Is Red Meat the Fountain of Youth? Paul Saladino : 1229

Is Red Meat the Fountain of Youth? Paul Saladino : 1229

Does Calorie Restriction Even Work? What About the Carnivore Diet AND Fruit?

Today we are excited to have Paul Saladino join us for a masterclass on food and diets. Dr. Saladino dives into the evolution of keto and carnivore diets, cutting through trends to focus on lasting health impacts. Dr. Saladino, widely recognized as CarnivoreMD, shares how his own diet shifted to include fruit and honey alongside animal-based nutrition, and why metabolic flexibility—not rigid rules—leads to better outcomes. Together, he and Dave challenge assumptions about long-term ketosis, examine its potential downsides, and explore how to optimize diets for energy, gut health, and longevity.

They also tackle controversial topics like the risks of seed oils, the overhyped reputation of “health foods” like quinoa, and the critical roles insulin and nutrient density play in overall wellness. With insights on balancing mTOR, managing omega fats, and incorporating organ meats, this episode offers a nuanced perspective for anyone interested in biohacking, nutrition science, or simply eating smarter.

What you’ll learn:

• Why metabolic flexibility matters more than strict diet rules

• The science behind long-term ketosis and insulin’s broader role in health

• How common “health foods” could be doing more harm than good

• The importance of nutrient-dense animal-based foods for gut and immune health

• How to achieve optimal balance between fat types, mTOR, and longevity markers

Resources:

2025 Biohacking Conferencehttps://biohackingconference.com/2025

Shop Paul Saladino’s Productshttps://heartandsoil.co

Follow Paul Saladino on Instagramhttps://www.instagram.com/paulsaladinomd/

Paul Saladino’s Book: The Carnivore Codehttps://www.amazon.com/Carnivore-Code-Unlocking-Returning-Ancestral/dp/035846997X

Lineage Provisions – 100% Grass-Fed Beef Tallowhttps://lineageprovisions.com/products/100-grass-fed-beef-tallow

Danger Coffeehttps://dangercoffee.com

Danger Coffee Instagramhttps://www.instagram.com/dangercoffeeofficial/

Dave Asprey’s Websitehttps://daveasprey.com

Dave Asprey’s Book: Smarter Not Harderhttps://daveasprey.com/books

Dave Asprey’s Linktreehttps://linktr.ee/daveasprey

Upgrade Collective: Join The Human Upgrade Podcast Livehttps://www.ourupgradecollective.com

Own an Upgrade Labshttps://ownanupgradelabs.com

Upgrade Labshttps://upgradelabs.com

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancementhttps://40yearsofzen.com


Sponsors:

- Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.

- LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/dave.


Timestamps:

00:00 Intro

00:40 Paul Saladino’s Evolution in Diet

01:21 Challenges of a Strict Carnivore Diet

03:36 Reintroducing Carbohydrates

05:32 Debunking Common Diet Myths

13:49 The Problem with Calorie Restriction

18:30 The Importance of Food Quality

24:08 The Veganism Debate

34:15 The Benefits of Organ Meats

37:27 Foot Surgery and Bone Density

39:23 Mineral Deficiency and Plant-Based Diets

40:00 The Truth About Seed Oils

41:10 Historical Studies on Seed Oils

47:26 Mechanisms and Effects of Seed Oils

52:33 Nicotine and Neuroprotection

54:12 Oleic Acid and Longevity

01:01:44 The Benefits of Animal Fats

01:02:32 Odd Chain Fatty Acids and Health

01:11:07 Cheese and Dairy Considerations

01:13:11 The Impact of Cheese on Health

01:14:03 Protein Intake and Longevity

01:14:54 Understanding mTOR and Its Effects

01:17:35 Ideal Body Fat and Metabolic Health

01:24:38 The Role of Omega Fatty Acids

01:32:46 ApoB, Insulin Sensitivity, and Longevity

01:43:09 Final Thoughts and Product Recommendations


See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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#5: How To Quantify Fatigue Like Never Before

#5: How To Quantify Fatigue Like Never Before

Rick Green and John Kalns have created the first test that can objectively measure fatigue.  Using an at-home test for salivary peptides, you can now gauge exactly how much stress your body is under.  This test can be used by athletes, or businessmen and entrepreneurs who burn the candle at both ends.  This is the first test which allows you to know when you’re really pushing your self too far. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Sep 201139min

#4: Evolutionary Psychiatry With Emily Deans (Paleo Brain Hacking)

#4: Evolutionary Psychiatry With Emily Deans (Paleo Brain Hacking)

Emily Deans is a board certified adult psychiatrist who uses evolutionary clues to solve modern mental illnesses.  She runs a popular blog called Evolutionary Psychiatry, and another blog on psychology today.  Emily is considered one of the top experts on the connection between nutrition and mental performance.  She is well respected in the “paleosphere”, and was kind enough to share her knowledge on Upgraded Self Radio. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Sep 20111h

#3: Hacking Fatigue With Tim Noakes (Plus More 4 Hour Body Fun)

#3: Hacking Fatigue With Tim Noakes (Plus More 4 Hour Body Fun)

Dr. Tim Noakes is one of the world’s foremost exercise scientists and the author of numerous books including the Lore of Running.  From the University of Cape Town exercise research center, Dr. Noakes has worked with some of the greatest athletes of all time.  His research is redefining the way we think about fatigue in sports and regular life.  A lifelong runner (71 marathons and ultra-marathons), writer, and researcher (and more recently, a paleo eater), Tim Noakes has used his knowledge to hack the human mind for improved athletic performance.  Whether you’re an athlete or a cubicle dweller, you need to here this interview. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Sep 20111h

#2: The Dark Side of Fat Loss With Sean Croxton

#2: The Dark Side of Fat Loss With Sean Croxton

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