Why Big Pharma Hates Nitric Oxide (And How to Use It Anyway) : 1302

Why Big Pharma Hates Nitric Oxide (And How to Use It Anyway) : 1302

If you care about longevity, brain optimization, sexual performance, or metabolism, this molecule changes everything. Host Dave Asprey sits down with nitric oxide pioneer Dr. Nathan Bryan to reveal why this overlooked molecule controls your blood flow, mitochondrial energy, neuroplasticity, insulin response, and even your libido. You’ll learn how nitric oxide acts as a master switch for human performance and why the medical system has ignored it for decades.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Dr. Nathan Bryan is a world-renowned expert in nitric oxide biochemistry with over 20 years of clinical research, multiple patents, and collaborations with Nobel Prize-winning scientists. His groundbreaking work forms the foundation for modern functional medicine protocols targeting blood flow, metabolism, cognitive enhancement, and mitochondrial upgrades.


You’ll learn:

• How nitric oxide drives mitochondria, metabolism, and human performance

• Why most nitric oxide supplements fail and how to spot real ones

• The critical role nitric oxide plays in brain optimization, libido, and insulin signaling

• How poor oral health, statins, and PPIs can kill nitric oxide production

• What nitric oxide has to do with sleep optimization, aging, and disease prevention

• How to stack nitric oxide with fasting, ketosis, nootropics, red light, and supplements

• Why “Smarter Not Harder” starts with nitric oxide fueled upgrades


This episode is essential listening for anyone into biohacking, cold therapy, functional medicine, or RFK-style medical freedom. You’ll walk away with practical tools to boost nitric oxide naturally, prevent dysfunction, and optimize your biology whether you’re on a carnivore diet or just looking for an edge.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.


Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.


Get Nitric Oxide products for 10% off with code ‘Dave’: https://bit.ly/Nitric-Oxide-Product


SPONSORS:


Resources:

• Nathan’s Website: https://www.n1o1.com

• Nathan’s YouTube: https://www.youtube.com/channel/UCtftGy8e0r9DO8ActcyGi4w

• Dave Asprey’s Website: https://daveasprey.com

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

• 00:00 Trailer

• 01:03 Intro

• 01:15 Why Medicine Ignores Nitric Oxide

• 01:59 What Nitric Oxide Does in the Body

• 04:46 How the Body Makes Nitric Oxide

• 07:12 Diet’s Impact on NO Levels

• 13:28 Why Most NO Supplements Fail

• 19:32 Personalized Biohacking with NO

• 22:33 How Medicine Misses the Mark

• 30:40 Oral Health and Nitric Oxide

• 31:30 Mouthwash Kills Your Microbiome

• 32:28 The Problem with Fluoride

• 33:25 Better Toothpaste for NO

• 33:49 NO’s Role in Energy and Healing

• 34:17 Blood Pressure and NO

• 35:29 NO and Sexual Performance

• 37:09 NO and COVID Recovery

• 40:50 Brain Fog and NO Deficiency

• 49:01 Carnivore, Sugar, and NO

• 50:11 Why You Still Need NO Supplements

• 54:19 Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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The New Fasting Protocol to Increase Lifespan by 96% | Chris Rhodes : 1254

The New Fasting Protocol to Increase Lifespan by 96% | Chris Rhodes : 1254

Can You Mimic Fasting—Without Actually Fasting? Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health. Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food. Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation. For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating. What You’ll Learn: • The optimal fasting window for maximizing lifespan (Hint: It’s not 16 hours) • The four fasting metabolites that extend life by 96% • How Mimio mimics fasting benefits—without giving up food • The real reason over-fasting destroys your metabolism and hormones • Why traditional longevity drugs (Metformin, Rapamycin) fall short • Can you build muscle and burn fat at the same time? The science of mTOR & AMPK • Why Big Pharma doesn’t want you to know about this breakthrough *** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE *** Sponsors:Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Mimio Instagram: https://www.instagram.com/mimiohealth/ • Mimio Website: https://mimiohealth.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:58 – Fasting & Longevity • 01:88 – Optimal Fasting Length • 03:39 – Alternate Day Fasting: Pros & Cons • 05:50 – Key Fasting Compounds • 07:34 – Spermidine & Longevity Molecules • 11:41 – FDA Roadblocks on Natural Compounds • 15:37 – AI, Big Data & Longevity Research • 31:19 – Mimio’s Impact on Testosterone & Aging • 35:16 – Longevity & Death Philosophy • 36:48 – Biohacking Origins • 37:03 – Metabolism & Cognitive Function • 38:35 – Unexpected Effects of Fasting • 40:43 – Fasting & Circadian Rhythms • 43:09 – Mimio Science & Benefits • 45:14 – Mimio in a Daily Routine • 55:05 – Men vs. Women: Fasting Differences • 01:02:23 – Future of Nutrition & Biohacking • 01:07:21 – Conclusion & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Feb 1h 6min

