Can a Vaccine Cure the World’s Deadliest Cancer?

Can a Vaccine Cure the World’s Deadliest Cancer?

Cancer is not a singular disease but a category of hundreds, even thousands, of rare diseases with different molecular signatures and genetic roots. Cancer scientists are looking for a thousand perfect keys to pick a thousand stubborn locks. Today's episode is about the hardest lock of them all: pancreatic cancer. Cancer’s power lives in its camouflage. The immune system is often compared to a military search and destroy operation, with our T cells serving as the expert snipers, hunting down antigens and taking them out. But cancer kills so many of us because it looks so much like us. Pancreatic cancer is so deadly in part because it's expert at hiding itself from the immune system. Now, here’s the good news. This might be the brightest moment for progress in pancreatic cancer research in decades—and possibly ever. In the past few years, scientists have developed new drugs that target the key gene mutation responsible for out of control cell growth. Recently, a team of scientists at Oregon Health and Science University claimed to have developed a blood test that is 85 percent accurate at early-stage detection of pancreatic cancer, which is absolutely critical given how advanced the cancer is by the time it’s typically caught. And last month, a research center at Memorial Sloan Kettering published a truly extraordinary paper. Using mRNA technology similar to the COVID vaccines, a team of scientists designed a personalized therapy to buff up the immune systems of people with pancreatic cancer. Patients who responded to the treatment saw results that boggle the mind: 75 percent were cancer-free three years after their initial treatment. Not just alive, which would be its own minor miracle. But cancer-free. The mRNA vaccine, administered within a regimen of standard drugs, stood up to the deadliest cancer of them all and won. Today’s guest is the head of that research center, the surgical oncologist Vinod Balachandran. The concept of a personalized cancer vaccine is still unproven at scale. But if it works, the potential is enormous. But again: Cancer does not exist, as a singular disease. Cancer is a category of rare diseases, many of which are exquisitely specific to the molecular mosaic of the patient. Cancers are personal. Perhaps in a few years, our cures for cancers will be equally personalized. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Vinod Balachandran Producer: Devon Baroldi Links: Cancer Vaccine paper: https://www.nature.com/articles/s41586-024-08508-4 P.S. Derek wrote a new book! It’s called 'Abundance,' and it’s about an optimistic vision for politics, science, and technology that gets America building again. Buy it here: https://www.simonandschuster.com/books/Abundance/Ezra-Klein/9781668023488 Plus: If you live in Seattle, Atlanta, or the Raleigh-Durham-Chapel Hill area, Derek is coming your way in March! See him live at book events in your city. Tickets here: The Abundance Book Tour Learn more about your ad choices. Visit podcastchoices.com/adchoices

Avsnitt(341)

How Putin's War Will End

How Putin's War Will End

Quagmire. Regime change. Conquest. Empire. World War III. Derek considers five ways that the war in Ukraine could end with Paul Poast, a professor of foreign policy and war at the University of Chicago. This is Part 2 of our two-part Ukraine coverage today. For more on why Putin attacked and how war could change the world, check out the previous episode in this feed. Host: Derek Thompson Guest: Paul Poast Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

25 Feb 202244min

What Vladimir Putin Wants—and How Russia’s War in Ukraine Could Reshape the World

What Vladimir Putin Wants—and How Russia’s War in Ukraine Could Reshape the World

Derek explains why three years—1989, 2008, and 2014—are the key to understanding why Putin is willing to take a massive risk in invading Ukraine. Then, Derek asks five expert guests to walk him through the most important second-order implications of a long major conflict. What are the most important ricochet effects that nobody is talking about? How could the war transform Europe? How could it destabilize Africa and the Middle East? How will it change U.S. politics, or kick off a 21st Century Cold War? Host: Derek Thompson Guests: Charles Kupchan, Liana Fix, Matthew Klein, Alex Smith, Bonny Lin Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

25 Feb 202231min

Four Brilliant Frames for Finding the Next Big Thing, With Venture Capitalist Josh Wolfe. Plus, What's Eating Tech Stocks in 2022?

Four Brilliant Frames for Finding the Next Big Thing, With Venture Capitalist Josh Wolfe. Plus, What's Eating Tech Stocks in 2022?

All-star VC Josh Wolfe of Lux Capital joins the show to talk about picking winners and losers, tech's rough start to the year, and his four favorite mottos for detecting BS and seeing reality clearly. Finally, Derek and Josh play a game of "Overrated or Underrated?" for the metaverse, NFTs, and space travel. Host: Derek Thompson Guest: Josh Wolfe Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

22 Feb 202247min

The Great Debate: What's the Single Most Amazing Sports Statistic in U.S. History?

The Great Debate: What's the Single Most Amazing Sports Statistic in U.S. History?

Wilt Chamberlain’s 100-point game. Joe DiMaggio’s 56-game hit streak. Jerry Rice's gazillion receiving records. Which of these athletic achievements is the most impressive in American sports history? And are any of them the most impressive ever? The Ringer's Ryen Russillo joins the pod to debate the most impressive achievements in football, basketball, baseball, and individual sports. Then, after making selections that will almost certainly infuriate at least half of all listeners, the guys compare the GOATs across sports to name the single most impressive accomplishment ever. (Hint: Ironically, the award goes to a non-American.) Host: Derek Thompson Guest: Ryen Russillo Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

18 Feb 202255min

What American Media Is Getting Wrong About Canada’s Big Protests

What American Media Is Getting Wrong About Canada’s Big Protests

What if I told you that the anti-vaccination trucker protests in Canada weren’t principally about vaccines or truckers (or even Canada)? The Atlantic’s David Frum joins to set us straight about what’s going on in Ottawa and the meme-ification of protest politics. Host: Derek Thompson Guest: David Frum Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

15 Feb 202226min

The Meaning of Life and the Power of Regret

The Meaning of Life and the Power of Regret

Derek goes deep with bestselling author Dan Pink on his new book, 'The Power of Regret.' This episode was recorded in front of a live audience at the Sixth & I historic synagogue in Washington, D.C. Host: Derek Thompson Guest: Dan Pink  Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

11 Feb 202246min

Media Gossip Hour: Spotify's Joe Rogan Problem, Facebook's TikTok Crisis, and Crypto's Anonymity Conundrum

Media Gossip Hour: Spotify's Joe Rogan Problem, Facebook's TikTok Crisis, and Crypto's Anonymity Conundrum

Kevin Roose of The New York Times returns to our pod, which is owned by Spotify, to talk about Joe Rogan’s podcast, which is exclusively licensed by Spotify. (That's transparency, folks.) Then we talk about Mark Zuckerberg’s big stock market wipeout, and Kevin explains the latest NFT controversy to Derek like he’s 5 years old. Host: Derek Thompson Guest: Kevin Roose Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

8 Feb 202252min

This Guy Predicted the 2021 Economy. I Asked Him What's Next.

This Guy Predicted the 2021 Economy. I Asked Him What's Next.

Jason Furman is a Harvard professor who served as a top economist for the Obama administration. More than just about anybody Derek spoke to last year, he nailed the rise in inflation. What did he see that others didn't? What's happening to inflation, the Great Resignation, labor shortages, and the Federal Reserve right now? And what will happen in 2022? Host: Derek Thompson Guest: Jason Furman Producer: Devon Manze Learn more about your ad choices. Visit podcastchoices.com/adchoices

4 Feb 202248min

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