Podcast #287: Sepsis Bundles

Podcast #287: Sepsis Bundles

Author: Aaron Lessen, M.D.

Educational Pearls

  • Treatment "bundles" are a popular approach to the rapid resuscitation of septic patients. A recent study in New York, where sepsis bundles are mandatory, sought to figure out which aspects of the bundle had impacts on mortality.
  • In a study of 40,000 septic patients, the study found that early antibiotics were associated with better outcomes, while early IV fluids were not associated with better outcomes.
  • This study affirms the important role of early antibiotics in sepsis. IV fluids may play an important role in the treatment of sepsis in some patients, but its role is less clear than antibiotics.

References: Time to Treatment and Mortality during Mandated Emergency Care for Sepsis Christopher W. Seymour, M.D., Foster Gesten, M.D., Hallie C. Prescott, M.D., Marcus E. Friedrich, M.D., Theodore J. Iwashyna, M.D., Ph.D., Gary S. Phillips, M.A.S., Stanley Lemeshow, Ph.D., Tiffany Osborn, M.D., M.P.H., Kathleen M. Terry, Ph.D., and Mitchell M. Levy, M.D. N Engl J Med 2017; 376:2235-2244 June 8, 2017 DOI: 10.1056/NEJMoa1703058

Avsnitt(1147)

Podcast 732: Organophosphate Toxicity

Podcast 732: Organophosphate Toxicity

Educational Pearls: Organophosphates affect the cholinergic system by inhibiting acetylcholinesterase affecting muscarinic and nicotinic receptors Symptoms include lacrimation, salivation, bronchocon...

23 Nov 20215min

Podcast 731: Fluid Resuscitation in Burns

Podcast 731: Fluid Resuscitation in Burns

Contributor: Chris Holmes, MD Educational Pearls: Parkland Formula: 4 mL x [Total Body Surface Area Burned (%)] x [body weight (kg)] given in 24 hours 50% given over 8 hours and 50% given over the ...

22 Nov 20214min

Podcast 730: Alternative Treatment for Gonorrhea

Podcast 730: Alternative Treatment for Gonorrhea

Educational Pearls: Recent updates to treatment guidelines increased the 250 mg ceftriaxone IM dose to 500 mg ceftriaxone IM IM dosing can be very painful, so other methods of administration can help...

16 Nov 20213min

Podcast 729: Molnupiravir for COVID

Podcast 729: Molnupiravir for COVID

Contributor: Jared Scott, MD Educational Pearls: A press release from Merck introduced Molnupiravir for treatment of mild to moderate COVID-19 The yet to be published study is a randomized control tr...

15 Nov 20215min

Podcast 728: Angiography for Out-of-Hospital Cardiac Arrest without ST Elevation

Podcast 728: Angiography for Out-of-Hospital Cardiac Arrest without ST Elevation

Contributor: Nick Tsipis, MD Educational Pearls: Meaningful survival under 10% for out of hospital cardiac arrest The most common cause of out-of-hospital cardiac arrest is due to cardiac ischemia St...

9 Nov 20215min

Podcast 727: Antibiotics for Diverticulitis

Podcast 727: Antibiotics for Diverticulitis

Contributor: Aaron Lessen, MD Educational Pearls: Classically, diverticulitis is diagnosed via CT scan and patients are discharged home on antibiotics if they are without complication The DINAMO stud...

8 Nov 20213min

Podcast 726: Ophthalmia Neonatorum

Podcast 726: Ophthalmia Neonatorum

Contributor: Peter Bakes, MD Educational Pearls: Ophthalmia Neonatorum encompasses any conjunctivitis that presents within the first 28 days of life Neonates often receive prophylactic silver nitrate...

2 Nov 20214min

Podcast 725: Hypothermia in Preterm Deliveries

Podcast 725: Hypothermia in Preterm Deliveries

Contributor: Aaron Lessen, MD Educational Pearls: Preterm deliveries in the ED can be complex and preventing hypothermia is essential to the health of the baby Recent meta-analysis examined methods f...

1 Nov 20213min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
svd-nyhetsartiklar
allt-du-velat-veta
medicinvetarna
rss-ufo-bortom-rimligt-tvivel
kapitalet-en-podd-om-ekonomi
rss-experimentet
rss-vetenskapsradion-2
sexet
rss-vetenskapsradion
hacka-livet
det-morka-psyket
dumforklarat
rss-spraket
pojkmottagningen
rss-arkeologi-historia-podden-som-graver-i-vart-kulturlandskap
4health-med-anna-sparre
halsorevolutionen
rss-personlighetspodden