Nature Podcast5 Mars 2025

Earliest crafted bone tools date back 1.5 million years

00:46 Ancient humans made bone tools 1.5 million years ago

A 1.5-million-year-old cache of animal-bone tools reveals that ancient humans systematically crafted with this material much earlier than previously thought. Researchers uncovered 27 bone artefacts in Tanzania honed into sharp tools almost 40 cm long. This discovery pushes back the dedicated manufacture of bone tools by around a million years and could have helped these early humans develop new kinds of technology. “This raises a lot of interesting questions,” says study author Ignacio de la Torre.

Research Article: de la Torre et al.

09:11 Research Highlights

Cane toads’ remarkable homing abilities, and evidence that the block of rock that makes up southern Tibet originated in what is now Australia.

Research Highlight: Take me home, country toads

Research Highlight: Lhasa′s rocks reveal an Australian birthplace

11:45 A trove of antibacterial molecules hidden in human proteins

To help protect against infection, cells in the body will selectively cut proteins to produce molecules known as antimicrobial peptides, according to new research. A team has found that many potential peptides appear to be locked up within proteins — to get them out, cells shift the activity of a waste-disposal system called the proteasome, known for its role in protein degradation and recycling. In tests, one of these peptides showed efficacy at protecting mice from infection, indicating that these molecules could one day have therapeutic potential.

Research Article: Goldberg et al.

News and Views: Protein waste turned into antibiotics as a defence strategy of human cells

21:08 Briefing Chat

An update on two missions heading to the Moon to look for water, and why fears that a crucial ocean-current system will collapse in the face of climate change may be incorrect.

Nature: Meet the ice-hunting robots headed for the Moon right now

Nature: Iconic ocean-current system is safe from climate collapse ― for now

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Briefing Chat: How 1,000 pairs of buried underpants helped measure soil health

In this episode:00:21 Our picks of this year’s Ig Nobel prizesNature: Buried underpants and a new definition of kissing win 2026 Ig Nobel prizes07:47 Massive xenon experiment detects tantalizing hint ...

4 Sep 12min

Audio long read: Could mending damaged DNA prolong life?

Scientists are amassing evidence that unrepaired or poorly repaired DNA damage underlies many of the hallmarks of ageing. This has led to research into whether boosting DNA repair can keep people heal...

2 Sep 18min

Briefing Chat: How Dolly Parton left her mark on science

In this episode:00:18 Researchers celebrate Dolly Parton's contributions to scienceNature: Dolly Parton dies aged 80 — researchers celebrate her contributions to science08:40 Phase III trial of melano...

28 Aug 14min

Highest-ever ocean temperatures recorded as El Niño intensifies

Why extreme temperatures are expected to weaken ocean carbon sinks — plus, how mitochondrial injections could treat vision loss.00:46 The world’s oceans reach a record temperatureNature: Ocean tempera...

26 Aug 19min

Briefing Chat: New narcolepsy drug could unlock host of novel brain therapies

Nature staff discuss how an FDA-approved drug for narcolepsy could have promise beyond the condition, and the longest-lived human brain organoids yet.00:28 The promise of a new narcolepsy drugNature: ...

21 Aug 12min

A black hole's spin could finally be measured by a high-speed star

Star orbiting close to Sagittarius A* could reveal its spin — plus, how exoskeletons might change the way humans move.00:46 The star that could reveal a black hole’s spinResearch article: Dayem et al....

19 Aug 29min

Briefing Chat: Anthropic rolls out new AI watermark — will it make a difference?

In this episode:00:29 What does Anthropic’s new watermark mean for research?Nature: Can Anthropic’s invisible watermarks curb ‘AI slop’? Researchers remain sceptical10:57 Ticklishness is a distinct, s...

14 Aug 16min

The probiotic bacteria engineered to treat diabetes

Genetically modified bacteria lower high blood-sugar in animal trials — plus, how to safely watch a solar eclipse.00:45 A living diabetes treatmentResearch article: Guan et al.08:03 Research Highlight...

12 Aug 19min