10-Minute Weekly Update : 1335

Upgrade your week in just 10 minutes with D(AI)ve Asprey’s essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. Each story includes trusted source links—so you can check the facts.


This episode covers:


- Rapamycin’s Reality Check:

A sweeping new review (September 24) finds that the promise of rapamycin for longevity in healthy adults is still weak and inconsistent. Dave shares why lifestyle levers (fasting, protein timing, smart training) come first, and any rapamycin experiment should be clinician-guided and tracked with labs.

Source: Aging-US press release – September 24, 2025 and EurekAlert science brief – September 24, 2025


- Senolytics Get Precise:

New research (September 23) shows that not all “zombie cells” (senescent cells) are equal in how they respond to anti-aging drugs—so future protocols will be timed and typed, not one-size-fits-all.

Source: Aging-US research stream – September 23, 2025


- AI Healthcare: Promise and Pause:

The latest market outlook (September 23) says AI in healthcare is surging toward a $100B+ market by 2030, but 70% of doctors still want humans in the loop for diagnosis. Dave shares how to use AI as your copilot—not your captain.

Source: Crescendo.ai – September 23, 2025


- Medical Policy Meets Machine Logic:

A new federal pilot now lets AI approve or deny Medicare coverage, possibly cutting off therapies before a human review happens. Dave explains how to demand explainability, fair appeals, and human override to protect access.

Source: KFF Health News policy rundown – September 25, 2025


- Longevity Headlines You Can Use:


  • Forest bathing wins renewed praise for helping with blood pressure and stress.
  • Northwestern’s SuperAger project links strong social ties to resilient brain health.
  • Human trials now test an antibody therapy to regrow lost teeth.


Source: XandroLab Longevity Roundup – Week of Sept 22–25, 2025


Action steps for the week:

  • Try fasting windows and smart protein clustering for mTOR modulation.
  • Let AI help summarize your health data—but get decisions confirmed by your clinician.
  • If you or your family touch Medicare, keep thorough documentation and demand human review.
  • Soak in green spaces, reconnect socially, and watch for cutting-edge therapies.


All source links provided for easy reference to the original reporting and research above.

This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Rapamycin, mTOR modulation, longevity, biohacking, senolytics, zombie cells, AI healthcare, Medicare coverage, human trials, forest bathing, SuperAger, brain health, fasting, protein cycling, medical freedom, anti-aging, personalized medicine, health tech, Dave Asprey, Human Upgrade podcast


Thank you to our sponsors!



Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Intro

0:18 — Rapamycin Hype Check

1:07 — Senolytics Leveled Up

2:41 — AI in Healthcare

3:11 — AI Between You and Your Doctor

5:50 — Three Longevity Angles

7:59 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Avsnitt(1437)

#53 Raw Vegan to Bulletproof Meat Eater - a beneficial transformation, with Kristen 'Raw' Suzanne

#53 Raw Vegan to Bulletproof Meat Eater - a beneficial transformation, with Kristen 'Raw' Suzanne

This episode brings to light an ex-vegan advocate’s journey to eating a mostly meat-embraced Bulletproof diet. Kristen ‘Raw’ Suzanne, author, popular blogger, and nutrition researcher, shared her former vegan assumptions, how easy or difficult it was to change, and the ethics of food. We also dove into a detailed conversations about liver meat, fertility issues on a vegan diet, how to stay Bulletproof when traveling with family, and how to nourish your kids the best way possible. In 2005, Kristen walked away from her corporate career in executive-level operations to focus on her true passion: healthy food. Already a vegan for two years, she turned her attention to the raw vegan cuisine and lifestyle, initially teaching classes and providing personal chef services, but as her online audience grew, she ultimately shifted to full-time blogging, recipe development, and eventually publishing 12 books on raw vegan diets. By 2012, concerns with her and her child's health forced her to reevaluate the nutritional claims made by advocates of raw and vegan diets. After Kristen introduced high quality animal products into her family's diet, she saw dramatic improvements almost immediately. Her family now eats a diet high in grass-fed beef and butter, bison, pastured eggs, and wild-caught seafood, while avoiding grains, gluten, and soy. While her personal transformation and conversion from vegan to omnivore has been controversial in the vegan and raw food community, Kristen has been on hiatus from blogging to spend time researching and fully exploring the nutritional and culinary aspects of eating in this new way for her family. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Aug 201357min

#52 – Sex, Sex Culture & Sex at Dawn with Christopher Ryan - Podcast

#52 – Sex, Sex Culture & Sex at Dawn with Christopher Ryan - Podcast

Welcome to our first ever VIDEO and audio podcast, where we’re celebrating by exploring everyone’s favorite topic – sex! This episode, with co-author of New York Times best seller, Sex at Dawn: How We Mate, Why We Stray, and What it Means for Modern Relationships, Christopher Ryan, gives you a peak into the evolutionary view of human sexual behavior. Sex at Dawn shatters myths surrounding the societal history behind how men and women interact in sexual relationships. Christopher made for a great interview, as he continues to rustle feathers around the ideas of traditional relationships.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Juli 201353min

