supplements, or stress management, can actually make things feel more overwhelming. But when you go all in, in a very specific way that she explains, everything gets simpler.Inna walks through real-life examples from her own routine, from skipping gluten to sticking to a solid bedtime (even when a show has 4 minutes left!). She also breaks down why this shift is so powerful for managing Hashimoto’s and thyroid issues where inflammation, stress, and blood sugar all play a major role.You’ll walk away with a new way of thinking about your choices, plus practical strategies to make those choices easier. If you’ve been teetering between “I’ll try” and “I’m in,” this episode is exactly what you need.----------For full show notes, please see: https://innatopiler.com/podcasts/simplify-hashimotos-healing-inna-topiler/Get ThyroLove - the first all in one bottle multi-nutrient comprehensive formula designed specifically for those with Hashimoto’s at ThyroLove.com - use code “Podcast” to get 10% off and free shipping For more information about everything Hashimoto’s please visit InnaTopiler.comIf you are struggling to lose weight with Hashimoto’s, Inna has a 10 day plan just for you at InnaTopiler.com/jumpstartIf you don’t yet know your thyroid type, please be sure you sign up for Inna’s next free training at InnaTopiler.com/zoomcall

17 Apr 18min

188 My Long Road to Healing Hashimoto’s and The New Shortcut with Inna Topiler

188 My Long Road to Healing Hashimoto’s and The New Shortcut with Inna Topiler

In this heartfelt solo episode of Thyroid Mystery Solved, Inna shares the personal story she’s never fully told on the podcast. From the confusing early symptoms to the years of trial and error, she opens up about what it really took to begin feeling like herself again.You’ll hear about the many paths she explored, the moments of deep frustration, and the breakthroughs that came from digging into the research and listening to her own body. Inna also reveals how her experience led her to something new. Something she wished she had from the very beginning. The creation of the first, all in one bottle, multi nutrient formula specifically for those with Hashimoto’s. She dives into the creation process, the research and all the behind-the-scenes of this supportive daily formula she created after years of piecing together supplements for herself and her clients. She explains how this approach came together, what makes it different, and how it can help fill the gaps for those navigating thyroid challenges.If you’ve ever felt lost in the process, or like no one really gets what you're going through, this conversation will make you feel seen—and offer a new perspective (and shortcut) to support your own healing journey.----------For full show notes, please see https://innatopiler.com/podcasts/healing-hashimotos-shortcut-inna-topiler/Get ThyroLove - the first all in one bottle multi-nutrient comprehensive formula designed specifically for those with Hashimoto’s at ThyroLove.com - use code “Podcast” to get 10% off and free shipping For more information about everything Hashimoto’s please visit InnaTopiler.comIf you are struggling to lose weight with Hashimoto’s, Inna has a 10 day plan just for you at InnaTopiler.com/jumpstartIf you don’t yet know your thyroid type, please be sure you sign up for Inna’s next free training at InnaTopiler.com/training

3 Apr 43min

187 Doctors Dismissing Hashimoto's Symptoms? Medical Gaslighting Explained with Dr. Efrat Lamandre

187 Doctors Dismissing Hashimoto's Symptoms? Medical Gaslighting Explained with Dr. Efrat Lamandre

Many people with Hashimoto’s have experienced it—the frustration of knowing something is wrong but being repeatedly dismissed by doctors. This week, Inna welcomes Dr. Efrat Lamandre (Dr. E) to uncover why so many thyroid patients struggle to get answers and how medical gaslighting keeps them stuck in a cycle of misdiagnosis and neglect.Dr. E, a best-selling author and expert in patient advocacy, explains why conventional medicine often overlooks key thyroid issues. She shares how doctors are trained to rely on a limited set of tools, without digging deeper. When those tests come back “normal,” patients are told their symptoms aren’t real or that their fatigue, weight gain, and brain fog must be due to stress or aging. But the reality? Hashimoto’s and thyroid dysfunction go far beyond TSH, and without the right tests, people can go undiagnosed for years.Inna and Dr. E dive into the most common signs of medical gaslighting and why it happens, from unnecessary weight loss advice to outright dismissal of symptoms. They also reveal why conventional providers often refuse to run crucial tests. Heather’s story, a real-life case from Inna’s Thyroid Mystery Solved program illustrates how damaging this dismissal can be and why proper testing and advocacy make all the difference.Beyond lab tests, Dr. E emphasizes an often-overlooked key to healing: nervous system regulation. Before addressing diet, supplements, or detox, the body needs to feel safe, something many Hashimoto’s patients don’t even realize is missing. She shares simple yet powerful ways to support the nervous system that anyone can do right away.If you’ve ever felt dismissed by your doctor or wondered why your symptoms aren’t taken seriously, this episode will open your eyes to the truth about thyroid care—and, more importantly, empower you with the knowledge to take control of your health.See full show here:https://innatopiler.com/podcasts/doctors-dismissing-hashimotos-symptoms-medical-gaslighting/For more information about everything Hashimoto’s please visit InnaTopiler.comIf you are struggling to lose weight with Hashimoto’s, Inna has a 10 day plan just for you at InnaTopiler.com/jumpstartIf you don’t yet know your thyroid type, please be sure you sign up for Inna’s next free training at InnaTopiler.com/training

