Spermidine – The Powerful AntiAging compound you’ve never heard of but is about to take the world by storm

Spermidine – The Powerful AntiAging compound you’ve never heard of but is about to take the world by storm

Primeadine
Spermidine – The Powerful AntiAging compound you’ve never heard of but that is about to take
the world by storm. In this episode I sit down with Leslie Kenny the CEO and Founder of
OxFord Healthspan – a company founded for the purpose of bringing powerful healthy/anti
aging compounds to market. Today we deep dive into their first entry which is rooted in
ancient knowledge and yet relatively new to the modern world. Consider that this compound
hits at least 5 of the 9 hallmarks of aging….even better, new research seems to point to its
ability to improve immune response in elderly adults by helping certain areas of the immune
system to reboot and rejuvenate!! Oxford Span is committed to making this
supplement available to as many people as possible – for the month of December you can
benefit from introductory pricing PLUS an additional 15% discount (BIONAT15 promo code). If
you are this after December 2020 the discount code will still work!!
Note that this supplement will produce most noticeable results in the 50+ crowd who are
already seeing a decline in endogenous spermidine production and is not appropriate for
people with celiac disease or severe wheat allergies – we talk about all this and more in the
episode….enjoy!!
6:08
Leslie’s story – from autoimmune disease & infertility to how she first came across spermidine
7:22
The link between ancient Japanese scrolls on longevity and sexual intimacy and spermidine
11:05
Compounds that target the 9 hallmarks of aging and the 5 specifically targeted by Spermidine
13:30
Dietary sources and the reason why supplement companies are having to extract spermidine
from wheat instead of Natto
15:30
Natto – possibly the best and most economical source of spermidine
17:33
Who should NOT use the current Spermidine supplements (including Primeadine) and why
18:02
Amount of gluten per serving vs a slice of
19:54
Why the 50+ crowd is likely to experience the best visible results from Primeadine
20:55

Endogenous and exogenous sources of spermidine
22:57
The physical signs that your spermidine production is declining
28:20
Short, medium and long term benefits
36:05
Maximum dose as determined by regulatory bodies
38:49
Getting back to the ancient Daoist Scrolls – the aging male’s advantage over women

45:29
Best time of day to take Primeadine
50:27
DO NOT mix with hot foods or beverages
52:25
Introductory pricing in place until December 31, 2020
15% discount code in place for December and the new year: BIONAT15
Website:
Primeadine.com or OxfordHealthSpan.com

Just a few of the growing list of studies assessing Spermidine’s possible benefits for human
and longevity
Studies/References
Effect on Hormones, Fertility in men and women
The regulatory effect of biogenic polyamines spermine and spermidine in men and women. Open
Journal of Endocrine and Metabolic Diseases, 9(03), 35
Spermidine Intake and Longevity in humans
Higher spermidine intake is linked to lower mortality: a prospective population-based study. The
American journal of clinical nutrition, 108(2), 371-380
The autophagy enhancer spermidine reverses arterial aging in aged mice. Mechanisms of ageing
and development, 134(7-8), 314-320.

Okamoto, A., Sugi, E., Koizumi, Y., Yanagida, F., & Udaka, S. (1997). Polyamine content of ordinary
foodstuffs and various fermented foods. Bioscience, biotechnology, and biochemistry, 61(9), 1582-
1584
Ramot, Y., Tiede, S., Bíró, T., Bakar, M. H. A., Sugawara, K., Philpott, M. P., ... & Paus, R. (2011).
Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell
functions. PLoS One, 6(7), e22564
Rinaldi, F., Marzani, B., Pinto, D., & Ramot, Y. (2017). A spermidine-based nutritional supplement
prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-
blind study. Dermatology Practical & Conceptual, 7(4), 17.
Schwarz, C., Horn, N., Benson, G., Calzado, I. W., Wurdack, K., Pechlaner, R., ... & Flöel, A. (2020).
Spermidine intake is associated with cortical thickness and hippocampal volume in older adults.
NeuroImage, 221, 117132
Dietary polyamine intake and colorectal cancer risk in postmenopausal women. The American
journal of clinical nutrition, 102(2), 411-419

And finally an article on new findings of the effects of Spermidine on immune function is elderly
humans:
https://www.longevity.technology/autophagy-in-t-cells-maintained-by-
spermidine/?utm_source=ZohoCampaigns

Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition before you make any changes.

