10-Minute Weekly Update : 1335

Upgrade your week in just 10 minutes with D(AI)ve Asprey’s essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. Each story includes trusted source links—so you can check the facts.


This episode covers:


- Rapamycin’s Reality Check:

A sweeping new review (September 24) finds that the promise of rapamycin for longevity in healthy adults is still weak and inconsistent. Dave shares why lifestyle levers (fasting, protein timing, smart training) come first, and any rapamycin experiment should be clinician-guided and tracked with labs.

Source: Aging-US press release – September 24, 2025 and EurekAlert science brief – September 24, 2025


- Senolytics Get Precise:

New research (September 23) shows that not all “zombie cells” (senescent cells) are equal in how they respond to anti-aging drugs—so future protocols will be timed and typed, not one-size-fits-all.

Source: Aging-US research stream – September 23, 2025


- AI Healthcare: Promise and Pause:

The latest market outlook (September 23) says AI in healthcare is surging toward a $100B+ market by 2030, but 70% of doctors still want humans in the loop for diagnosis. Dave shares how to use AI as your copilot—not your captain.

Source: Crescendo.ai – September 23, 2025


- Medical Policy Meets Machine Logic:

A new federal pilot now lets AI approve or deny Medicare coverage, possibly cutting off therapies before a human review happens. Dave explains how to demand explainability, fair appeals, and human override to protect access.

Source: KFF Health News policy rundown – September 25, 2025


- Longevity Headlines You Can Use:


  • Forest bathing wins renewed praise for helping with blood pressure and stress.
  • Northwestern’s SuperAger project links strong social ties to resilient brain health.
  • Human trials now test an antibody therapy to regrow lost teeth.


Source: XandroLab Longevity Roundup – Week of Sept 22–25, 2025


Action steps for the week:

  • Try fasting windows and smart protein clustering for mTOR modulation.
  • Let AI help summarize your health data—but get decisions confirmed by your clinician.
  • If you or your family touch Medicare, keep thorough documentation and demand human review.
  • Soak in green spaces, reconnect socially, and watch for cutting-edge therapies.


All source links provided for easy reference to the original reporting and research above.

This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Rapamycin, mTOR modulation, longevity, biohacking, senolytics, zombie cells, AI healthcare, Medicare coverage, human trials, forest bathing, SuperAger, brain health, fasting, protein cycling, medical freedom, anti-aging, personalized medicine, health tech, Dave Asprey, Human Upgrade podcast


Thank you to our sponsors!



Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Intro

0:18 — Rapamycin Hype Check

1:07 — Senolytics Leveled Up

2:41 — AI in Healthcare

3:11 — AI Between You and Your Doctor

5:50 — Three Longevity Angles

7:59 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Avsnitt(1436)

Bonus: Client Review with Jonathan Kos

Bonus: Client Review with Jonathan Kos

Jonathan Kos is an IT professional and a recent follower of the Bulletproof Diet.  He is a 44 year old IT professional . At 6' 3" and a former college athlete that played football, competitive ice hockey up until the age of 25 he was an extremely fit 220 lbs and my coaches wanted me up to 275 or so to play the defensive line so I was eating literally non stop to put weight on. After college he dropped down to around 200 lbs and eventually settled at for me was a healthy 235.  As he got older and more settled in his job, his weight climbed and he couldn’t keep his weight in check with exercise alone and he started to have to diet he was up to 300 lbs and was exercising more that ever but the weight didn’t come off. After he met his wife, exercise was out the window, a carb heavy diet was in, and his weight ballooned up to 365lbs. He was about to give up until he heard Tait Fletcher on Joe Rogan's podcast mentioning Bulletproof ® Coffee and he gave it a shot. He lost 45lbs in 45 days, and is here to share his experience with you.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Juni 201311min

#44: Salt and self-experimentation with Greg Pomerantz

#44: Salt and self-experimentation with Greg Pomerantz

For Greg Pomerantz everything is a science experiment. He takes citizen science to a personal level by biohacking his blood pressure and detailing his data. He blogged about his self-experiment research on salt clarifying some concerns he had about salt’s effect on the body. He determined what his salt type is, either one is salt sensitive, or one that isn’t affected much by increases in salt. He discusses how to do that in today’s podcast. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Juni 201337min

#43: Kelly Starrett, Mobility and Performance

#43: Kelly Starrett, Mobility and Performance

Coach Kelly Starrett received his Doctor of Physical Therapy in 2007 from Samuel Merritt College in Oakland, California. He currently runs his own physical therapy practice at San Francisco CrossFit—one of the first 50 CrossFit affiliates—and focuses on performance-based Orthopedic Sports Medicine with an emphasis on returning athletes to elite level sport and performance. His clients see exceptional results from his progressive blend of manual physical therapy and strength training. Since 2009, Kelly has been traveling the country teaching his "Movement, Mobility & Maintenance Course" in an effort to spread his message that good mobility and proper movement are the keys to good performance and that all humans should be able to perform this basic maintenance on themselves. Kelly's clients have included Olympic gold-medalists, Tour de France cyclists, world-class extreme skiers and X-Games medalists, dancers with Smuin, San Francisco, and Sacramento Ballet Companies, military personnel, and competitive age-division athletes. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Maj 201350min

