144 The Case of Premature Aging: How Lifestyle Changes and DNA Methylation Lead to Big Breakthrough with Dr. Kara Fitzgerald

144 The Case of Premature Aging: How Lifestyle Changes and DNA Methylation Lead to Big Breakthrough with Dr. Kara Fitzgerald

The Case:

  • Laura has thyroid issues causing her to feel overweight and her constantly dry skin made her feel like she was aging too fast.
  • She suspected that her issues might be genetic so she did a DNA test which revealed that she had the MTHFR gene.
  • She tried biohacking; taking high doses of B vitamins and a cocktail of other supplements but nothing got her the results she was looking for.

Investigation
My suspicions were that her various supplements might not be right for her. I also wanted to take a closer look at her diet and lifestyle.
Because I suspected that the answers were going to be found at the intersection of genetics, diet, and lifestyle I knew that Dr. Kara Fitzgerald would be the perfect person to consult with since she is an expert in epigenetics, nutrition, and aging. She is the author of two incredible books, Younger You: Reduce Your Bio Age and Live Longer, Better and Better Broths & Healing Tonics: 75 Bone Broth and Vegetarian Broth-Based Recipes for Everyone.
Unveiling the Power of Epigenetics
We often associate our health, thyroid function, and immune system with genetics and autoimmunity. However, as Dr. Kara explains, it is not our genes alone that determine our level of health, immune system function, or even our age. Instead, it is our epigenetics that play a significant role. I know there's a lot of confusion surrounding this topic, and in this episode, Dr. Kara shed some light on it.
She explains that in the early 2000s, scientists successfully deciphered the human genome. They discovered that we possess a little over 23,000 genes, and many believed that this knowledge would provide a clear roadmap to understanding and treating diseases. However, the reality turned out to be quite different. In over 90% of cases, genes alone do not determine our health outcomes. For most of us, the key lies in how our genes are being turned on and off—a fascinating field known as epigenetics that we’ve covered before in episode 143.
Unleashing the Potential of Epigenetic Expression
Epigenetics emerged as a prominent field of study after the completion of the Human Genome Project. It explores the factors that influence gene expression, such as our diet, exposure to toxins, stress levels, social connections, and exercise habits. Simply put, we have the power to determine which genes are activated and which ones remain dormant. Ideally, we want to activate the genes associated with health, longevity, and overall well-being while silencing those that contribute to disease progression.
This realization is particularly empowering for individuals like Laura, who believed that her family history of Hashimoto's meant she was destined to follow the same path. However, epigenetics shows us that we are not bound by our genetic heritage alone.
Lifestyle and Nutrition: The Epigenetic Keys
Dr. Kara dives into the exciting realm of lifestyle and nutrition, revealing some of the most significant factors that influence gene expression. Understanding these keys can help us unlock the potential for anti-aging, detoxification, and disease prevention.
1. Diet Program: Dr. Kara shares insights from a groundbreaking study on biological aging, which focused on DNA methylation—a marker of aging and gene expression changes. The study participants followed a specific diet program designed to optimize gene expression. The key elements of this diet program include:

  • Veggies and Greens: Emphasizing a plant-rich diet with an abundance of greens and cruciferous vegetables, cooked to support thyroid health.
  • Low-Glycemic and Fruit-Dense: Opting for low-glycemic vegetables and incorporating dark berries rich in polyphenols.
  • Smart Protein Choices: Eggs and liver (if open to consuming them) are excellent gene whispering foods, while seeds, nuts, and fatty fish provide essential nutrients.
  • Healthy Oils: Including extra virgin olive oil and coconut oil in cooking.
  • Vitamin D and Mushrooms: Ensuring sufficient vitamin D intake and recognizing the gene-regulating properties of mushrooms, such as shiitake and maitake.

2. Herbs and Spices: Dr. Kara highlights the impact of polyphenols found in various herbs and spices. Rosemary, thyme, oregano, curcumin, turmeric, quercetin, and resveratrol are just a few examples of potent gene regulators.

It's important to note that while we may inherit some gene expression patterns from our parents and ancestors, we still hold the reins and have the power to influence our health destiny. Understanding this gives us the opportunity to make informed choices and take control of our well-being.

Dr. Kara emphasizes the vital connection between epigenetics, aging, and thyroid disease. Aging acts as a primary driver for various chronic conditions, including hypothyroidism, Graves' disease, and subclinical hypothyroidism. Exploring the changes in epigenetic expression and DNA methylation provides valuable insights into the underlying mechanisms of these conditions. Epigenetic Lifestyle: A Holistic Approach to Optimal Health

Dr. Kara uses her study and others as examples to showcase that it's not just about individual foods but a synergistic combination that maximizes the effects on gene expression. She explains that her program incorporates low glycemic choices, intermittent fasting, exercise, and other crucial lifestyle factors. The Power of Simple Lifestyle Changes

Dr. Kara says the key to success is by making simple, doable lifestyle changes to improve our health and slow down the aging process. She emphasizes that the goal is not to engage in extreme measures but rather to focus on sustainable habits that can positively impact our overall well-being. That was the motivation behind her research team’s design of a program called "Younger You" that aimed to create meaningful changes in participants' health. The program included a simple exercise prescription, prioritized quality sleep, incorporated basic meditation practices, and recommended the use of a greens powder and probiotic supplement.

