#633: Chris Palmer, MD, of Harvard Medical School — Optimizing Brain Energy for Mental Health, The Incredible Potential of Metabolic Psychiatry, Extraordinary Case Studies, and Harnessing Mitochondria for Anxiety, Depression, OCD, PTSD, and More

#633: Chris Palmer, MD, of Harvard Medical School — Optimizing Brain Energy for Mental Health, The Incredible Potential of Metabolic Psychiatry, Extraordinary Case Studies, and Harnessing Mitochondria for Anxiety, Depression, OCD, PTSD, and More

Brought to you by Levels real-time feedback on how diet impacts your health, Athletic Greens all-in-one nutritional supplement, and LinkedIn Marketing Solutions marketing platform with 800M+ users.

Dr. Christopher M. Palmer (@chrispalmermd) is a Harvard psychiatrist and researcher working at the interface of metabolism and mental health.

Dr. Palmer is the director of the Department of Postgraduate and Continuing Education at McLean Hospital and an assistant professor of psychiatry at Harvard Medical School. For over 25 years, he has held administrative, educational, research, and clinical roles in psychiatry at Harvard. He has been pioneering the use of the medical ketogenic diet in the treatment of psychiatric disorders—conducting research in this area, treating patients, writing, and speaking around the world on this topic.

He has developed the first comprehensive theory of what causes mental illness, integrating existing theories and research into one unifying theory—the brain energy theory of mental illness. You can learn more in his new book Brain Energy: A Revolutionary Breakthrough in Understanding Mental Health—and Improving Treatment for Anxiety, Depression, OCD, PTSD, and More.

Please enjoy!

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This episode is brought to you by Athletic Greens. I get asked all the time, “If you could use only one supplement, what would it be?” My answer is usually AG1 by Athletic Greens, my all-in-one nutritional insurance. I recommended it in The 4-Hour Body in 2010 and did not get paid to do so. I do my best with nutrient-dense meals, of course, but AG further covers my bases with vitamins, minerals, and whole-food-sourced micronutrients that support gut health and the immune system.

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This episode is also brought to you by LinkedIn Marketing Solutions, the go-to tool for B2B marketers and advertisers who want to drive brand awareness, generate leads, or build long-term relationships that result in real business impact.

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This episode is also brought to you by Levels! I wrote about the health benefits of using continuous glucose monitors (CGMs) more than ten years ago in The 4-Hour Body. At the time, CGMs were primitive and hard to use. Levels has now made this technology, and the unique insights that come from it, easy and available to everyone. Levels is making glucose monitoring simple, helping you see how food affects your health through real-time feedback. I started tracking my glucose years ago to learn more about what I should and shouldn’t be eating (including quantities, time of day, etc.), based on objective data from my own, unique physiology. Keeping my blood sugar stable is critical to my daily and long-term health and performance goals. Furthermore, poor glucose control is associated with a number of chronic conditions like diabetes, Alzheimer’s disease, heart disease, and obesity. It’s important.

If you’re interested in learning more about Levels and trying a CGM yourself, go to Levels.link/Tim.

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[07:14] How a woman overcame her 53-year streak of chronic paranoid schizophrenia.

[11:16] The backstory of Brain Energy‘s dedication.

[16:31] Chris’ thoughts on DSM-5 diagnostic categories.

[21:51] Chris’ first exposure to the ketogenic diet.

[28:35] Metabolic psychiatry.

[30:33] How ketosis affects the human body (e.g., sleep, mood, weight).

[39:35] Examining the mood elevation of ketosis on a bio-cellular level.

[44:24] When ketosis can be dangerous.

[46:44] How mitochondrial dysfunction can trigger a host of ailments.

[58:07] Dietary methods for sustaining ketosis over the long term.

[1:04:54] Common ketosis mistakes.

[1:07:53] Psychiatric medications, metabolism, and controversy.

[1:15:29] Indications that a medication impairs more than improves a patient’s condition.

[1:18:06] Resources to share with doctors open to conversation about these issues.

[1:20:41] Why quitting psychiatric medication cold turkey is a bad idea.

[1:23:20] Thoughts on the efficacy of exogenous ketones.

[1:30:32] Ketogenic diet as treatment for schizophrenia.

