Peak Human - Unbiased Nutrition Info for Optimum Health, Fitness & Living3 Apr 2019

Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Dr. Thomas Seyfried is a Professor of Biology at Boston College, and received his Ph.D. in Genetics and Biochemistry from the University of Illinois. He then worked as an assistant professor in the neurology department at the Yale school of medicine. He has over 180 peer-reviewed publications and is author of the book, Cancer as a Metabolic Disease. He recently received a Lifetime Achievement Award from the Academy of Complimentary and Integrative Medicine.

I got a chance to meet and interview him at the Metabolic Health Summit earlier this year. You'll notice we did this podcast shortly after the Super Bowl. In case people aren't familiar with American football the New England Patriots had just beaten the LA Rams.

I hope people look up the paper he recently published that we mention and watch his presentation I linked to in the show notes and go deeper on this topic. It's very surprising to learn of this completely new view on cancer if you haven't heard of it before. This really shouldn't be very surprising to anyone, however, because of course our modern diet and lifestyle would have the biggest effect on the rising cancer rates. And of course fixing these things would also be a major part of the treatment. He's really doing legendary work. So without further ado, here's professor Seyfried.

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Show Notes

Dr. Thomas Seyfried believes cancer is a metabolic disease, not a genetic disease and explains in simple terms why that is
The mitochondria in your cells make energy (ATP)
There's 2 types of energy: ancient energy which is a fermentation metabolism which means you can make energy without oxygen, or respiration where you make energy from breathing air
Cancer cells ferment - therefore they don't use oxygen
Not all cancer cells have genetic mutations, but all cancer cells ferment
The mitochondrial metabolic theory says that the organelle that makes energy from respiration is defective, forcing the cell to ferment. When the cell ferments, mutations collect in the nucleus
This means the genetic mutations seen in cancer cells come from a downstream effect of disruption of energy metabolism
The cancer cell has to consume a large amount of glucose and the amino acid glutamine in order to survive on a fermentation metabolism
On the other hand, normal cells use oxygen and very little amounts of glucose
This should make sense to a lot of people because they've probably heard cancer cells need a lot of glucose and if you starve them of that they die
Have to re-emphasize the fact that the DNA damage comes as a downstream effect
Damaged mitochondria, instead of making ATP, make Reactive Oxygen Species (ROS) or oxidative stress (which causes a lot of problems in our body)
The oxidative stress also causes damage to the nucleus and the genome
The field of cancer research studies effects instead of causes
We're not treating cancer by looking at the root cause - it's absurd - how would we ever cure it?
This is supported by thousands of experiments and studies
Obvious step to treat cancer is to deprive the cancer cells of glucose and glutamine and transition healthy cells into the use of ketones which they can readily use
We evolved as a starving creature and convert fatty acids into ketones and usable forms of energy
Cancer cells can't use ketones
There's no dietary way to restrict glutamine to the cancer cells so drugs have to be used
Basically nobody he's heard of is treating it this way
If it's so clear this is how cancer works, why has this not reached the mainstream?
The Federal government puts out websites saying cancer is genetic, medical schools teach it's genetic, leading cancer clinics tell patients it's genetic
Entrenched beliefs continue this. Also funding money is all based around the genetic theory
If you look at the mitochondria of any cancer cell under an electron microscope you can easily see the damage to the organelles and mitochondria
Cancer is a result of the industrialization as a society
Cancer is so rare throughout history or with non-industrialized societies they don't even have the word for it in their language
Cancer comes from all kinds of things like pollution, chemicals, radiation, hypoxia, infections, chronic inflammation, even some rare inherited diseases like BRCA1 (but it has to damage the mitochondria)
These are all secondary - the root cause is damage to the respiration
Obese people have higher rates of cancer and also higher inflammation (measured by C reactive protein)
To avoid cancer it's as simple as avoiding diets and lifestyles that risk damage to the mitochondria
Metabolic therapies need to at least be options for people
Problem is doctors aren't aware of them or aren't trained on them
Therapeutic ketosis is a medicine - it's different than just a diet (which is a turn-off to a lot of medical professionals)
There's therapeutic weight loss and toxic weight loss
Using a suite of therapies to cure cancer including ketogenic metabolic therapy and hyperbaric oxygen therapy
Hyperbaric oxygen creates reactive oxygen species that kills cancer cells but healthy cells using ketones are protected from oxidative stress and are fine
Burning ketones creates less ROS (which is a good thing) and is why many people without cancer eat a ketogenic diet
ROS damages tissues and is why you age
He published the glucose-ketone index calculator
People need to realize sweets are a treat once in awhile - not an everyday thing
The food industry has played into our ancient desires for sweet
Otto Warburg studied cancer in the early 1900s
He found that cancer cells would grow in an 100% oxygen environment - they continue to ferment and create lactic acid
Because their mitochondria are defective they can't switch back to oxidative phosphorylation
He recently published a paper filling in the gaps from Otto Warburg's work
Missing link was the glutamine that cancer cells can also use
Have to pulse the glutamine so the immune system can do it's job and clear out the dead cells
He's developed the press-pulse system in his lab to attack tumors strategically
Almost there with dosage, timing, and schedule - when done with this will have the pathway to resolution
He's having trouble getting funding for this for some reason
One problem is people have created separate little communities and foundations around their specific type of cancer even though they all have the common metabolic foundational problem
People are going to have to participate in the management of their disease and the culture of the diseases has to change
Another problem is the high cost of these standard therapies - people have to pay $400k
His paper looking at research conducted on cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/
If you take a normal cytoplasm and implant a nucleus with a tumor you get normal cells. But if you implant a normal nucleus to a cell with damaged cytoplasm, you get more tumor cells. This shows it's the damaged mitochondria in the cytoplasm, not the DNA in the nucleus
The wheelchair doesn't cause your legs to not work
Needle biopsies are putting people at risk and are pointless
He calls this general misunderstanding of cancer the biggest tragedy in the history of medicine
What do critics of his views say? They try to create doubt
They rely on private funding and some great organizations supporting this research
Travis Christofferson's foundation https://foundationformetaboliccancertherapies.com
His book Tripping Over the Truth https://www.amazon.com/Tripping-over-Truth-Overturning-Entrenched/dp/1603587292/
Dr. George Yu's foundation https://yufoundation.org
Presentation by Dr. Seyfried https://www.youtube.com/watch?v=APwnkpD_BfI&frags=pl%2Cwn
Dr. Seyfried's book https://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920/