The Secret Molecule for Endless Energy | Dr. Andrew Salzman : 1253

The Secret Molecule for Endless Energy | Dr. Andrew Salzman : 1253

Could a single molecule be the difference between vibrant longevity and early decline? Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal the real key to living longer, fighting disease, and maximizing your energy: NAD. This master molecule fuels your mitochondria, DNA repair, and cellular resilience, but here’s the catch—it plummets as you age. That means more fatigue, brain fog, inflammation, and higher risks of disease. But what if you could stop the decline and even reverse it? Dr. Salzman breaks down the game-changing science behind NAD, CD38, and cellular repair—and the fastest, most effective ways to optimize your levels for peak performance, health, and longevity. Get ready to rethink everything you thought you knew about aging, pharmaceuticals vs. supplements, and the radical new approach to living better, longer. What You’ll Learn: • The #1 reason your NAD is disappearing—and how to fix it • Why NAD is the missing link in energy, DNA repair, and disease prevention • The hidden enzyme (CD38) that’s sabotaging your longevity • How to supercharge mitochondria, optimize blood flow, and fight aging at the source • Why the supplement industry has it wrong—and the best way to boost NAD naturally • The shocking truth about the FDA, pharmaceuticals, and the future of anti-aging medicine Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Wonderfeel Instagram – https://www.instagram.com/getwonderfeel/ • Wonderfeel Supplement : https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: 00:00 Trailer 01:07 Introduction and Episode Overview 02:29 Meet Dr. Andrew Salzman 02:36 From Physician to Researcher 03:39 Pharmaceuticals vs. Nutritionals 04:17 The Role of NAD in Longevity 06:32 Challenges in Longevity Research 12:58 Understanding NAD and PARP 14:34 NAD’s Impact on Health 23:19 Gut Health and Longevity 27:43 Innovations in NAD Supplementation 41:27 Customer Feedback and Product Effectiveness 42:41 Surprising Benefits of NAD for Sexual Health 44:47 NAD and Vascular Health 48:46 NAD’s Role in Aging and Longevity 54:03 NAD and Lifestyle Choices 01:03:02 NAD and Cognitive Function 01:06:18 NAD and Exercise 01:13:42 NAD and Sleep 01:21:54 Final Thoughts on NAD and Longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Feb 1h 24min

Fix Your Blood Sugar: The FASTEST Way to Burn Fat, Optimize Hormones & Reverse Disease | Benjamin Bikman  : 1252

Fix Your Blood Sugar: The FASTEST Way to Burn Fat, Optimize Hormones & Reverse Disease | Benjamin Bikman : 1252

Welcome to the metabolism masterclass!Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast. From debunking diet myths to uncovering why some people can eat 400 grams of carbs and never gain fat (hint: it’s not what you think), this episode unpacks the real science of fat storage, energy, and optimal health. Get ready for mind-blowing insights, metabolic hacks, and a new way to think about food, fasting, and longevity. What You’ll Learn: • The #1 driver of insulin resistance—and why most doctors miss it • Why eating more fat (yes, really) could be the key to reversing metabolic dysfunction • How fasting, cold therapy, and red light impact your metabolism • The truth about carbs, seed oils, and why some people can’t gain fat • How to tell if insulin resistance is wrecking your energy & health Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Benjamin’s new book How Not To Get Sick : https://a.co/d/aADlMWv • Benjamin’s YouTube Page – https://www.youtube.com/@benbikman • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: -Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Timestamps: 00:00 Trailer 00:52 Introduction to Dr. Benjamin Bikman 02:20 The Battle Against Conventional Dietetics 04:12 Understanding Insulin Resistance 06:29 The Two Paths to Insulin Resistance 10:19 Fasting and Metabolic Health 14:11 Insulin and Cognitive Enhancement 18:16 Identifying Insulin Resistance 30:12 The Role of Insulin in Fat Storage 42:04 Understanding Glucose and Insulin Dynamics 42:26 The Role of Exercise in Glucose Regulation 42:54 AMPK and Muscle Contraction 45:21 Calories In, Calories Out Debate 46:15 The Myth of Calorie Counting 50:13 Ketosis and Metabolic Rate 51:14 Intermittent Fasting and Muscle Preservation 55:21 Insulin Resistance and Ketogenic Diets 01:02:04 Circadian Rhythm and Insulin Sensitivity 01:08:08 Environmental Toxins and Insulin Resistance 01:13:03 The Impact of Seed Oils on Insulin Resistance 01:19:22 Final Thoughts and Resources See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Feb 1h 20min