Avsnitt(366)

#312 Age-Defying Bone Health: Preventing Osteoporosis with Science-Backed Interventions and Reversal Techniques You Can Try TODAY With Doug Lucas

#312 Age-Defying Bone Health: Preventing Osteoporosis with Science-Backed Interventions and Reversal Techniques You Can Try TODAY With Doug Lucas

Join me as I delve into the fascinating world of bone health with Dr. Doug Lucas, an orthopedic surgeon who has transitioned into a bone health expert. In this episode, we'll discuss why maintaining strong and flexible bones is crucial not only for the elderly but starting from a young age.   What We discuss: Doug Lucas discusses bone health and prevention ... 03:44 Doug Lucas's background in orthopedics ... 09:32 Importance of bone health from early adulthood ... 13:15 Impact of lifestyle on bone health ... 22:25 Nutritional considerations and gut health ... 28:28 Exercise's role in maintaining bone health … 40:20 Discussion on osteogenic loading technologies … 55:48 Importance of vibration plates and safety … 01:07:48 Role of supplements in bone health … 01:14:55 Dr. Doug Lucas's resources and community … 01:23:38   Our Amazing Sponsors: JJ Virgin -  Listen to Well Beyond 40 If you're ready to take control of your health and feel your best at any age, head to followjjvirgin.com   BEAM Minerals - This Liquid Formula delivers the perfect mix of all the sleep supporting minerals you need. Visit beamminerals.com and use code NAT20 to get 20% off your order.   LVLUP: The secret to CREvolution? It’s all about GAA. This powerful compound helps you get more creatine into your cells faster than traditional creatine. Ready to crush your next workout? Head to lvluphealth.com and use the code NAT for 15% off.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

25 Feb 1h 26min

#311: AGING REWIND: 4 Lifestyle Tweaks That Turn the Clock Back | With Nathalie Niddam

#311: AGING REWIND: 4 Lifestyle Tweaks That Turn the Clock Back | With Nathalie Niddam

On today’s episode, I'm doing something a bit different—stepping away from our usual discussions about peptides, supplements, and high-tech health solutions. Instead, I'm focusing on some of the most basic, yet crucial lifestyle habits that could accelerate your aging without you even realizing it.   What We discuss:  Concept of Accelerated Aging and Simple Lifestyle Shifts ... 00:00:34 Impact of Processed Foods and Smoking on Aging ... 00:01:00 Example of Centenarians and Factors Contributing to Longevity ... 00:03:30 Habit 1: Importance of Quality Sleep ... 00:06:45 Habit 2: Managing Chronic Stress ... 00:13:36 Habit 3: Sedentary Lifestyle and Over-Exercising ... 00:22:32 Habit 4: The Role of Loneliness and Social Connections ... 00:33:59 Potential Benefits of Owning a Pet ... 00:39:45   Our Amazing Sponsors: Just Thrive - 99% of probiotics on the market die in your stomach before they even reach your gut. Just Thrive is the only probiotic guaranteed to arrive 100% alive where you need it most. Visit JustThriveHealth.com and use code NAT20 for 20% off your first 90-day bottle.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

21 Feb 35min

#310: Mold MENACE: From Chronic Illness to Expert | Why Women Are More Vulnerable and How to Protect Your Home With PJ Harlow

#310: Mold MENACE: From Chronic Illness to Expert | Why Women Are More Vulnerable and How to Protect Your Home With PJ Harlow