[1:38:34] Why you need to take radical ownership of your own health advocacy.

[1:40:33] Physical exercise for optimizing mitochondrial health.

[1:44:59] A cautionary note for people using medication for off-label results.

[1:48:49] Parting thoughts.

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For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.

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Avsnitt(859)

#831: Frank Miller, Comic Book Legend — Creative Process, The Dark Knight Returns, Sin City, 300, and Much More

#831: Frank Miller, Comic Book Legend — Creative Process, The Dark Knight Returns, Sin City, 300, and Much More

Frank Miller is regarded as one of the most influential and awarded creators. He began his career in comics in the late 1970s, first gaining notoriety as the artist, and later writer, of Daredevil for...

20 Okt 20251h 32min

#830: Nick Kokonas and Richard Thaler, Nobel Prize Laureate — Realistic Economics, Avoiding The Winner’s Curse, Using Temptation Bundling, and Going Against the Establishment

#830: Nick Kokonas and Richard Thaler, Nobel Prize Laureate — Realistic Economics, Avoiding The Winner’s Curse, Using Temptation Bundling, and Going Against the Establishment

Richard H. Thaler is the 2017 recipient of the Nobel Memorial Prize in Economic Sciences for his contributions to behavioral economics and the Charles R. Walgreen Distinguished Service Professor of Be...

10 Okt 20251h 57min

#829: James Nestor — Breathing Protocols to Reboot Your Health, Fix Your Sleep, and Boost Performance

#829: James Nestor — Breathing Protocols to Reboot Your Health, Fix Your Sleep, and Boost Performance

James Nestor is a science journalist and the author of the international bestseller Breath: The New Science of a Lost Art, with more than three million copies sold in 44 languages.This episode is brou...

30 Sep 20251h 50min

#828: David Senra — How Extreme Winners Think and Win: Lessons from 400+ of History’s Greatest Founders and Investors (Including Buffett, Munger, Rockefeller, Jobs, Ovitz, Zell, and Names You Don’t Know But Should)

#828: David Senra — How Extreme Winners Think and Win: Lessons from 400+ of History’s Greatest Founders and Investors (Including Buffett, Munger, Rockefeller, Jobs, Ovitz, Zell, and Names You Don’t Know But Should)

David Senra is the host of the Founders podcast. For the past nine years, David has intensely studied the life and work of hundreds of history’s greatest entrepreneurs. His new podcast, David Senra, s...

24 Sep 20252h 55min

#827: Pablos Holman — One of The Scariest Hackers I’ve Ever Met

#827: Pablos Holman — One of The Scariest Hackers I’ve Ever Met

Pablos Holman is a hacker and inventor and the author of Deep Future: Creating Technology that Matters, the indispensable guide to deep tech. Previously, Pablos worked on spaceships at Blue Origin and...

16 Sep 20252h 31min

#826: Q&A with Tim — Supplements I’m Taking, Austin vs. SF, Training for Mental Performance, Current Go-To AI Tools, Recovering from Surgery, Intermittent Fasting, and More

#826: Q&A with Tim — Supplements I’m Taking, Austin vs. SF, Training for Mental Performance, Current Go-To AI Tools, Recovering from Surgery, Intermittent Fasting, and More

This episode is a solo Q&A session where I answer a bunch of questions. We covered a ton of ground, from personal health protocols to professional frameworks and creative projects. This episode is bro...

9 Sep 20251h 25min

#825: Dr. Dominic D’Agostino — All Things Ketones, How to Protect the Brain and Boost Cognition, Sardine Fasting, Diet Rules, Revisiting Metformin and Melatonin, and More

#825: Dr. Dominic D’Agostino — All Things Ketones, How to Protect the Brain and Boost Cognition, Sardine Fasting, Diet Rules, Revisiting Metformin and Melatonin, and More

Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and...

3 Sep 20251h 54min

#824: What Most Has My Attention Right Now — Credible (vs. Bogus) Vagus Nerve Stimulation

#824: What Most Has My Attention Right Now — Credible (vs. Bogus) Vagus Nerve Stimulation

Kevin J. Tracey, MD is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of the recent book, The Great Nerve: The New...

26 Aug 20252h 23min

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