#585: Professor Donald Hoffman — The Case Against Reality, Beyond Spacetime, Rethinking Death, Panpsychism, QBism, and More

#585: Professor Donald Hoffman — The Case Against Reality, Beyond Spacetime, Rethinking Death, Panpsychism, QBism, and More

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Donald Hoffman ( @donalddhoffman) received a PhD in computational psychology from MIT and is a Professor Emeritus of Cognitive Sciences at the University of California, Irvine. He is an author of over 120 scientific papers and three books, including The Case Against Reality: Why Evolution Hid the Truth from Our Eyes. He is the recipient of the Distinguished Scientific Award of the American Psychological Association and the Troland Research Award of the US National Academy of Sciences.

His writing has appeared in Scientific American, New Scientist, LA Review of Books, and Edge, and his work has been featured in Wired, Quanta, The Atlantic, Ars Technica, National Public Radio, Discover Magazine, and Through the Wormhole with Morgan Freeman. His TED Talk, titled “Do We See Reality as It Is?,” has almost 4M views.

Please enjoy!

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What was the Helmholtz Club, and how did it spark a scientific exploration into the meaning of consciousness? [06:19]

What is consciousness? [11:24]

How should we understand our perceptions and their relationship to reality? David walks us through the desktop interface metaphor as presented in his 2015 TED Talk, and explains why it’s unlikely (with a probability of zero) that human beings evolved to behold the naked entirety of reality. [14:08]

Why does Donald, as a cognitive neuroscientist, find this era of physicists exploring consciousness and the nature of an underlying reality we haven’t evolved to see so exciting? Also: is spacetime doomed? [20:31]

Will science ever arrive at a theory of everything? [33:00]

What is the holographic model of the universe? [37:13]

What might things look like in the next decade or two as we begin to fundamentally revise how we think of reality, matter, and the interplay of consciousness? [43:09]

How does Donald scientifically explore the concept of conscious agents? [49:48]

Is consciousness localized, or does the brain “receive” it from elsewhere? [53:20]

How does Donald think about death? [58:55]

What are Markovian dynamics? [1:05:27]

Supplementary information that might help someone who’s struggling to understand parts of this conversation. [1:07:14]

What is panpsychism, and who are some of the most influential panpsychists? [1:08:38]

Which aspects of the way we interface with reality give us effective portals into life or consciousness? [1:12:11]

Probing the deeper reality suggested by the amplituhedron, associahedron, and cosmological polytope. [1:14:51]

At which hallowed institutions are these explorations of consciousness and the nature of a deeper reality being researched, and who is leading the charge? [1:20:18]

Donald’s thoughts on the use of hallucinogenic drugs to tap into deeper reality and interact with conscious agents. [1:21:22]

Exploring a theory involving portals and morphogenesis. [1:23:18]

It’s worth considering ethnobotanical and ethnographical studies that may give us more focused insight into consciousness through a non-Western lens and even have us questioning if plants can be considered a sentient part of this consciousness. [1:27:20]

On Chris Fuchs and the outer fringes of Quantum Bayesian — aka QBism. [1:35:38]

The experiments Donald would conduct in his research with unlimited funding over the next 10 years, and with whom he would choose to work. [1:40:31]

What is Donald reading these days? [1:42:43]

Donald names some of his long-time collaborators who pair mathematics with spiritual practice, and describes how he reconciles the two in his own work. [1:47:34]

How much pushback has Donald suffered for bringing spirituality into his scientific endeavors? Has any of it been constructive? [2:00:51]

How does fitness payoff function work in evolutionary theory, and how does this support the probability of zero that humans evolved to see reality in full? [2:03:27]

Parting thoughts. [2:05:46]

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#839: Dr. Fei-Fei Li, The Godmother of AI — Asking Audacious Questions, Civilizational Technology, and Finding Your North Star

#839: Dr. Fei-Fei Li, The Godmother of AI — Asking Audacious Questions, Civilizational Technology, and Finding Your North Star

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#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

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#837: How to Simplify Your Life in 2026 — New Tips from Derek Sivers, Seth Godin, and Martha Beck

#837: How to Simplify Your Life in 2026 — New Tips from Derek Sivers, Seth Godin, and Martha Beck

As we head into the new year, many of us feel like we’re drowning in invisible complexity. So I wanted to hit pause and ask a simple question: What are 1-3 decisions that could dramatically simplify m...

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#836: The 4-Hour Workweek Principles — 13 Mistakes to Avoid, The Art of Mini-Retirements, and Navigating the Dizziness of Freedom

#836: The 4-Hour Workweek Principles — 13 Mistakes to Avoid, The Art of Mini-Retirements, and Navigating the Dizziness of Freedom

This time around, we have a bit of a different format, featuring the book that started it all for me, The 4-Hour Workweek. Readers and listeners often ask me what I would change or update, but an equa...

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#835: Ben Patrick (KneesOverToesGuy) — 20-Minute Workouts That Produce Wild Results, From Chronic Knee Pain to Dunking Basketballs, Lessons from Charles Poliquin, Bulletproofing the Lower Body, and More

#835: Ben Patrick (KneesOverToesGuy) — 20-Minute Workouts That Produce Wild Results, From Chronic Knee Pain to Dunking Basketballs, Lessons from Charles Poliquin, Bulletproofing the Lower Body, and More

Ben Patrick, better known as “Kneesovertoesguy” (@kneesovertoesguy), is the founder of Athletic Truth Group (ATG), an online and brick-and-mortar training system rooted in rehabilitative strength and ...

12 Nov 20251h 37min

#834: David Baszucki, Co-Founder of Roblox — The Path to 150M+ Daily Users, Critical Business Decisions, Ketogenic Therapy for Brain Health, Daily Routines, The Roblox Economy, and More

#834: David Baszucki, Co-Founder of Roblox — The Path to 150M+ Daily Users, Critical Business Decisions, Ketogenic Therapy for Brain Health, Daily Routines, The Roblox Economy, and More

David Baszucki is the founder and CEO of Roblox. TIME named Roblox one of the “100 Most Influential Companies,” and it has been recognized by Fast Company for innovation on their “Most Innovative Comp...

5 Nov 20251h 55min

#833: Jack Canfield — Selling 600+ Million Books, Success Principles, and How He Made The 4-Hour Workweek Happen

#833: Jack Canfield — Selling 600+ Million Books, Success Principles, and How He Made The 4-Hour Workweek Happen

Jack Canfield is the coauthor of more than two hundred books, including, The Success Principles™: How to Get from Where You Are to Where You Want to Be and the Chicken Soup for the Soul® series, which...

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#832: The Return of The Lion Tracker — Boyd Varty on The Wild Man Within, Nature’s Hidden Wisdom, and How to Feel Fully Alive

#832: The Return of The Lion Tracker — Boyd Varty on The Wild Man Within, Nature’s Hidden Wisdom, and How to Feel Fully Alive

Boyd Varty is the founder of Track Your Life, which offers a limited number of premium retreats in South Africa’s bushveld, and author of one of my favorite books, The Lion Tracker’s Guide to Life. As...

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