Today we get to hear from PJ Harlow, a holistic mold consultant and healthy building pro, who shares her riveting journey from battling chronic illness caused by mold exposure in her own home to becoming an expert in mold remediation and consultation.   What We discuss: PJ Harlow's mold experience and family impact ... 00:09:14 Why women are more affected by mold ... 00:20:09 Kids' symptoms of mold exposure ... 00:26:51 Initial steps in mold assessment ... 00:29:46 Choosing a reliable mold inspector ... 00:34:43 Considering home features and environment ... 00:43:02 Remediation decisions and property impact ... 00:48:53 Usefulness of dehumidifiers and air filters ... 00:50:03 Probiotic products for the home ... 00:52:23 Genetic susceptibility to mold illnesses ... 00:56:36 Mold's financial and emotional impact ... 01:00:33 Navigating mold issues during home buying ... 01:08:27   Our Amazing Sponsor: Timeline - Improve your cellular energy, strengthen muscle, and boost endurance by taking Mitopure daily. Mitopure unlocks 6x more Urolithin A than diet alone. Visit timeline.com/nat10 for 10% off.    Puori - 21 grams of high-quality whey protein from pasture-raised cows with no hormones, GMOs, or pesticides. Ready to ditch the questionable protein powders? Visit Puori.com/NAT and use my code NAT to get 20% off your first order!   ProLon - Enjoy 5 days of nutrient-dense meals designed to mimic fasting without feeling deprived. You will feel AMAZING! Visit prolonlife.com/Nat to receive 20% off at checkout. If you’re in Canada you can go to Prolonfast.ca and use code NAT20 to save.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

18 Feb 1h 19min

#309: Cordycepin and Methylene Blue: Two Game-Changers For Better Energy, Focus, Sleep, and So Much More With Dr. Scott Sherr

#309: Cordycepin and Methylene Blue: Two Game-Changers For Better Energy, Focus, Sleep, and So Much More With Dr. Scott Sherr

Today we’re talking about methylene blue—aka the stuff that biohackers love, and journalists love to call "fish tank cleaner."  Discover how methylene blue functions as a redox cycling agent, enhancing mitochondrial function, supporting immune health, and even boosting mood.   What We discuss:  Focus on methylene blue and its benefits ... 00:04:33 Introduction to delivery systems and troches ... 00:09:00 Mitochondria's role in health ... 00:17:49 Methylene blue's impact on mitochondria ... 00:26:31 Dosage and its effects on different health issues ... 00:33:45 Cordycepin and immune support ... 00:50:39 GABAergic system and TroZ ... 01:00:59 Travel stack and recommendations ... 01:19:49 Closing thoughts and top tips for longevity ... 01:24:01   Our Amazing Sponsors: Profound Health - Nature’s Marvels have been making bioregulators for over a decade, working directly with Prof. Khavinson, the pioneer of Bioregulator science! They’re manufactured in the UK. They’re GMP and HACCP certified and FDA-compliant. Whatever your health needs, there’s a bioregulator for you. Head to profound-health.com and use code LONGEVITY15 for 15% off your first order.   LVLUP: The secret to CREvolution? It’s all about GAA. This powerful compound helps you get more creatine into your cells faster than traditional creatine. Ready to crush your next workout? Head to lvluphealth.com and use the code NAT for 15% off.   BiOptimizers - Magnesium Breakthrough: It’s the only full-spectrum magnesium supplement with 7 unique forms of magnesium that your body can actually use and absorb. Go to  bioptimizers.com/bionat and enter the coupon code BIONAT to get 10% off your order.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

14 Feb 1h 26min

#308: Destigmatizing Self-Pleasure: A Holistic Path to Sexual Optimization with Dr. Saida Désilets

#308: Destigmatizing Self-Pleasure: A Holistic Path to Sexual Optimization with Dr. Saida Désilets