#51 Transhumanism, Technology & the Future with Natasha Vita-More

#51 Transhumanism, Technology & the Future with Natasha Vita-More

This episode stretches the boundaries of biohacking by looking at the futurist ideology and movement called transhumanism. Natasha Vita-More, an American designer, theorist and author, joined me on this episode to discuss the possible transformation of the human condition by developing technologies that enhance intellectual, physical, and psychological capacities.  Natasha Vita-more is co-editor and author of The Transhumanist Reader: Classical and Contemporary Essays on the Science, Technology and Philosophy of the Human Future and designer and author of "Primo Posthuman," a pioneering future whole body prototype. Vita-More is a professor at the University of Advancing Technology, and a Fellow of the Institute for Ethics and Emerging Technologies and the Hybrid Reality Institute. She is currently Chairman of the Board of Directors of Humanity+. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Juli 201349min

#50 New Bulletproof iPhone App, Food Sensitivities & HRV with Ronda Collier from SweetWater Health

#50 New Bulletproof iPhone App, Food Sensitivities & HRV with Ronda Collier from SweetWater Health

The 50th episode of Bulletproof Executive Radio introduces you to a brand new free iPhone app called Bulletproof(R) Food Sense and to the scientist who made it all happen.  Today’s interview is with long time biohacker and founder of Sweetwater Health™, Ronda Collier. Ronda is putting her more than 25 years of experience in high tech to work at SweetWater Health™, where they are looking at the signal coming from the human heart, and instead of seeing beats per minute or simple heart rate variability, seeing a huge pool of big data just waiting to be analyzed using Ronda’s crazy advanced math skills. There is a lot more information in your heartbeat than you’d think – stress levels are just the beginning. By applying mobile health monitoring and stress management with medical research techniques, SweetWater Health is creating some very advanced, very easy to use biohacking technologies. My experience as a bio hacker who used to weigh 300 pounds and really struggled with food cravings, is that every single person has a set of things in their environment or their food that makes them weak. SweetWater Health and Bulletproof Executive just partnered to create the free Bulletproof(R) Food Sense iPhone app to help you find your personal kryptonite by using the phone’s onboard sensors to detect your hidden food sensitivities.   You can also get an amazingly full-featured version of the app that works with a chest strap to measure and track your heart rate variability all day long and use complex algorithms to quantify your food, stress, and overall health. Click here to download your free Bulletproof Food Sense app from the Apple iTunes store. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Juli 201348min

#49 Q & A Eggs, Butter & Zen - Podcast

#49 Q & A Eggs, Butter & Zen - Podcast

About once a month, I set aside a whole podcast to answer questions from the Bulletproof community. It's all about answering your very best questions, sourced from e-mail, Facebook, Twitter, the Bulletproof forum and the blog! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Juli 201359min

#48 “Fat Burning Man,” Abel James and Bulletproof Exec Unite

#48 “Fat Burning Man,” Abel James and Bulletproof Exec Unite

This podcast is with Abel James – a #1 best-selling author, fat loss coach, musician, radio show host, and veritable health crusader. Abel also runs the extremely popular “Fat Burning Man” show – which is one of the top health podcasts on iTunes.  A former strategic advisor to the food and beverage industry, Abel now acts as a consumer advocate who exposes the truth behind deceptive marketing practices, misleading corporate propaganda, and powerful special interests that have accelerated the worldwide obesity epidemic and health crisis. Abel harnesses the techniques he developed for the Lean Body System to achieve extremely compelling results in fat loss and health for his clients and the community. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Juli 201356min

#47 Biohacking Cows, Bulletproof Dairy and Probiotics with Natural Health Expert, Jordan Rubin

#47 Biohacking Cows, Bulletproof Dairy and Probiotics with Natural Health Expert, Jordan Rubin

Jordan Rubin is one of America’s most recognized and respected natural health experts. He is the author of the New York Times best selling book, The Maker’s Diet, as well as the author of 19 other health related titles, including his latest work Perfect Weight America. An international motivational speaker, Jordan hosts the weekly television show Extraordinary Health that reaches more than 30 million households worldwide. He is Founder and CEO of Garden of Life, a leading health and wellness company committed to empowering extraordinary health with whole food based supplements, functional foods, and founder of Beyond Organic. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Juni 201349min

#46: Reichart Von Wolfsheild - Bulletproof Your Systems

#46: Reichart Von Wolfsheild - Bulletproof Your Systems

Reichart Von Wolfsheild, is a co-host on History Channel’s Invention USA.  He is a technologist, inventor, artist and futurist. Starting in his teens, he designed and built a computer CPU from scratch. In the early 1980s, while helping pioneer music videos for the then-fledgling network, MTV, he started his first successful technology company developing Artificial Intelligence applications. Blending his talents from several fields he made history conceiving one of the first multi-player modem video games, kicking off a franchise. He has designed everything from toys to weapons and developed more than 120 products for companies such as Boeing, Disney, Dreamworks and Mattel, and is always looking for the next fun challenge. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Juni 201346min

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