#42: Alderspring's Glenn Elzinga, Grass-Fed Beef and a Bulletproof Protein

#42: Alderspring's Glenn Elzinga, Grass-Fed Beef and a Bulletproof Protein

With training in forestry and forest ecology, Glenn Elzinga began his forestry career in Maine. In the mid 1980s, he moved to Salmon, Idaho where he worked as District Forester for the Salmon BLM for over a decade. As his family began to grow, he realized he wanted a better way to raise kids than leaving them for work all day. So began his current career in ranching. After ranching for 17 years, Glenn's cattle herd has grown from 7 head to over 600. He keeps his hand in forestry by working with his wife, Caryl, on consulting projects and by horse-logging occasionally with his two Belgian mares, Pet and Pat. He hopes to train his new draft Suffolk geldings, Red and Snap, to log as well. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Maj 201350min

#41: Jason Nunnelley, Self Tracking

#41: Jason Nunnelley, Self Tracking

Jason Nunnelley’s work is focused on application and systems development. After his first company sold in 2000, he spent his time helping small business capitalize on Internet technologies. He is presently dedicated to dosIQ, Inc., a Wellness Journal and set of apps designed to make self-tracking and health monitoring simple for anyone. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Apr 201358min

#40: Dan John, Brains & Brawn

#40: Dan John, Brains & Brawn

Dan John has spent his life with one foot in the world of lifting and throwing, and the other foot in academia. An All-American discus thrower, Dan has also competed at the highest levels of Olympic lifting, Highland Games and the Weight Pentathlon, an event in which he holds the American record. Dan spends his work life blending weekly workshops and lectures with full-time writing, and is also an online religious studies instructor for Columbia College of Missouri. As a Fulbright Scholar, he toured the Middle East exploring the foundations of religious education systems. His books, on weightlifting, include Intervention, Never Let Go, Mass Made Simple and Easy Strength, written with Pavel Tsatsouline as well as From Dad, To Grad. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Mars 201358min

#39: Hormone Alchemy (+ Why Hard Data is HOT)... How to Amplify the Positive Neuro-hormonal Dashboard with Dr. Sara Gottfried MD

#39: Hormone Alchemy (+ Why Hard Data is HOT)... How to Amplify the Positive Neuro-hormonal Dashboard with Dr. Sara Gottfried MD

Dr. Sara Gottfried is a Harvard doc, biohacker, and yoga-powered champion of your health, happiness and hormonal equilibrium. She’s also seen 20,000 patients in the past 20 years and applied her training as a MIT bioengineer to how women and men can leverage the upstream and downstream mediators to create natural hormone balance with next gen medicine, and wrote a book about it, called The Hormone Cure: Reclaim Balance, Sleep, Sex Drive, and Vitality Naturally with The Gottfried Protocol (Simon & Schuster, 3/12/13) She biohacked her own happy hormones and happy brain chemicals as a 30-something stress case battling McMedicine, PMS, and low sex drive. She was offered Prozac and a birth control pill for her misery by her primary care physician, and that was a defining moment that allowed her to step from her darkest hour into the grace of biohacking bliss. The main culprit: CORTISOL. It took her 4 weeks to get her crazy-high cortisol down to the Goldilocks position of not too high and not too low, and she applied that learning and refined her protocol on her next 10,000 patients over the next 10 years. Results were staggering: Dr. Sara could neutralize cortisol, what she calls the “bad-boyfriend” hormone in 1 minute. She reversed insulin resistance in 48 hours. She got estrogen back into it’s rightful place, and thyroid, inside of 2 weeks. She believes knowledge is power, science is sexy... and, oh yes, actionable needle-moving solutions are hot. Listen in for our dialogue about cutting-edge science, and crazy-lovin’ solutions -- for men and women. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Mars 20131h 4min

#38: Mark Divine, Bulletproof Warrior and SEALFIT's founder

#38: Mark Divine, Bulletproof Warrior and SEALFIT's founder

Mark Divine is from upstate New York and did his formal undergraduate education at Colgate University. His years at Colgate University were focused on the athletic endeavors of competitive swimming, rowing and triathlon racing. Mark pursued a Ph.D. in Leadership at the University of San Diego and served as an Adjunct Professor of Leadership in their undergraduate school. The Doctorate was interrupted by a one-year recall to active duty for Operation Iraqi Freedom. The recall took him to Baghdad in 2004 with SEAL Team One to conduct a special project studying the future role of the USMC in the Special Operations Command. Upon his return home he left USD to focus on developing SEALFIT and put his Unbeatable Mind training philosophy to work on a new generation of Special Ops candidates. You will learn all about this amazing program and more in this exclusive interview! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Mars 201355min

Populärt inom Utbildning

rss-bara-en-till-om-missbruk-medberoende-2
historiepodden-se
det-skaver
alska-oss
nu-blir-det-historia
johannes-hansen-podcast
harrisons-dramatiska-historia
sektledare
allt-du-velat-veta
not-fanny-anymore
roda-vita-rosen
rss-makabert
rss-sjalsligt-avkladd
dumforklarat
rss-max-tant-med-max-villman
sa-in-i-sjalen
rikatillsammans-om-privatekonomi-rikedom-i-livet
sex-pa-riktigt-med-marika-smith
sektpodden
rss-npf-podden