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Part 187 - Miki Ben-Dor on Our Meat-Eating & Happiness Utopia Before Agriculture

Brian once again sits down with Miki Ben-Dor, a paleoanthropologist affiliated with Tel Aviv University. He specializes in the association between nutrition and evolution in humans, with a particular focus on reconstructing the Paleolithic diet. He conducted the study titled The evolution of the human trophic level during the Pleistocene (https://onlinelibrary.wiley.com/doi/full/10.1002/ajpa.24247) and is the author of the 2023 book Live Paleo Style which can be purchased on Amazon. GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES (06:47) The top two principles that the hunter-gatherers of the past lived by was autonomy and equality. (15:44) What most people call the "paleo diet", Miki simply calls our "natural diet". (31:24) Sharing is common in all nomadic hunter-gatherer societies. (46:14) Those who continue to push the high-fiber, low-meat lifestyle are doing so disingenuously. (1:15:40) Brian and Miki recap just a few pieces of evidence that humans evolved to be high-trophic-level carnivores that do best when they primarily consume meat and fat (1:30:00) Meaning is found in helping others. GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

8 Mars 20231h 48min

Part 186 - Dr. John Jaquish - Is Lifting Weights a Waste of Time?

Brian sits down with Dr. John Jaquish, the Wall Street Journal bestselling author of the book Weight Lifting Is A Waste Of Time, So Is Cardio, And There's A Better Way To Have The Body You Want! He developed OsteoStrong, a groundbreaking bone density building medical technology, and is now in partnership with Tony Robbins. He is also the inventor of the X3 Bar, which has been proven to develop muscle much faster than conventional weight lifting. Dr. Jaquish's methods have been used to train the world's most elite athletes, such as the entire Miami Heat organization, various NFL and NBA players, as well as Olympians. Use the promo code SAPIEN to get $50 off your X3 Bar at https://www.jaquishbiomedical.com/x3-bar/. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (12:05) According to Dr. Jaquish, 99% of people who go to the gym make no progress in their physique goals. (21:06) With variable resistance, you deal with more weight in positions where you are stronger, and dealing with less weight in positions where you are biomechanically inefficient. (28:06) For optimal muscle growth, you need a lot of protein in your system. Consuming up to 200 grams every day often makes it hard to eat anything else (i.e. carbs). (33:45) Metabolic rebound is the reason some muscle growth is associated with fasting, as demonstrated in a study conducted by Henry Alkire (https://www.linkedin.com/in/henry-alkire). (44:16) Supposedly, eating one meal per day puts you at higher risk of all-cause mortality. Dr. Jaquish finds a major flaw in the study (https://linkinghub.elsevier.com/retrieve/pii/S2212267222008747) which claims this. (47:06) A healthy heart is highly-dependent on testosterone. (56:40) Cardio is a waste of time. For full show notes with links to all the studies join the Patreon BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