Rick Rubin: How to Hack Your Mind for Creative Breakthroughs : 1251

Rick Rubin: How to Hack Your Mind for Creative Breakthroughs : 1251

Most people wait for inspiration. But what if you could train your brain to create on demand? Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius? In this must-listen episode, Rick sits down with Dave to explore the science and soul of creativity, revealing how meditation, mindfulness, biohacking, and unconventional thinking fuel artistic breakthroughs. From rewiring your brain with meditation to stacking biohacks for peak creative flow, Rick shares the techniques that have kept him at the top of the music industry for over 40 years. Dave and Rick go deep on the mental and physiological hacks that enhance creative performance, the surprising link between biohacking and artistry, and the rituals that keep Rick sharp, focused, and endlessly inspired. What You’ll Learn: • How Rick Rubin taps into creative flow—and how you can too • The surprising connection between meditation and peak artistic performance • Why biohacking isn’t just for longevity—it’s for creative mastery • Rick’s favorite tools for mental clarity, focus, and creative breakthroughs • The real secret behind working with the world’s biggest artists • How to cultivate an environment that fuels creativity Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Rick’s New Book The Creative Act: A way of Being: https://a.co/d/2bLbjeS • Rick’s Instagram: https://www.instagram.com/rickrubin/?hl=en • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off. BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. Timestamps: • 00:00 – Trailer • 00:51 – Intro to Rick Rubin • 02:51 – Rick’s Musical Journey • 03:06 – The Creative Process • 08:31 – Biohacking & Sensitivity • 13:46 – Meditation & Creativity • 19:37 – Rick’s Weight Loss Story • 29:21 – Eating Habits & Rhythm • 29:55 – Advanced Biohacking • 31:23 – Oxygen Therapy & Carbogen • 35:16 – Peptides & Longevity • 45:59 – Prayer, Gratitude & Performance • 51:03 – Reflections on Life & Mortality See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Feb 54min

Tony Robbins on the Ultimate Secrets to Wealth, Mindset, and Success  : 1250

Tony Robbins on the Ultimate Secrets to Wealth, Mindset, and Success : 1250

What’s keeping you stuck in a scarcity mindset instead of stepping into abundance? What truly sets successful people apart from those who struggle? Tony Robbins has spent decades answering these questions—coaching billionaires, world leaders, elite athletes, and everyday people to master their money, mindset, and mission. In this all-time classic podcast, he shares the hard-hitting truths about financial freedom, why fear is your biggest enemy, and how to break free from the psychological traps that keep you stuck. Tony and Dave dive deep into the wealth-building playbook that the world’s top investors use (including Warren Buffett, Ray Dalio, and Paul Tudor Jones), plus the biohacks and routines that fuel Tony’s legendary stamina. From the real secret to compounding wealth to stem cell breakthroughs that could change human longevity, this episode will shift the way you think about money, health, and success. Most people dream of financial freedom, but few actually achieve it. What’s holding you back—and how can you break through? What You’ll Learn: • The biggest mistake people make with money (and how to avoid it) • The mindset of the ultra-wealthy—how top investors think differently • Why fear is your greatest enemy in investing and personal success • The three essential money buckets—security, growth, and dreams • Tony’s top biohacks for insane energy and peak performance • The real secret to happiness and fulfillment (it’s not what you think) Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Tony’s Website: https://www.tonyrobbins.com/ • Tony’s Instagram: https://www.instagram.com/tonyrobbins/?hl=en • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: -Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Timestamps: • 00:00 Intro • 00:50 Meet Tony Robbins • 02:18 Financial Wisdom & Motivation • 05:43 Psychology of Wealth • 10:10 Investment Strategies • 15:24 Balancing Money & Experiences • 21:21 Power of Giving • 30:06 Paying for College • 31:00 Commitment & Success • 31:53 Energy & Biohacks • 35:12 Cryotherapy & Inflammation • 38:54 Stem Cells & Regeneration • 41:59 Financial Freedom • 46:35 Wnt Pathway Breakthroughs • 52:35 Health & Longevity • 56:34 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Feb 56min

