a16z Podcast: Making the Case for Permissionless Innovation

The irony of our systems working so well -- technological, corporate, and yes, even political -- is that we've become too comfortable: matching to others just like us, producing less, taking fewer ris...

1 Mars 201737min

Humans have always wanted to enhance themselves -- from getting nutrition just-right to optimizing their performance, whether in sports or health or work. And food is a big part of all that. But our c...

28 Feb 201719min

Imagine, for a moment, an alternative universe: One where Netflix got disrupted by some other streaming-content company that made its DVD rental business irrelevant. But that's just a counterfactual. ...

26 Feb 201745min

Evolution and technology have allowed our human species to manipulate the physical environment around us -- reshaping fields into cities, redirecting rivers to irrigate farms, domesticating wild anima...

23 Feb 201744min

It's been nearly 15 years since the Human Genome Project was completed. But "are we there yet" in the golden age of genomics? What did we think we'd have by now, what do we actually have, and what do ...

22 Feb 201725min

The hardest thing about pivots (major shifts in company/product direction) isn't just the actual pivot. It's the courage to make the decision... and being honest with yourself as a CEO. Especially sin...

19 Feb 201732min

The modern enterprise holds all sorts of applications, devices, and workflow needs. How should we be thinking about securing infrastructure -- and identity -- in this context, for entities like major ...

14 Feb 201719min

Thanks to freeways, cities became something to get through instead of something to get to. Now, as the next transportation revolution -- from rivers to trains to cars to autonomous cars -- promises to...

8 Feb 201735min