The results she shared were truly astonishing to me. Understanding the Role of DNA Methylation

DNA methylation plays a crucial role in gene expression and epigenetics. We’ve talked about this before (on this episode about the MTHFR gene) but it’s important to go beyond that. Methylation is involved in numerous essential processes in the body, from metabolizing hormones and neurotransmitters to maintaining optimal cell function. Methylation is influenced by various factors, including nutrients, gut health, and the microbiome.

Comprehensive testing is needed to assess methylation status and overall metabolic function. This involves looking at biomarkers such as homocysteine and methylation cycle intermediates. A functional medicine approach goes beyond the methylation cycle and explores other metabolic aspects, including gut health and individual nutrient needs. By understanding each person's unique metabolic profile, personalized interventions can be implemented to o...

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181 The Truth About Coffee and Autoimmune Health with Dr. Vincent Pedre

181 The Truth About Coffee and Autoimmune Health with Dr. Vincent Pedre

In this episode, Inna Topiler is joined by gut health expert Dr. Vincent Pedre to explore the hidden connections between coffee, fatigue, and Hashimoto’s.They dive into Samantha’s story—a busy mom of three who relied on coffee to power through her day but found herself trapped in an exhausting cycle of energy crashes. Inna and Dr. Pedre uncover surprising truths about coffee, including hidden toxins like mold, pesticides, and heavy metals, and how these can impact thyroid function, gut health, and overall energy and exactly what you can do to help this.They also discuss how caffeine affects slow metabolizers, the link between coffee and adrenal stress, and practical steps for enjoying coffee in a way that supports your health. Yes you can still enjoy your coffee if done the right way.Tune in now to learn how Samantha regained her energy—without giving up coffee completely!You can find the full show notes here:https://innatopiler.com/podcasts/coffee-autoimmune-health-dr-vincent-pedre/For everything Hashimoto’s please visit www.InnaTopiler.comIf you struggle with losing weight with Hashimoto’s - This is for you www.InnaTopiler.com/jumpstartBe sure you are following Inna on Instagram - www.instagram.com/innatopiler for all the latest Hashimoto’s help and support.

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180 When Food Isn’t Medicine: Thyroid and Hormone Truths with Emily Sadri

180 When Food Isn’t Medicine: Thyroid and Hormone Truths with Emily Sadri

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179 How Meditation Transforms Sleep and Reduces Stress for Hashimoto’s with Emily Fletcher

179 How Meditation Transforms Sleep and Reduces Stress for Hashimoto’s with Emily Fletcher

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178 The Truth About Losing Weight with Hashimoto’s and Hypothyroidism

178 The Truth About Losing Weight with Hashimoto’s and Hypothyroidism

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14 Nov 202420min

177 Health Transformation with Thyroid, Pain, Fatigue, and Beyond with Beth Mosher

177 Health Transformation with Thyroid, Pain, Fatigue, and Beyond with Beth Mosher

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176 Is Self-Sabotage Causing Your Weight Gain and Fatigue? How to Get Over It with Elyssa Smith

176 Is Self-Sabotage Causing Your Weight Gain and Fatigue? How to Get Over It with Elyssa Smith

What Causes Weight Gain and Fatigue Even When You Have a Healthy Lifestyle?Jump to the FULL SHOW NOTES HERE for all the linksThe Case: Dana is post-menopausal and experiencing weight gain, fatigue, and a general sense of not feeling well.She feels like she’s doing everything right: eating well, working out, and taking supplements, yet nothing is working.Along with her physical symptoms, Dana struggles with stress, anxiety, and feelings of overwhelming.Addressing More Than Just the ThyroidTo dig deeper into Dana’s health mystery, I invited Elyssa Smith, a trauma-informed life strategist and highly regarded speaker, onto the podcast. Elyssa specializes in helping people overcome trauma and self-sabotage so they can live their best lives. Her perspective was invaluable in addressing the mind-body connection, particularly how trauma can impact our health.Elyssa shared insights into how trauma—both big and small—can contribute to chronic health issues like those Dana was facing. While Dana's biochemical factors such as her thyroid levels, diet, and exercise regimen were important, Elyssa explained that trauma could still keep her body stuck in a state of fight-or-flight, preventing healing.Press Play to find out if trauma might be at the root of your inability to lose weight.Find out more about Inna here:  https://innatopiler.com/podcast/

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175 Perimenopause and Hashimoto’s + My Personal Hormone Journey

175 Perimenopause and Hashimoto’s + My Personal Hormone Journey

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174 A Tick Bite, Lyme Disease, and the Hashimoto's Connection with Dr. Darin Ingles

174 A Tick Bite, Lyme Disease, and the Hashimoto's Connection with Dr. Darin Ingles

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