Timbaland's Blueprint: How to Lose 130 Pounds, Beat Addiction, and Change Your Life TODAY!  : 1249

Timbaland's Blueprint: How to Lose 130 Pounds, Beat Addiction, and Change Your Life TODAY! : 1249

From chart-topping hits to life-threatening lows—how did Timbaland go from producing for Jay-Z, Beyoncé, and Justin Timberlake to battling addiction and obesity? And more importantly, how did he take his life back? In this raw and revealing conversation, music icon Timbaland shares the blueprint behind his incredible transformation—how he broke free from opioid addiction, lost 130 pounds, and rewired his mindset for long-term success. He and Dave dive into the power of discipline, the dangers of quick fixes, and the hard truths about personal transformation. Timbaland opens up about the mental shift that saved his life, how he kicked a high-dose opioid habit cold turkey, and why his new “drug” of choice is something anyone can access. Most people want change, but few actually achieve it. What separates those who succeed from those who stay stuck? And how can you apply Timbaland’s hard-earned lessons to your own life? What You’ll Learn: • The #1 mindset shift that made weight loss & addiction recovery possible • Why self-discipline beats willpower—and how to build it like a muscle • The real reason most diets fail—and what actually works • The truth about opioid addiction and recovery—why most people never escape • How your daily habits shape your future—and how to change them fast • The shocking link between addiction, metabolism & long-term health • How Timbaland stayed clean without rehab—and why relapse wasn’t an option We’d like to extend our gratitude to Eudēmonia for providing the opportunity to record with Timbaland at their event. Eudēmonia, created by the founders of Wanderlust Festival, is a premier health and well-being summit. You can learn more about their initiatives and upcoming events here: https://wanderlust.com/ Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Timbaland’s Website: https://www.timbaland.com/ • Timbaland’s Instagram : https://www.instagram.com/timbaland/?hl=en • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: -STEMREGEN | | Head to https://www.stemregen.co/dave for 20% off your first order. -Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. Timestamps: • 00:00 Trailer • 00:00 Introduction to the Human Upgrade • 00:09 Timbaland on Passion and Energy • 00:42 Balancing Passion and Avoiding Burnout • 02:04 Dreams and Manifestations • 04:51 Overcoming Addiction • 05:59 The Role of God in Recovery • 09:28 Helping Others with Addiction • 14:00 Weight Loss and Health Transformation • 16:29 Trusting Your Body’s Signals • 18:45 Skepticism About Modern Products • 21:10 Exploring Longevity and Individual Health • 22:23 The Intersection of Music and Spirituality • 25:56 Understanding Synesthesia and Its Impact • 27:41 The Journey to Weight Loss and Fitness • 35:08 The Importance of Sleep and Health • 37:23 Final Thoughts and Reflections See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Feb 40min

