Are GLP-1 Drugs "the Greatest Medical Breakthrough of the 21st Century"?

Are GLP-1 Drugs "the Greatest Medical Breakthrough of the 21st Century"?

In the past few years, we've learned that GLP-1 drugs don’t just help with diabetes or increase people’s feelings of fullness to help them lose weight. They have broad effects on substance abuse and behavior. They even seem to help with otherwise incurable illnesses, like Alzheimer's and schizophrenia. This month, a team of scientists studying 2 million patients in the Veterans Affairs medical system found that GLP-1s were associated with “a reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimer’s disease and dementia), coagulation disorders (clotting), cardiometabolic disorders (like strokes and heart attacks), infectious illnesses and several respiratory conditions.” Today’s guest is a coauthor on the paper, Ziyad Al-Aly. He is a physician-scientist at Washington University in St. Louis. We talk about his new paper, the steps he took to make sure his findings were trustworthy, why GLP-1 drugs might work so well, what they’re teaching us about the brain and body, how they’re scrambling our sense of where volition begins and where free will ends, and what scientists should do next with the revelation that these drugs have effects that go far beyond obesity and diabetes. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Ziyad Al-Aly Producer: Devon Baroldi Links: Al-Aly et al. on the effectiveness and risks of GLP-1 drugs [link] Learn more about your ad choices. Visit podcastchoices.com/adchoices

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The Omicron Variant: So, How Bad Is It?

The Omicron Variant: So, How Bad Is It?

Dr. Peter Hotez talks to Derek about what we know about the new COVID-19 variant (a little), what we don't know (a lot), and when we'll know more. Host: Derek Thompson Guests: Dr. Peter Hotez Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

30 Nov 202134min

Buy or Sell Pandemic Trends: Peloton, Movie Theaters, Masks, and More!

Buy or Sell Pandemic Trends: Peloton, Movie Theaters, Masks, and More!

The Atlantic's Amanda Mull joins the podcast to debate Derek about which COVID-19–related cultural trends will thrive or fade in the 2020s. Host: Derek Thompson Guest: Amanda Mull Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

23 Nov 202148min

We Have to Talk About Inflation

We Have to Talk About Inflation

Our first Economic Roundtable discusses rising prices, the Great Resignation, labor shortages, the supply chain mess, Joe Biden’s puking approval numbers, and what the White House can do to turn things around.  Host: Derek Thompson Guests: Michael Batnick and Ben Carlson  Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

19 Nov 202147min

The Future Is Going to Be Weird As Hell

The Future Is Going to Be Weird As Hell

In our first episode, The New York Times’s Kevin Roose joins the show to walk Derek through the metaverse, crypto, NFTs, and the maybe-BS or maybe-brilliant future of technology. Host: Derek Thompson Guest: Kevin Roose Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

16 Nov 202147min

Introducing Plain English with Derek Thompson

Introducing Plain English with Derek Thompson

Longtime Atlantic writer Derek Thompson breaks down your weekly headlines in his new podcast, ‘Plain English.’ From tech to politics to culture, Derek and his expert guests cut through the noise surrounding the news and tackle the big questions that matter to you. ‘Plain English’ launches November 16, with new episodes dropping every Tuesday and Friday. Host: Derek Thompson Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

11 Nov 202138s

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