Podcast 529: Hemophilia

Podcast 529: Hemophilia

Contributor: Aaron Lessen, MD

Educational Pearls:

  • Hemophilia is characterized by bleeding (A /B) A is is 8, B (chrstmas, 9)
  • Hemophilia refers to a group of bleeding disorders caused by a deficiency in a certain clotting factor. The two most common are hemophilia A (caused by a lack of factor VIII), and B (caused by a lack of factor 9)
  • Most cases are inherited in an X-linked recessive manner. Therefore, males are the most commonly affected. However, spontaneous cases do occur in all sexes.
  • People with hemophilia can present to the ED with a variety of bleeding complications including hemarthrosis, intracranial hemorrhage, and GI bleeds.
  • Treatment is guided by the type of hemophilia and the degree of bleeding, with the most severe cases being treated with replacement of 100% of that person's deficient clotting factor.
  • Timely treatment improves outcomes, so consider empiric therapy in those with known hemophilia

References

Hemophilia A in the third millennium.Franchini M, Mannucci PM Blood Rev. 2013 Jul;27(4):179-84. Epub 2013 Jun 28.

Rheumatic manifestations of hematologic disorders.Aviña-Zubieta JA, Galindo-Rodriguez G, Lavalle C Curr Opin Rheumatol. 1998;10(1):86.

The molecular genetics of hemophilia: blood clotting factors VIII and IX.Lawn RM Cell. 1985;42(2):405.

Guidelines for the management of hemophilia.Srivastava A, Brewer AK, Mauser-Bunschoten EP, Key NS, Kitchen S, Llinas A, Ludlam CA, Mahlangu JN, Mulder K, Poon MC, Street A, Treatment Guidelines Working Group on Behalf of The World Federation Of Hemophilia Haemophilia. 2013 Jan;19(1):e1-47. Epub 2012 Jul 6.

Summarized by Will Dewispelaere, MS4 | Edited by Erik Verzemnieks, MD

Avsnitt(1146)

Podcast 781: Foxglove, Dropsy, and Salvador Dali

Podcast 781: Foxglove, Dropsy, and Salvador Dali

Contributor: Chris Holmes, MD Educational Pearls: Foxglove plant contains the cardiac glycoside digoxin Foxglove leaf potions were once used to treat Dropsy; a historic term for symptoms of heart f...

16 Maj 20224min

Podcast 780: Pediatric Sedation Post-Intubation

Podcast 780: Pediatric Sedation Post-Intubation

Contributor: Aaron Lessen, MD Educational Pearls: Recent study looking at a pediatric emergency department to determine what percentage of patients after intubation received sedation within 10 minute...

10 Maj 20223min

Podcast 779: Pulse Pressure in Trauma

Podcast 779: Pulse Pressure in Trauma

Contributor: Aaron Lessen, MD Educational Pearls: Pulse pressure is the difference between the systolic and diastolic blood pressure, normal is about 40 A narrow pulse pressure is generally thought o...

9 Maj 20223min

Podcast 778: tPA for Frostbite Injury

Podcast 778: tPA for Frostbite Injury

Contributor: Peter Bakes, MD Educational Pearls: Mild frostbite injury usually only requires supportive care In severe frostbite injury, patients should receive an immediate angiogram, be admitted, a...

3 Maj 20223min

Podcast 777: Grass, Weed, and Ancient Rome

Podcast 777: Grass, Weed, and Ancient Rome

Contributor: Chris Holmes, MD Educational Pearls: Antiemetics were used in ancient Rome to help with sea-sickness and included toxic substances such as wine and wormwood and white hellborn The first ...

2 Maj 20225min

Mental Health Monthly #12: Management of Opioid Use Disorder with MAT (Medication-Assisted Treatment)

Mental Health Monthly #12: Management of Opioid Use Disorder with MAT (Medication-Assisted Treatment)

In this special episode of MHM, we feature Dr. Nadia Haddad, a Colorado psychiatrist, and Dr. Ricky Dhaliwal, an emergency medicine physician, as they discuss the implications of OUD in Colorado. As a...

27 Apr 202225min

Podcast 776: Single-Site Blood Cultures

Podcast 776: Single-Site Blood Cultures

Contributor: Aaron Lessen, MD Educational Pearls: Traditionally, blood cultures are drawn from two separate sites despite no data to suggest this is better than drawing blood from one site Recent stu...

26 Apr 20222min

Podcast 775: Olecranon Bursitis

Podcast 775: Olecranon Bursitis

Contributor: Aaron Lessen, MD Educational Pearls: Olecranon bursitis refers to inflammation in the bursa of the elbow and can be due to infection or trauma Recent study examined treating suspected se...

25 Apr 20223min

Populärt inom Vetenskap

dumma-manniskor
svd-nyhetsartiklar
p3-dystopia
allt-du-velat-veta
kapitalet-en-podd-om-ekonomi
det-morka-psyket
rss-ufo-bortom-rimligt-tvivel
rss-vetenskapsradion
pojkmottagningen
sexet
rss-vetenskapsradion-2
dumforklarat
rss-broccolipodden-en-podcast-som-inte-handlar-om-broccoli
medicinvetarna
halsorevolutionen
bildningspodden
rss-experimentet
rss-spraket
hacka-livet
vetenskapsradion