In today's episode, we're joined by a remarkable guest, Dr. Saida Désilets, a body philosopher, psychologist, and sexuality expert who empowers people to reclaim their sexual sovereignty.    Together, we embark on an illuminating journey to explore the profound connection between sexuality and vitality as we age, addressing common limiting beliefs and introducing groundbreaking concepts like relaxed arousal and self-touch as essentials for enhancing overall well-being.    What We discuss: Dr. Saida's Background and Body Philosophy ... 00:06:24 The Importance of Sexuality for Longevity ... 00:07:53 Dr. Saida's Origin Story: Connection to Erotic Aliveness ... 00:09:32 Development of the Desilets Method ... 00:12:00 Challenges of Menopause and Reframing Aging ... 00:25:19 Breaking Negative Beliefs for Healthier Aging ... 00:28:58 Creating a Relationship with Self and Pleasure ... 00:32:22 The Concept of Relaxed Arousal ... 00:34:11 Destigmatizing Self Pleasure and Societal Impact ... 00:40:00 Dr. Saida on Oxytocin and Self-Touch ... 00:51:48 Vibrators versus Natural Stimulation ... 00:53:27 Postpartum Sexuality Challenges ... 01:00:26 Introduction to Inanna Women and Serum Benefits ... 01:07:28 Dr. Saida's Work in South Africa on Sexual Health ... 01:13:10   Our Amazing Sponsors: Manukora - Supports immunity and gut health with high levels of antioxidants and prebiotics and MGO powerful antimicrobial compounds. 70% of the antioxidants found in Manukora honey are not found in any other honey! Head to manukora.com/NATNIDDAM  to get $25 off the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travel sticks, a wooden spoon, and a guidebook!   Wizard Sciences (Neural Rx) - Neural Rx isn’t just about a quick boost. It’s designed to protect your brain long-term. With C60 (an antioxidant) and anti-inflammatory benefits, it combats oxidative stress and helps keep those brain cells healthy and happy. Plus, it supports mitochondrial efficiency, meaning more energy and focus for the long haul. Use code NAT15 at checkout to get 15% off your purchase. Visit wizardsciences.com.   Just Thrive - 99% of probiotics on the market die in your stomach before they even reach your gut. Just Thrive is the only probiotic guaranteed to arrive 100% alive where you need it most. Visit JustThriveHealth.com and use code NAT20 for 20% off your first 90 day bottle.   Nat’s links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

11 Feb 1h 22min

#307: Mold Toxicity, Gongs & Biohacking: A Journey of RESILIENCE with Sandy Martin

#307: Mold Toxicity, Gongs & Biohacking: A Journey of RESILIENCE with Sandy Martin

Today you get to hear from my new friend Sandy Martin. We'll hear about her journey from running massive events like GalaxyCon to battling frustrating symptoms that finally resulted in a diagnosis of mold toxicity.  You’ll hear more about Sandy’s amazing Biohacker Expo in the episode - she offered the listeners of this podcast a very generous discount of 50% off your ticket to the expo. Did I mention it’s in Miami? It runs from Feb 28th - March 1st. Head over to biohackerexpo.com and use code NAT50 for 50% off your ticket!   What We discuss: Sandy's background in running large events ... 00:05:19 Symptoms and struggles with mold toxicity ... 00:08:50 Misdiagnosis and functional medicine experiences ... 00:11:03 Realization of mold toxicity and steps taken ... 00:13:15 Importance of getting out of the moldy environment ... 00:22:11 Healing journey with sound healing and gongs ... 00:26:21 Finalizing diagnosis and moving forward ... 00:32:29 Personal transformation and relationship changes ... 00:34:58 Starting Biohacker Expo and event details ... 00:36:01 Unique aspects of the Biohacker Expo ... 00:47:07 Importance of sharing experiences and final thoughts ... 00:51:27 Event information and closing remarks ... 00:53:14   Our Amazing Sponsor: Young Goose Youth Reset - Whether you’re into instant results or the slow-burn science of looking incredible for decades, Youth Reset has you covered. Give your skin a little love, get your glow back, and let Young Goose remind you that ‘youthful’ isn’t an age—it’s an attitude. Now go check out Youth Reset and be the person people accuse of having ‘great genes.’ Younggoose.com NAT10 on your first order and 5NAT if you’re already a customer.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

7 Feb 54min

#306: The Untold Power of Bioregulators: Reversing Age and Chronic Illness With Dr. Kent Holtorf

#306: The Untold Power of Bioregulators: Reversing Age and Chronic Illness With Dr. Kent Holtorf