20 Mars 47min

186 Over-Detoxing & Hashimoto’s: How to Support Your Liver & Adrenals with Dr. Izabella Wentz

186 Over-Detoxing & Hashimoto’s: How to Support Your Liver & Adrenals with Dr. Izabella Wentz

In this episode of Thyroid Mystery Solved, Inna welcomes Dr. Izabella Wentz—bestselling author and renowned thyroid advocate—to address a hidden pitfall affecting people with Hashimoto’s: the consequences of detox done too aggressively and its effects on the body and the adrenal glands.. She uncovers a recent case where overzealous cleansing tactics overwhelmed the liver, stalled adrenal function, and sparked worse symptoms instead of relief. They also examine how blocked elimination pathways can keep toxins recirculating, forcing the liver to work overtime and placing extra strain on cortisol production.Dr. Izabella and Inna investigate detox pathways and adrenals and show you how and why gentle methods that keep toxins moving out smoothly are so crucial, and how stress can derail healing even when the best of intentions are at play. You will see the strategies that work better for Hashimoto’s and thyroid issues and things you can do to help your body detox and support your adrenals. Tune in to learn practical tactics that turned a frustrating backslide into a powerful comeback. If you or someone you know has felt stuck despite multiple cleansing attempts, this discussion could be the key to solving that thyroid mystery.For full show notes:https://innatopiler.com/podcasts/detoxing-hashimotos-liver-adrenals-dr-izabella-wentz/For more information about everything Hashimoto’s please visit www.InnaTopiler.comIf you are struggling to lose weight with Hashimoto’s, Inna has a 10 day plan just for you at www.InnaTopiler.com/jumpstartIf you don’t yet know your thyroid type, please be sure you sign up for Inna’s next free training at www.InnaTopiler.com/training

6 Mars 54min

185 The Overlooked Link Between Estrogen and Hashimoto’s with Dr. Felice Gersh

185 The Overlooked Link Between Estrogen and Hashimoto’s with Dr. Felice Gersh

Most people don’t realize that estrogen is a powerful immune modulator—and when it comes to Hashimoto’s, its role is much bigger many realize. So many talk about “estrogen dominance” but there is way way more to this story, especially if we are over 35. While many conversations around estrogen focus on whether levels are too high or too low, the real question is how estrogen influences the immune system and thyroid function.In this episode, I sit down with Dr. Felice Gersh, a world-renowned expert in hormone health, to unravel the connection between estrogen and Hashimoto’s. And the truth is astounding—this link is rarely talked about, yet it plays a massive role in why so many women struggle with thyroid issues. We dive into how estrogen directly impacts immune function, thyroid health, and metabolism—far beyond the simplified idea of just balancing hormones. Dr. Gersh explains how estrogen shifts at different life stages, why women with Hashimoto’s often struggle with fluctuations, and what symptoms could signal an imbalance.We also explore why women are far more prone to Hashimoto’s than men, and how estrogen plays a direct role in triggering and regulating autoimmunity. Dr. Gersh shares how changes in estrogen—whether from birth control, pregnancy, perimenopause, or menopause—can create the perfect storm for thyroid dysfunction. Most importantly, we discuss what women can do to support their hormones naturally, from key nutrients and lifestyle shifts to the right kind of hormone testing and, in some cases, targeted hormone therapy done in a very specific and supplemental way.This is one of those episodes that will completely change how you think about your hormones and your thyroid. So many women have never heard this before, and it’s information that could make all the difference. Don’t miss this conversation—tune in now and find out what you need to know.Find the full show notes here: https://innatopiler.com/podcasts/link-between-estrogen-hashimotos-dr-felice-gersh/For everything Thyroid and Hashimoto’s please visit Inna at www.InnaTopiler.comIf you are struggling with weight gain please check out our 10 day Hashimoto’s Weight Loss Transformation www.InnaTopiler.com/jumpstart