28 Feb 20231h 10min

Part 185 - Layne Norton, PhD and The Great Diet Debate

Layne completed a BS in Biochemistry and a PhD in Nutritional Sciences, honing his intellectual skills under Dr. Donald Layman, one of the foremost researchers on protein metabolism and fat loss in the world. He has also enjoyed success in bodybuilding, winning a natural pro card in 2006. He is the founder of BioLayne. He created the company to provide ethical, science-based coaching that synthesized real world experience with evidence based protocols. In his coaching career he has turned over 70 people pro and reshaped the way that countless people think about nutrition. https://biolayne.com GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: (9:51) There is no "one-size-fits-all" prescription in the fitness and nutrition space. (19:50) There is no such thing as "good" and "bad" foods. (24:15) Nuance is king in the fitness and nutrition space. (31:36) Don't sweat the carb/fat debate. (49:01) Layne doesn't claim to be an arbiter of truth; but, he's all for intellectual honesty. (1:03:00) Brian and Layne debate on common points of contention in nutritional science. (1:22:30) It's much easier to live an unhealthy life today compared to just three decades ago. Learn more about the individuals and studies we mentioned in today's episode: Dr. Ted Naiman: https://www.dietdoctor.com/authors/dr-ted-naiman-md "Co-consumption of Vegetables and Fruit, Whole Grains, and Fiber Reduces the Cancer Risk of Red and Processed Meat in a Large Prospective Cohort of Adults from Alberta's Tomorrow Project": https://www.mdpi.com/2072-6643/12/8/2265 Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake: https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdf GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

15 Feb 20231h 36min

Part 184 - Dr. Scott Sherr on Optimizing Your Mitochondria For Peak Health

Dr. Scott Scherr is an Internal Medicine MD. CoFounder of OneBase health, COO of Troscriptions, and HOMe. A specialist in HBOT, Dr. Scott is interested in all things health/performance optimization. IG: https://www.instagram.com/drscottsherr/?hl=en Websites: https://linktr.ee/drscottsherr GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: Coming soon GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

8 Feb 20231h 29min

Part 183 - Dr. Molly Maloof on True Heath in the Modern World

Dr. Molly Maloof is a Healthspan Doctor, determined to maximize our potential with health optimization, biohacking, and personalized wellness. Founder of multiple wellness-focused organizations, and having served as medical advisor for a multitude of brands, she's on a mission to help us all live our best lives through education and health awareness. She is the author of Spark Factor: The Secret to Supercharging Energy, Becoming Resilient, and Feeling Better Than Ever which is now open for pre-order. Dr. Molly's Website: https://drmolly.co/ BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES 1:55 - Dr. Molly's background 4:25 - Healthspan and the role of Mitochondria 13:30 - Blood sugar and different carb types 17:30 - The myth of the Calories in/Calories out theory 20:37 - The truth of healthcare and predictions for the industry 27:42 - Trying to stay healthy in a new environment 30:40 - How is technology changing health? 34:00 - The role of social connection in living a healthy life. 37:35 - How to make friends and improve your network 42:20 - Dr. Molly's health journey and becoming a doctor 48:58 - How trauma affects our health and navigating sexual and relationship experiences 58:20 - Women's biohacking BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

1 Feb 20231h 16min

Part 182- Natalie Kovarik and Tara Vander Dussen - Is Walmart Beef & Milk Healthy?