Gary Brecka: The SECRET Blood Marker That Could Save Your Life! (pt. 2)  : 1248

Gary Brecka: The SECRET Blood Marker That Could Save Your Life! (pt. 2) : 1248

Could the right form of a single vitamin be the difference between thriving and barely surviving? In this Part 2 conversation, human biologist and longevity expert Gary Brecka reveals the #1 overlooked factor that’s wrecking your health: methylation—your body’s ability to convert nutrients into fuel. If this process fails, your hormones, energy, and even mental health take a nosedive. Gary and Dave dive deep into the real cause of anxiety, ADHD, and mood disorders, the hidden genetic reason why diets fail, and why Big Pharma isn’t talking about this critical health breakthrough. Are you unknowingly setting yourself up for disease? What’s the simple fix that can reverse anxiety, gut problems, and even prevent genetic disease? And why is your doctor ignoring one of the biggest markers of longevity? What You’ll Learn: • The MTHFR gene mutation—and why it’s quietly affecting millions • Anxiety, ADHD, and depression—why these disorders start in your cells, not your brain • The gut-brain connection—how your microbiome controls your mood • Why your “healthy diet” might be hurting you (and what to eat instead) • How nutrient deficiencies are passed from mother to child—and how to stop it • The truth about homocysteine—the blood marker that could predict your lifespan • Why most people are living at 50% capacity—and how to get your energy back Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Gary Brecka’s Website: https://bit.ly/4hlfyti • Gary Brecka’s YouTube: https://bit.ly/3E3Aaba • Gary Brecka’s Instagram: https://bit.ly/3PNsgFe • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com • The Mold Movie!: https://moldymovie.com/ SPONSORS: -BON CHARGE | Go to https://boncharge.com/ and use coupon code DAVE to save 15%. -Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions. Timestamps: • 00:00 Trailer • 00:31 What Is Methylation? • 01:37 MTHFR, Folate & Your Health • 04:17 How Methylation Affects Disease • 06:41 Nutrient Deficiencies & Health Risks • 07:09 Why Blood Work Matters • 11:44 Homocysteine & Heart Health • 21:37 Catecholamines & Anxiety • 34:28 The Link Between Nutrients & Mood • 34:48 How Catecholamine Ratios Affect Mental Health • 35:39 Personal Health Struggles & Lessons • 36:25 The Role of Methylation in Wellness • 37:57 Methylation & Relationship Dynamics • 39:49 Hidden Dangers of Mold Toxicity • 52:55 Hydrogen Water for Health • 01:01:19 Mitochondria’s Role in Longevity • 01:02:23 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Feb 1h 2min

Gary Brecka: The World Is KILLING You—Use AI To Restore Testosterone, Energy & Longevity (Pt. 1) : 1247

Gary Brecka: The World Is KILLING You—Use AI To Restore Testosterone, Energy & Longevity (Pt. 1) : 1247

Why were our grandparents stronger, healthier, and living longer—without the “advancements” of modern medicine? Gary Brecka, one of the world’s leading experts in human longevity and performance, exposes the hidden crisis that’s wrecking your hormones, slashing your energy, and cutting your lifespan short. In this no-holds-barred conversation with Dave Asprey, they break down the corporate greed, medical corruption, and environmental toxins designed to keep you sick, weak, and dependent. What’s really causing the testosterone collapse in men and women? How is AI changing the game for hormone optimization, biohacking, and personalized health? And why are we aging faster than ever—while Big Pharma profits? This first episode in a two-part series is a deep dive into hormone optimization, testosterone, cholesterol myths, longevity hacks, and the AI-driven future of health. What You’ll Learn: • Why testosterone levels are plummeting—and how to restore them naturally • The real reason life expectancy is dropping (hint: it’s not just diet) • The Kellogg conspiracy—how food was designed to lower libido & testosterone • Why mainstream medicine is failing you (and what to do instead) • How AI and big data are rewriting the rules of health & longevity in• The shocking truth about cholesterol, heart disease, and pharmaceuticals • Why functional medicine & biohacking hold the key to real health optimization Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Gary Brecka’s Website: https://bit.ly/4hlfyti • Gary Brecka’s YouTube: https://bit.ly/3E3Aaba • Gary Brecka’s Instagram: https://bit.ly/3PNsgFe • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%. Timestamps: • 00:00 – Trailer • 00:42 – Introduction to The Human Upgrade • 01:35 – Meet Gary Brecka • 03:32 – Performance vs. Longevity • 06:16 – The Importance of Testosterone • 15:11 – Historical Hormone Levels • 18:00 – Population Averages in Health • 18:51 – The Flaws of Grading on a Curve • 20:35 – Corporate Influence on Health • 21:04 – The Danger of Cumulative Dosage • 22:20 – Social Media & Public Perception • 25:19 – Independent Research Matters • 32:21 – Big Data & AI in Health • 36:02 – The Future of Personalized Medicine • 36:49 – Conclusion & Teaser for Part Two See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Feb 37min

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