In today’s episode, Dr. Kent Holtorff and I cover an array of topics from the incredible potential of bioregulators in reversing aging and optimizing health, to innovative therapeutic strategies for complex health issues like hypothyroidism and chronic kidney disease. Dr. Holtorff shares some fascinating insights from his clinical practice, including his pioneering work with veterans suffering from PTSD and traumatic brain injury, where bioregulators and peptides have shown remarkable therapeutic benefits. You can also find a lot of the products we discuss in this episode at Integrativepeptides.com and as a listener of this podcast you get to use code NAT10 to save on anything in the store!   What We discuss: Dr. Kent Holtorff Background and Expertise ... 00:08:45 The Beginning of Peptide Interest ... 00:11:02 Early Use of Bioregulators in Germany ... 00:12:15 Transition from Peptides to Bioregulators ... 00:18:34 Relating Epithalamin and Epitalon ... 00:20:00 Introduction to New Bioregulators ... 00:23:17 Insight from Russian Literature ... 00:27:10 Thyroid Bioregulator Development ... 00:35:00   Our Amazing Sponsors: Puori - 21 grams of high-quality whey protein from pasture-raised cows with no hormones, GMOs, or pesticides. Ready to ditch the questionable protein powders? Visit Puori.com/NAT and use my code NAT to get 20% off your first order!    SiPhox - SiPhox is the only comprehensive at-home blood testing solution that lets you check up to 50 biomarkers from your home. No travel, no appointments, just a few drops of blood on a card and you're set. You'll get easy to understand insights and a clear plan of action to help optimize your health, all based on your unique results. Visit SiPhoxhealth.com forward slash nat and you get 20 % off your first order using code NAT.   Just Thrive - 99% of probiotics on the market die in your stomach before they even reach your gut. Just Thrive is the only probiotic guaranteed to arrive 100% alive where you need it most. Visit JustThriveHealth.com and use code NAT20 for 20% off your first 90 day bottle.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

4 Feb 1h 28min

#305: Navigating IBS, SIBO, and the Low FODMAP Diet: Expert Insights from Dr. Michael Ruscio

#305: Navigating IBS, SIBO, and the Low FODMAP Diet: Expert Insights from Dr. Michael Ruscio

Today’s guest is Dr. Michael Ruscio, a renowned naturopathic practitioner, who discusses the critical links between gut health, brain health, and overall well-being. They discuss new insights into IBS, revealing its reclassification as a gut-brain interaction disorder, and dive into different dietary strategies for managing gut issues, including low FODMAP, Candida, and low histamine diets. Dr. Ruscio offers expert advice on navigating common health concerns like gluten sensitivity, nutrient intake, and the effects of modern life on gut health. He emphasizes a step-wise, holistic approach to healing, underscoring the body's natural ability to restore balance. Tune in for practical insights on improving gut health and enhancing longevity through balanced nutrition and thoughtful dietary choices.   Exciting Announcements! This podcast can count for continuing education for nurses check out RNEGADE Pro for more info! Biohacker Expo - I’ll be speaking on the main stage at the Biohacker Expo in FL this month. Visit biohackerexpo.com and use code NAT50 for 50% off your ticket! I’ll see you there on Friday, Feb 28 on the MainStage at 11 am.   What We discuss: Functional Gastrointestinal Disorders (FGDS) ... 00:10:02 Gut and Mental Health Connection ... 00:11:00 Different Gut Types and Diets ... 00:12:45 Personalizing Diets for Gut Health ... 00:15:31 Hormones and Thyroid Issues ... 00:30:00 Red Light Therapy for Thyroid Health ... 00:39:00 The Role of Gluten in Gut Health ... 00:45:32 Impact of Location on Gluten Sensitivity ... 00:50:32 BPC-157 and Peptides in Gut Health ... 01:07:32 Seed Oils and Omega Balances ... 01:03:24 Podcast Wrap Up and Where to Find Dr. Ruscio ... 01:10:21   Our Amazing Sponsors: LVLUP CREvolution - The secret to CREvolution? It’s all about GAA. This powerful compound helps you get more creatine into your cells and faster than traditional creatine. Combine that with the absorption power of HBCD, and you’ve got a formula that’s built for serious results. Head to lvluphealth.com and use the code NAT for 15% off.   JJ Virgin -  Listen to Well Beyond 40 If you're ready to take control of your health and feel your best at any age, head to followjjvirgin.com   Timeline - Improve your cellular energy, strengthen muscle, and boost endurance by taking Mitopure daily. Mitopure unlocks 6x more Urolithin A than diet alone. Use code NAT10 for 10% off your order at timelinenutrition.com.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

31 Jan 1h 12min

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