Can a Vaccine Cure the World’s Deadliest Cancer?

This week was a straight flush for Democrats. Zohran Mamdani completed his heroic arc to become mayor of the world’s most important city. Democrats ran up huge margins in the big governor races in Virginia and New Jersey, where Abigail Spanberger and Mikie Sherrill, respectively, won by double digits. What unified the three victories was the Democratic candidate’s ability to turn the affordability curse against the sitting president, transforming Republicans’ 2024 advantage into a 2025 albatross. Affordability is the Democrats’ new watchword. And it’s a good one. It speaks to Americans' direct concerns. It’s a big-tent subject, allowing a democratic socialist to offer one message in South Brooklyn and a moderate Democrat to offer another message in southern Virginia. Today’s guest is Matthew Yglesias, a writer whose site, Slow Boring, is a must-read for me and many others who follow politics and policy. We talk about the affordability theory of everything and its weaknesses, the Democrats’ big night, the lessons of Mamdani, persuasion, moderation, and much more. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Matthew Yglesias Producers: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

7 Nov 1h

Ken Burns—the award-winning filmmaker whose documentary films and television series on American history include 'The Civil War' (1990), 'Baseball' (1994), 'Jazz' (2001), and 'Country Music' (2019)—joins the show to talk about the American Revolution and the art of storytelling. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Ken Burns Producers: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

4 Nov 59min

Last week, an FBI investigation into gambling led to the arrest of several prominent basketball stars, raising questions about the state of legalized sports betting, which has enriched professional sports and sports media. The problems with sports gambling extend far beyond the integrity of the game. A 2024 working paper from economists at UCLA, Harvard, and USC found that states that legalized sports gambling after the 2018 ruling by the U.S. Supreme Court saw “a substantial increase in average bankruptcy rates, debt sent to collections, use of debt consolidation loans, and auto loan delinquencies. We also find that financial institutions respond to the reduced creditworthiness of consumers by restricting access to credit.” A separate analysis found that nearly one in five men aged 18-24 is on the spectrum of having a gambling problem. There’s no question that sports betting has taken over sports. It’s all over ESPN, all over my favorite sports podcasts. This podcast is a part of The Ringer Podcast Network, which has close relationships with the sports book FanDuel and has several shows devoted to gambling. I listen to them. Quite a lot, actually. It would be easier for me as the host of this episode if my position on gambling had the clarity of pure outrage. If I thought that gambling was a pure vice, a mere nuisance, and a total drag, I would say: Let’s just be done with it. On the opposite end, if I thought that legalized sports gambling posed no risk to bettors, didn’t threaten the integrity of professional sports, and represented an obvious improvement to the previous regime of black-market betting, I’d say: Ignore these moralizing bozos and place your 15-part parlay. The trouble is that I don’t have the advantage of clear outrage on this issue. I think that sports gambling is fun. And I think that it threatens the integrity of professional sports. And I think that it ruins some people’s lives. Today’s guest is Jonathan Cohen, the author of 'Losing Big: America’s Reckless Bet on Sports Gambling.' Like me, Jon is worried about the effect that legal sports gambling is having. Also like me, he sometimes bets on sports. Also like me, he listens to Ringer podcasts. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Jonathan Cohen Producers: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

31 Okt 54min

Bestselling author Michael Lewis joins the show to talk about how bubbles happen, the legacy of 'The Big Short' and the global financial crisis, 'Moneyball' and how the data analytics revolution conquered sports and entertainment, the difference between being a good investor and being a good investigative journalist, and the craft of writing. Listen to the new audiobook of Michael's hit 'The Big Short' ⁠HERE⁠! If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Michael Lewis Producers: Devon Baroldi and Kaya McMullen Learn more about your ad choices. Visit podcastchoices.com/adchoices

28 Okt 1h 12min

Today’s guest is Ethan Mollick. Ethan is a professor of management at Wharton, where he specializes in entrepreneurship and innovation. He is the author of the book 'Co-Intelligence: Living and Working With AI,' and his Substack, One Useful Thing, is the single most useful guide I have ever found to make sense of these tools and use them productively. But he’s also a deep thinker of the Alfred Chandler school of big ideas who wants to not only help individuals use the technology more efficiently but also understand what happens as tens of millions and billions of people use the technology to make themselves more productive or even, at times, obsolete. Host: Derek ThompsonGuest: Ethan MollickProducers: Devon Baroldi and Devon Renaldo Learn more about your ad choices. Visit podcastchoices.com/adchoices

24 Okt 54min

By some measures, the Democratic Party has never been so unpopular as a political brand. While this fact obviously reflects some difficult realities for the party, it also creates an opportunity for Democrats to redefine what the party stands for. Derek talks to Massachusetts Congressman Jake Auchincloss about his idea for a digital dopamine tax, the art of politics in an attention economy, why moderate Democrats don't have big bold ideas, Derek's two-party theory for political success in America, and more. Host: Derek ThompsonGuest: Jake AuchinclossProducers: Devon Baroldi and Devon Renaldo Learn more about your ad choices. Visit podcastchoices.com/adchoices

21 Okt 59min

Two weeks ago, in one of our most popular podcasts of the year, the investor and author Paul Kedrosky explained why he thinks AI is a bubble. In the last few days, practically everybody seems to agree.I hate this. I don’t like feeling like my position is the same position as everybody else’s. Conventional wisdoms are often more conventional than wise, and I’ve started to wonder: Is there a bubble of people calling AI a bubble?Today’s guest says yes. Azeem Azhar is an investor and the author of the blog Exponential View. Like Paul, Azeem is a fantastic explainer and storyteller, and I’m satisfied that Plain English has now presented the strongest possible arguments for and against AI being a bubble. If you want to know where I land, you’ll just have to listen to the end of the show. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek ThompsonGuest: Azeem AzharProducers: Devon Baroldi and Kaya McMullen Learn more about your ad choices. Visit podcastchoices.com/adchoices

17 Okt 52min

In the second episode of our two-part miniseries on the future of entertainment, Derek goes from Hollywood to NYC to understand why Broadway musicals are in trouble. "With the cost of staging song-and-dance spectacles skyrocketing and audiences drawn to older hits, none of the musicals that opened last season have made a profit," The New York Times recently reported. John Johnson, a major theater producer behind hits like 'Stereophonic' (the most Tony-nominated play in Broadway history) and George Clooney's 'Good Night, and Good Luck,' joins the show to discuss the future of live theater, the death of the middle in American entertainment, and how to cultivate good "taste" in popular art. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek ThompsonGuest: John JohnsonProducers: Devon Baroldi and Kaya McMullen Learn more about your ad choices. Visit podcastchoices.com/adchoices

14 Okt 47min