Natalie Kovarik Natalie is a Ranch wife, mother, and social entrepreneur. She's grown from an instagram following to include her own podcast, clothing line, an online course, and she now hosts marketing retreats for women in rural lifestyles. Natalie's website: https://nataliekovarik.com Tara Vander Dussen Tara is a 5th generation dairy farmer, environmental scientist, farm wife, and mother to 2 girls. She serves as president of United Dairy Women, a charity dedicated to providing dairy to families in New Mexico. A passionate advocate for all things dairy farming. She's proudly known as the New Mexico Milkmaid when sharing online. Her mission is to share the truth about dairy farming and weed out the misconceptions about farming and farm life. Tara's Website: https://taravanderdussen.com/ Together with Tara they host the DiscoverAg podcast and help women with agriculture marketing with their Ecourses and Facebook community ElevateAg. GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES [4:28] - Nuances of the ranching solution. [8:00] - Types of ranching operations [11:15] - Breakdown of farm sizes and stats in the US [13:00] - Common misconception that cows spend their lives in cages [15:10] - Cattle are naturally herd animals, it gives off a misconception that they're always packed super close together when on pastures [17:53] - The majority of people have been fed the propaganda that meat is the enemy [21:00] - Are there bad players/practices in the industry? [28:40] There's a lot of arguments about how we get our food, but ultimately we still need some amount of efficiency for such large populations [34:45] How has the quality of milk/meat changed? Can cows actually eat corn and non-traditional diets. [39:52] Is marbled meat bad? [48:39] What are some of the differences in nutrition with lab grown meat? [53:10] - Is climate change a human cause? What's the truth? [59:29] Meat based diets are making a comeback and gaining traction over veganism. GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

26 Jan 20231h 13min

Part 181 - Elliot Overton on 2 Huge Nutrition Aspects That Could Change Your Health

After developing some minor health issues of his own after an extended back-packing trip through Asia, Elliot decided to take responsibility and began researching ways by which he could find resolution without the use of pharmaceutical medications. Elliot soon discovered that the solution to his problems was rooted in nutrition and basic lifestyle principles. Elliot's experience, and the experience of those close to him, demonstrated the power of nutritional intervention. Elliots success in improving his own health journey inspired him to study nutrition at a professional standard so that he could go on to help others along the way. Elliot trained as a nutritional therapist at the College of Naturopathic Medicine in the UK, and later gained a qualification in Functional Medicine. https://www.eonutrition.co.uk/ BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES 01:20 How Elliot got interested in thiamine 06:50 Are you getting enough Thiamine When animals were given large doses of thiamine before being exposed to head trauma, it was shown to mitigate many of the negative ramifications of the head injury, and allow for normal functions to be carried out at a greater rate than the control group. https://www.sciencedirect.com/science/article/pii/S0005272818301208 Very high doses of B1 have been found to completely abolish symptoms of Alzheimer's disease. https://www.hormonesmatter.com/new-developments-in-high-dose-thiamine-the-legacy-of-antonio-costantini/ Large doses of thiamine have also demonstrated two almost completely abolished symptoms of fibromyalgia seemingly overnight. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669831/#:~:text=Some%20observations%20indicate%20that%20the,mitochondria%20or%20to%20enzymatic%20abnormalities. 21:20 Why don't more people know about thiamine? 38:00 Oxalates and thiamine Elliot credits much of his knowledge of oxalates to Susan Owens, who's website can be found here: http://lowoxalate.info/ 54:40 Brian's story with oxalates 59:10 signs and symptoms of oxalates issues 1:10:00 Why Elliot chose thiamine and oxalates 1:17:00 Thiamine and the diet 1:30:00 How to find Elliot Instagram- https://instagram.com/eonutrition?igshid=YmMyMTA2M2Y= Twitter- Elliot Overton (@EO_Nutrition) / Twitter https://twitter.com/eo_nutrition?lang=en YouTube - https://youtube.com/@EONutrition Website- https://www.eonutrition.co.uk/ BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

18 Jan 20231h 41min

Part 180 - Mike Mutzel Gives a Masterclass on Reading Labs & Bloodwork

Mike earned his B.S. in Biology from Western Washington University in 2006 and completed his M.S. in Clinical Nutrition from the University of Bridgeport in 2015 and is a graduate of the Institute for Functional Medicine's (IFM) Applying Functional Medicine in Clinical Practice (AFMCP). https://highintensityhealth.com/about/ BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: 00:00- Head over to https://nosetotail.org/ for our nose to tail products Go to http://drinklmnt.com/peakhuman for a free gift from LMNT electrolytes. Join the sapien newsletter https://www.sapien.org/ 04:00- It will be much better to watch the video presentation on the Food Lies YouTube 06:24- The importance of exercise 12:40- Carb cycling and timing 15:20- Effects of blood viscosity 26:38- LDL cholesterol 35:00- How to assess the liver 39:13- Benefits of cholesterol 40:56- Triglycerides and a case study 47:10- Omega 3 and 6 49:30- Vitamin D 55:30- Mike's approach to looking at labs. Case studies 1:04:20- Post menopause 1:06:23- DHEA 1:09:05- Common male bloodwork For full show notes with links to all the studies join the Patreon BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

29 Dec 20221h 13min

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