Merel Kindt: How to Eliminate Phobias and PTSD Permanently

Merel Kindt: How to Eliminate Phobias and PTSD Permanently

Merel Kindt discusses how fear extinction can be achieved permanently, covering propranolol, epigenetics, psychedelics, and the broader implications of erasing fear. The conversation explores scientific approaches to phobias, PTSD, and future challenges in fear‑removal research.- 00:00 - Introduction to fear extinction- 14:07 - Propranolol and blood/brain barrier- 18:32 - Epigenetics and inherited fears- 26:33 - Removing fear of public speaking- 30:36 - PTSD- 33:45 - Psychedelics MDMA for self‑treatment- 37:29 - Pilot study with cigarette addiction- 42:31 - Should we get rid of fear? Consequences- 43:13 - MDMA vs LSD vs Psilocybin- 48:07 - Fear of silverfish- 50:13 - Modeling‑based phobias- 54:37 - Kindt 2009 paper on memory engrams- 55:34 - Kindt 2019 paper- 58:02 - Imagery scripting- 59:35 - Disgust removal?- 1:00:36 - How beta‑blockers work- 1:02:04 - Sleep for memory reconsolidation- 1:03:33 - Startle reflex measurement- 1:06:07 - Testing alternative beta‑blocker- 1:07:12 - Future challenges and limitationsSPONSORS:- Patreon: https://patreon.com/curtjaimungal- PayPal: https://bit.ly/2EOR0M4- Twitter: https://twitter.com/TOEwithCurt- Apple Podcasts: https://podcasts.apple.com/ca/podcast/better-left-unsaid-with-curt-jaimungal/id1521758802- Pandora: https://pdora.co/33b9lfP- Spotify: https://open.spotify.com/show/4gL14b92xAErofYQA7bU4e- Google Podcasts: https://play.google.com/music/listen?u=0#/ps/Id3k7k7mfzahfx2fjqmw3vufb44RESOURCES:- DOCUMENTARY SERIES: https://www.youtube.com/watch?v=pM3G6kITdYk- MEREL'S WEBSITE: https://kindtclinics.com/en/- http://betterleftunsaidfilm.com Theories of Everything with Curt Jaimungal features long-form, technically detailed interviews with leading researchers in physics, mathematics, consciousness, and philosophy, exploring topics at the level of active research. For academics, graduate students, and anyone seeking depth beyond popular science. SPONSOR: I subscribe to The Economist for their science and tech coverage. As a TOE listener, get 35% off! No other podcast has this: https://economist.com/TOE FOLLOW: Substack | Spotify | YouTube | Twitter Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices

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Jacob Barandes and Emily Adlam: Why Many Worlds Is Nonsensical

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Emily Adlam and Jacob Barandes deliver a forceful critique of the Many‑Worlds Interpretation, arguing that it remains a philosophical fantasy without testable predictions or empirical grounding. The c...

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Curt Jaimungal: What Is Energy, Actually?

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Curt Jaimungal challenges the conventional notion of energy, arguing it's not even a well-defined concept. He builds on Veritasium’s critique and explores the philosophical and scientific implications...

6 Juni 202512min

Eric Weinstein: The Theory He Kept Secret for Four Decades (Geometric Unity)

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Eric Weinstein reveals the core of his Geometric Unity theory after 40 years of development. He also explores philosophical implications, quantum‑classical relationships, and the challenges of communi...

3 Juni 20253h 10min

David Wallace: Why Many Worlds Is the Only Consistent Interpretation

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Philosopher of physics David Wallace unpacks the Everett (Many‑Worlds) interpretation, tackling common misconceptions, probability, emergence and personal identity across multiple worlds. He also exam...

29 Maj 20252h 18min

Yang-Hui He: How AI Is Reshaping Pure Mathematics Right Now

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Yang-Hui He explores how AI is reshaping pure mathematics, from the murmuration conjecture to Riemann Hypothesis. We examine the changing research landscape, the role of intuition, and what a future w...

23 Maj 20251h 59min

Curt Jaimungal: Explain Like I'm Five? Challenge Accepted.

Curt Jaimungal: Explain Like I'm Five? Challenge Accepted.

We examine the common claim that you must be able to explain a concept to a five‑year‑old to truly understand it, arguing that the idea can be misleading and even harmful. The episode explores why som...

15 Maj 202520min

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