20 Feb 1h 17min

184 The Hidden Ingredients Worsening Your Thyroid Symptoms with Jen Smiley

184 The Hidden Ingredients Worsening Your Thyroid Symptoms with Jen Smiley

If you’ve been doing everything right—going gluten-free, taking the right supplements, and following all the advice—but still struggling with fatigue, stubborn weight gain, or hair thinning… It's time to look beyond the obvious.In this episode, Inna sits down with Jen Smiley, founder of Wake Up and Read the Labels, to uncover the hidden ingredients lurking in so-called “healthy” foods that could be sabotaging your thyroid health. They break down why many gluten-free and packaged foods still contribute to inflammation, how sneaky additives like maltodextrin and “natural flavors” impact your gut, and the surprising places toxic Forever Chemicals (PFAS) are hiding in everyday foods and drinks.Plus, you’ll hear how Carol, a Hashimoto’s client in Thyroid Mystery Solved, turned things around by making simple swaps that finally helped her body respond—losing weight, restoring her energy, and even regrowing her hair.Press play now for really simple and actionable ways to make clean swaps that can make all the difference. Full Show notes: https://innatopiler.com/podcasts/hidden-food-ingredients-worsening-thyroid-symptoms-jen-smiley/ Please be sure you follow Inna on Instagram for everything Hashimoto’s www.instagram.com/innatopilerMore at: https://innatopiler.com/

6 Feb 41min

183 How the 10X Principle and the 80/20 Rule Can Transform Your Thyroid with Ina Coveney

183 How the 10X Principle and the 80/20 Rule Can Transform Your Thyroid with Ina Coveney

In this episode, Inna explores how two innovative business strategies—the 10X Principle and the 80/20 Rule—can revolutionize the way individuals approach Hashimoto’s and thyroid health. If you are feeling overwhelmed by conflicting advice or frustrated with their lack of progress this episode is for you.Inna shares the story of her client, Tricia, who was struggling to see results despite trying countless diets, intense workouts, and multiple protocols. Together, they shifted focus by setting a bold health goal, not just a little one and by applying these principles, Tricia was able to lose over 25 pounds and regain her energy.Joined by Ina Coveney, a business coach and host of the Superhuman’s Podcast, Inna and Ina (I know, almost name twins) delve into how these transformative strategies—typically used in business—can be applied to health for a real transformation. They discuss how aiming for bigger, more impactful goals helps to break free from ineffective habits and encourages a fresh perspective.You will see how you can simplify your wellness journey, focus on what truly drives results, and create a plan that fits your unique needs. It’s a new way of thinking about what you want for your thyroid and your health and how to get there way faster.Full Show notes: https://innatopiler.com/podcasts/thyroid-weight-loss-ina-coveney/Please be sure you follow Inna in Instagram for everything Hashimoto’s www.instagram.com/innatopilerIf weight loss is a struggle, please check out Inna’s 10 Day Hashimoto’s Weight Loss Transformation www.innatopiler.com/jumpstart - a weight loss plan specifically or hashimoto’s that is simple, effective and super affordable.

23 Jan 52min

182 Health Planning for 2025 - Inna's 6 Essential Steps to Thrive with Hashimoto's

182 Health Planning for 2025 - Inna's 6 Essential Steps to Thrive with Hashimoto's

In this episode, Inna offers a fresh perspective on health planning for 2025, focusing specifically on how you, with Hashimoto’s can set yourself up for success in a way that works with your unique needs. While everyone else is talking about business goals and career strategies, Inna takes a deeper dive into health planning—and more specifically, thyroid health planning.. For those living with Hashimoto's, traditional health planning often doesn’t quite cut it, which is why Inna shares her approach to creating a plan that’s not only achievable but sustainable for the long term.Inna walks you through the importance of identifying non-negotiables in your health routines—things like sleep, movement, and self-care that must come first in order to maintain energy and balance throughout the year. She gives personal examples from her own life that helps her manage her symptoms. Through the Big Rock analogy, she explains how putting these health priorities first—just like placing the big rocks in a glass—ensures that everything else will fit in around them, including the smaller, less important tasks.But what truly sets this episode apart is how Inna encourages you to think differently about planning. Rather than viewing it as something rigid or limiting, she explains how thoughtful, intentional planning can create freedom. By focusing on the bigger picture—your health goals and your thyroid's needs—you can avoid feeling overwhelmed or burnt out and stay on track. With actionable steps for breaking down big goals into manageable daily habits, this episode offers a practical blueprint for integrating health into every part of life, without compromising your wellbeing.If you're tired of generic health advice that doesn’t take your thyroid issues into account, this episode is for you. Inna’s relatable, step-by-step approach offers real solutions that are designed for those with Hashimoto’s, and she’ll inspire you to create a plan that not only fits your lifestyle but helps you thrive. And if weight loss is a part of your 2025 health goals, make sure to check out Inna’s 10-Day Hashimoto’s Weight Loss Transformation for a step-by-step guide to losing weight in a way that’s tailored to your thyroid. Tune in to discover why this year can be your healthiest one yet—and how, with the right mindset and planning, you can make 2025 the year your health finally works for you. Full show notes at: https://innatopiler.com/podcasts/health-planning-2025-thrive-hashimotos/For everything Hashimoto’s please visit www.InnaTopiler.com

9 Jan 30min

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