Episode #279: Dr. Anurag Singh: Urolithin A, the Aging Immune System, Biological Age Reversal and more…

Are you protecting your immune system as you age? In this Longevity podcast episode, I am joined by Dr. Anurag Singh to discuss recent research that suggests Urolithin A, a compound derived from pomegranates and other foods, may help rejuvenate the aging immune system. We dive into how supplementing with Urolithin A for just 4 weeks led to significant improvements in immune cell function and a reduction in biological age by an average of 2 years in middle-aged adults. We also discuss insights on dosing, combining Urolithin A with other longevity strategies, and ongoing clinical trials that may reveal even more benefits. Dr. Anurag Singh is the Chief Medical Officer of Timeline Nutrition, a biotech company focused on discovering and developing next generation natural compounds that target improvement in mitochondrial health. He began his career in 2003 as a Resident Medical Doctor at Northern Railway Divisional Hospital in Lucknow. Go to TimelineNutrition.com/nat10 and/or use code Nat10 for a discount. Thank you to our sponsors for making this episode possible: Element Health: Use code Longevity when shopping at https://elementhealthsupply.com/discount/Longevity to save on your orders. Siphox: Visit http://SiPhoxhealth.com/nat and save on your test. Find more from Dr. Singh/Timeline: Website: www.timelinenutrition.com Instagram: @timeline_longevity Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Join Nat's Membership Community: https://www.natniddam.com/bsp-community Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0 Instagram: https://www.instagram.com/nathalieniddam/ Website: www.NatNiddam.com Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance What We Discuss: 09:04 The Role of the Immune System in Aging 12:10 Understanding Immune Exhaustion and Inflammation 15:12 Mitochondrial Health and Immune Function 18:06 Urolithin A: Sources and Production 12:05 Research Studies on Urolithin A and Cancer 30:01 Clinical Trials and Future Directions 31:17 Understanding the Immune System 33:54 The Mitoimmune Randomized Control Trial 38:31 Dosing and Effects of Urolithin A 40:22 Biological Age Reversal and Longevity 44:33 Combining Strategies for Enhanced Benefits 49:21 Future Research Directions in Cancer and Neurodegeneration Studies Mentioned: Mitochondrial Recycling Reverts Age-Associated Decline Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy Mitopure Impact on Immune Aging: RCT