Permissive azotemia during AKI enables more rapid renal recovery and less renal fibrosis
ESICM Talk17 Maj 2023

Permissive azotemia during AKI enables more rapid renal recovery and less renal fibrosis

Preclinical models of acute kidney injury (AKI) consistently demonstrate that a uremic milieu enhances renal recovery and decreases kidney fibrosis.

Reduced renal clearance has the surprising and counterintuitive effect of being an effective treatment for AKI.

In this perspective, Dr Lakhmir S. Chawla suggests a hypothesis describing why the uremic milieu is kidney protective and proposes a clinical trial of ‘permissive azotemia’ to improve renal recovery and long-term renal outcomes in critically ill patients with severe AKI.

Hear more about the explanation of this hypothesis in the following podcast, organised by the ESICM AKI Section.

Speakers

Lakhmir S. CHAWLA. Chief Medical Officer, Silver Creek Pharmaceuticals. Recipient of the International Vicenza Award for Critical Care Nephrology.

Eric HOSTE. UZ Gent (BE). AKI Section Representative, ESICM Social Media & Digital Content Committee.

Marc ROMAIN. Hadassah Medical Center, Jerusalem (IL).

Avsnitt(91)

Artesunate treatment in severely injured patients with traumatic haemorrhage

Artesunate treatment in severely injured patients with traumatic haemorrhage

Multiple organ dysfunction syndrome (MODS) is common after major trauma, affecting up to two-thirds of patients with critical injuries. Post-trauma MODS is associated with a mortality of over 20% and ...

20 Sep 202318min

Life after sepsis in adult and paediatric patients

Life after sepsis in adult and paediatric patients

Sepsis is a life-threatening acute organ dysfunction secondary to infection and affects more than 19 million people annually. In 2017, it was estimated that almost 49 million people were infected by s...

13 Sep 202325min

Severe meningoencephalitis in the ICU: results from the EURECA study

Severe meningoencephalitis in the ICU: results from the EURECA study

Central nervous system (CNS) infections significantly burden ICU physicians' daily clinical work. Diagnosis can be challenging, and timely management is of the utmost importance. Meningoencephalitis i...

6 Sep 202318min

Diabetes mellitus in old critically ill COVID-19 patients

Diabetes mellitus in old critically ill COVID-19 patients

Several studies have found an association between diabetes mellitus, disease severity and outcome in COVID-19 patients. Old, critically ill patients are particularly at risk. A recent multicentre inte...

30 Aug 202310min

Results from the TAME trial

Results from the TAME trial

International guidelines recommend targeting normocapnia in adults with coma resuscitated after out-of-hospital cardiac arrest. However, normocapnia may be insufficient to restore and maintain adequat...

27 Juni 202325min

Guidelines for the management of severe community-acquired pneumonia

Guidelines for the management of severe community-acquired pneumonia

Severe community‐acquired pneumonia (sCAP) is a clinical entity to describe ICU-admitted patients with community‐acquired pneumonia (CAP) as they might require organ support, and it is associated with...

24 Maj 202320min

How to manage coagulopathies in critically ill patients

How to manage coagulopathies in critically ill patients

Coagulopathy is a severe and frequent complication in critically ill patients, for which the pathogenesis and presentation may be variable depending on the underlying disease. Therefore, a review has ...

10 Maj 202320min

Populärt inom Business & ekonomi

framgangspodden
varvet
badfluence
rss-jossan-nina
rss-borsens-finest
uppgang-och-fall
rss-svart-marknad
avanzapodden
rss-dagen-med-di
rss-kort-lang-analyspodden-fran-di
svd-tech-brief
fill-or-kill
lastbilspodden
borsmorgon
kapitalet-en-podd-om-ekonomi
bathina-en-podcast
rss-den-nya-ekonomin
rss-wallnor-pm
rss-inga-dumma-fragor-om-pengar
tabberaset