Ep. 142: Papers of the Month: Mismatch Repair & DNA Expansion in Huntington’s Disease
eanCast: Weekly Neurology6 Apr 2025

Ep. 142: Papers of the Month: Mismatch Repair & DNA Expansion in Huntington’s Disease

Moderator: Jean-Marc Burgunder (Guemligen, Switzerland)Guest: Sandrine Humbert (Paris, France)In this week's episode, Burgunder and Humbert discuss the intriguing phenomenon of somatic expansion—the further increase of CAG repeat numbers in the gene involved in Huntington’s disease, particularly in the striatum. They explore the molecular mechanisms behind this process, as addressed in two recent research papers.Please find here the papers discussed in this episode: Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s diseaseand Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice.eanCampus access for Associate Members: If you are a member of a National Neurological Society in Europe, you are most likely aleady an Associate Member of the EAN and have an account for the eanCampus. If you have provided your email address to your National Neurological Society, it should already be in our database. Here is how you can access the eanCampus as an Associate Member:1. Enter the eanCampus2. Click on the Log In Button3. Log in with your MyEAN credentials and make use of the ‘forgot password’-functionality if necessaryIf you have trouble logging in, please get in contact with our Membership department (membership@ean.org) to cross-check if you are listed as an Associate Member to get access to eanCampus.

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Ep. 14: Multiple Sclerosis Article of the Month

Ep. 14: Multiple Sclerosis Article of the Month

Moderator: Prof. Christian Enzinger (Graz, Austria) Guest: Dr. Antonia Lefter (Bucharest, Romania) Prof. Christian Enzinger and Dr. Antonia Lefter discuss a recent article on Multiple Sclerosis progre...

25 Sep 202216min

Ep. 13: Real-world data in Multiple Sclerosis

Ep. 13: Real-world data in Multiple Sclerosis

Moderator: Prof. Christian Enzinger (Graz, Austria) Guest: Dr. Melinda Magyari (Copenhagen, Denmark) Prof. Christian Enzinger speaks with Dr. Melinda Magyari regarding real-world Multiple Sclerosis da...

18 Sep 202222min

Ep. 12: MRI in Multiple Sclerosis

Ep. 12: MRI in Multiple Sclerosis

Moderator: Prof. Christian Enzinger (Graz, Austria) Guest: Dr. Paolo Preziosa (Milan, Italy) Prof. Christian Enzinger speaks with specialist Dr. Paolo Preziosa to gain insight on the use of MRI in the...

11 Sep 202225min

Ep. 11: A primer to Multiple Sclerosis

Ep. 11: A primer to Multiple Sclerosis

Moderator: Prof. Christian Enzinger (Graz, Austria) Guest: Prof. Andrew Chan (Bern, Switzerland) Prof. Christian Enzinger, co-chair of the EAN Scientific Panel on Multiple Sclerosis, moderates the fir...

4 Sep 202221min

Ep. 10: Brain Health

Ep. 10: Brain Health

Moderator: Prof. Barbara Tettenborn (St. Gallen, Switzerland) Guest: Prof. Claudio Bassetti (Bern, Switzerland) For this special episode Prof. Barbara Tettenborn sits down Prof. Claudio Bassetti, form...

28 Aug 202214min

Ep. 9: Stroke in Women

Ep. 9: Stroke in Women

Moderator: Prof. Barbara Tettenborn (St. Gallen, Switzerland) Guest: Dr. Cheryl Carcel (Sydney, Australia) For the final episode focusing on Stroke Prof. Barbara Tettenborn meets with Dr. Cheryl Carce...

21 Aug 202214min

Ep. 8: Intracerebral hemorrhage

Ep. 8: Intracerebral hemorrhage

Moderator: Prof. Barbara Tettenborn (St. Gallen, Switzerland) Guest: Prof. Dr. Thorsten Steiner (Frankfurt, Germany) Prof. Barbara Tettenborn speaks with Prof. Dr. Thorsten Steiner about the etiology,...

14 Aug 202221min

Ep. 7: Pre-Hospital Care

Ep. 7: Pre-Hospital Care

Moderator: Prof. Barbara Tettenborn (St. Gallen, Switzerland) Guest: Prof. Simon Jung (Bern, Switzerland) Prof. Barbara Tettenborn speaks with Stroke specialist Prof. Simon Jung to gain insight on acu...

7 Aug 202218min

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